Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Maternal nut and fish consumption during pregnancy and child risky decision-making at 11 years old
Rivera MR, Pinar-Martí A, Babarro I, Ibarluzea J, Vioque J, Llop S, Fernández-Somoano A, Tardón A, Pascual-Rubio V, Fabregat-Sanjuan A, Fernández-Barrés S, Romaguera D, Guxens M, Julvez J. Maternal nut and fish consumption during pregnancy and child risky decision-making at 11 years old. Eur Child Adolesc Psychiatry. 2025 Nov;34(11):3643-3654. PMID: 40493090. Comment: Eur Child Adolesc Psychiatry. 2026 Jan;35(1):295-296. PMID: 40928651. Response: Eur Child Adolesc Psychiatry. 2026 Jan;35(1):301-302. PMID: 41042371
Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
Campos-Sánchez I, Navarrete-Muñoz EM, Barber-Valles JX, Martens DS, Riaño-Galán I, Irizar A, Llop S, Guxens M, Rodríguez-Dehli C, Babarro I, Lozano M, Vrijheid M, Nawrot T, Valera-Gran D. Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study. Children (Basel). 2025 Jul 2;12(7):875. PMID: 40723068
Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children
Whitworth KW, Lertxundi A, Yuan M, Rector-Houze A, Chen WJ, Guxens M, Julvez J, Swartz M, Symanski E, Valentin A, Iniguez C, González-Safont LL, Ibarluzea J. Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children. Environ Epidemiol. 2025 May 14;9(3):e396. PMID: 40375972
Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study
Pinar-Martí A, Ayala-Aldana N, Ruiz-Rivera M, Lertxundi N, Subiza-Pérez M, González-Safont L, Vioque J, Riaño-Galán I, Rodríguez-Dehli C, Iglesias-Vázquez L, Arija V, Fernández-Barrés S, Romaguera D, Pascual-Rubio V, Fabregat-Sanjuan A, Healy D, Basagaña X, Vrijheid M, Guxens M, Foraster M, Julvez J. Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study. Am J Clin Nutr. 2025 Jul;122(1):274-284. PMID: 40334748.
Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative
Valencia-Hernández CA, Yu Z, Gehring U, Koppelman GH, Standl M, Flexeder C, Schikowski T, Kress S, Melén E, Gruzieva O, Lõhmus M, Faner R, Agusti A, Wedzicha JA, Garcia-Aymerich J, Koch S, Nieuwenhuijsen M, Lertxundi A, Esplugues A, Ballester F, Arregi A, Markevych I, Bloom CI, Fuertes E; CADSET Clinical Research Collaboration. Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative. Environ Int. 2025 May;199:109493. PMID: 40311232
Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts
Warkentin S, Fossati S, Marquez S, Andersen AN, Andrusaityte S, Avraam D, Ballester F, Cadman T, Casas M, de Castro M, Chatzi L, Elhakeem A, d’Errico A, Guxens M, Grazuleviciene R, Harris JR, Hernandez CI, Heude B, Isaevska E, Jaddoe VWV, Karachaliou M, Lertxundi A, Lepeule J, McEachan RRC, Thorbjørnsrud Nader JL, Pedersen M, Santos S, Slofstra M, Stephanou EG, Swertz MA, Vrijkotte T, Yang TC, Nieuwenhuijsen M, Vrijheid M. Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts. Environ Int. 2025 Jun;200:109527. PMID: 40378473
Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology
Mulder TA, Guxens M, Rebagliato ML, Dineva M, Bath SC, Hunziker S, Sunyer J, Delgado-Saborit JM, Irizar Loibide A, Lertxundi N, Muetzel RL, Tiemeier H, Peeters RP, Korevaar TIM. Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology. J Clin Endocrinol Metab. 2025 Jun 17;110(7):2007-2015. PMID: 39329345
General population-based lung function trajectories over the life course: an accelerated cohort study
Garcia-Aymerich J, de Las Heras M, Carsin AE, Accordini S, Agustí A, Bui D, Dharmage SC, Dodd JW, Eze I, Gehring U, Gislason T, Granell R, Imboden M, Íñiguez C, Jeong A, Koch S, Koppelman GH, Leynaert B, Melén E, Perret J, Probst-Hensch N, Santa-Marina L, Torrent M, Vicendese D, Vonk JM, de Vries M, Walters EH, Wang G, Wedzicha JA, Jarvis D, Faner R. General population-based lung function trajectories over the life course: an accelerated cohort study. Lancet Respir Med. 2025 Jul;13(7):611-622. PMID: 40383131
Exposure to different types of residential greenness during pregnancy and early childhood and attention-deficit/hyperactivity disorder diagnosis: A nested case-control study
Luque-García L, García-Baquero G, Lertxundi A, Al-Delaimy WK, Yang TC, Delgado-Saborit JM, Guxens M, McEachan RRC, Vrijheid M, Estarlich M, Nieuwenhuijsen M, Ibarluzea J. Exposure to different types of residential greenness during pregnancy and early childhood and attention-deficit/hyperactivity disorder diagnosis: A nested case-control study. Sci Total Environ. 2025 Mar 15;969:178907. PMID: 39999706
Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference
Luque-García L, García-Baquero G, Lertxundi A, Al-Delaimy WK, Julvez J, Estarlich M, De Castro M, Guxens M, Lozano M, Subiza-Pérez M, Ibarluzea J. Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference. Int J Hyg Environ Health. 2025 Jan;263:114475. PMID: 39366079
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