Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain
Petermann-Rocha F, Valera-Gran D, Fernández-Pires P, Martens DS, Júlvez J, Rodríguez-Dehli C, Andiarena A, Lozano M, Fernández-Somoano A, Lertxundi A, Llop S, Guxens M, Nawrot TS, Navarrete-Muñoz EM. Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain. Pediatr Res. 2023 Apr;93(5):1419-1424. PMID: 35974160
Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort
Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C. Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort. Environ Pollut. 2023 Jan 1;316(Pt 2):120571. PMID: 36356884
Associations of residential greenspace exposure and fetal growth across four areas in Spain
Torres Toda M, Estarlich M, Ballester F, De Castro M, Fernández-Somoano A, Ibarluzea J, Iñiguez C, Lertxundi A, Subiza-Perez M, Sunyer J, Tardón A, Foraster M, Dadvand P. Associations of residential greenspace exposure and fetal growth across four areas in Spain. Health Place. 2022 Nov;78:102912. PMID: 36182749
Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study
Díaz-López A, Canals-Sans J, Julvez J, Fernandez-Barrés S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V. Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study. Sci Rep. 2022 Dec 1;12(1):20762. PMID: 36456588.
Author Correction: Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study. Sci Rep. 2023 Jan 18;13(1):993. PMID: 36653394
Arsenic exposure and respiratory outcomes during childhood in the INMA study
Signes-Pastor AJ, Díaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, García-Villarino M, Fernández-Somoano A, Julvez J, Carrasco P, Lertxundi A, Santa Marina L, Casas M, Meharg AA, Karagas MR, Vioque-Lopez J. Arsenic exposure and respiratory outcomes during childhood in the INMA study. PLoS One. 2022 Sep 9;17(9):e0274215. PMID: 36083997
Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7-9 Years of Age in the INMA Cohort Study
Compañ-Gabucio LM, Torres-Collado L, Garcia-de la Hera M, Fernández-Somoano A, Tardón A, Julvez J, Sunyer J, Rebagliato M, Murcia M, Ibarluzea J, Santa-Marina L, Vioque J. Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7-9 Years of Age in the INMA Cohort Study. Int J Environ Res Public Health. 2022 Sep 25;19(19):12123. PMID: 36231425
Environmental Noise Exposure and Sleep Habits among Children in a Cohort from Northern Spain
Arregi A, Lertxundi A, Vegas O, García-Baquero G, Ibarluzea J, Anabitarte A, Barroeta Z, Jimeno-Romero A, Subiza-Pérez M, Lertxundi N. Environmental Noise Exposure and Sleep Habits among Children in a Cohort from Northern Spain. Int J Environ Res Public Health. 2022 Dec 6;19(23):16321. PMID: 36498392
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
Fernandez-Jimenez N, Fore R, Cilleros-Portet A, Lepeule J, Perron P, Kvist T, Tian FY, Lesseur C, Binder AM, Lozano M, Martorell-Marugán J, Loke YJ, Bakulski KM, Zhu Y, Forhan A, Sammallahti S, Everson TM, Chen J, Michels KB, Belmonte T, Carmona-Sáez P, Halliday J, Daniele Fallin M, LaSalle JM, Tost J, Czamara D, Fernández MF, Gómez-Martín A, Craig JM, Gonzalez-Alzaga B, Schmidt RJ, Dou JF, Muggli E, Lacasaña M, Vrijheid M, Marsit CJ, Karagas MR, Räikkönen K, Bouchard L, Heude B, Santa-Marina L, Bustamante M, Hivert MF, Bilbao JR. A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health. Commun Biol. 2022 Nov 30;5(1):1313. PMID: 36446949
Exposure to natural environments during pregnancy and birth outcomes in 11 European birth cohorts
Torres Toda M, Avraam D, James Cadman T, Fossati S, de Castro M, Dedele A, Donovan G, Elhakeem A, Estarlich M, Fernandes A, Gonçalves R, Grazuleviciene R, Harris JR, Harskamp-van Ginkel MW, Heude B, Ibarluzea J, Iñiguez C, Wv Jaddoe V, Lawlor D, Lertxundi A, Lepeule J, McEachan R, Moirano G, Lt Nader J, Nybo Andersen AM, Pedersen M, Pizzi C, Roumeliotaki T, Santos S, Sunyer J, Yang T, Vafeiadi M, Gm Vrijkotte T, Nieuwenhuijsen M, Vrijheid M, Foraster M, Dadvand P. Exposure to natural environments during pregnancy and birth outcomes in 11 European birth cohorts. Environ Int. 2022 Dec;170:107648. PMID: 36436464
The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study
Puig-Vallverdú J, Romaguera D, Fernández-Barrés S, Gignac F, Ibarluzea J, Santa-Maria L, Llop S, Gonzalez S, Vioque J, Riaño-Galán I, Fernández-Tardón G, Pinar A, Turner MC, Arija V, Salas-Savadó J, Vrijheid M, Julvez J. The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study. Clin Nutr. 2022 Oct;41(10):2275-2283. PMID: 36087519
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