Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

266 Results

Neurodevelopment -
Social inequalities -


Poverty, social exclusion, and mental health: the role of the family context in children aged 7-11 years INMA mother-and-child cohort study

González L, Estarlich M, Murcia M, Barreto-Zarza F, Santa-Marina L, Simó S, Larrañaga MI, Ruiz-Palomino E, Ibarluzea J, Rebagliato M. Poverty, social exclusion, and mental health: the role of the family context in children aged 7-11 years INMA mother-and-child cohort study. Eur Child Adolesc Psychiatry. 2022-2021 Jul 26. Online ahead of print. PMID: 34312704


Air pollution -
Intrauterine growth -


Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

Whitworth KW, Rector A, Ish J, Chauhan SPJ, Ibarluzea J, Guxens M, Swartz MD, Symanski E, Iñiguez C. Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort. Epidemiology. 2022 May 1;33(3):318-324. PMID: 35213509


No persistent organic compounds -
Respiratory health and atopy -


In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts

Abellan A, Mensink-Bout SM, Garcia-Esteban R, Beneito A, Chatzi L, Duarte-Salles T, Fernandez MF, Garcia-Aymerich J, Granum B, Iñiguez C, Jaddoe VWV, Kannan K, Lertxundi A, Lopez-Espinosa MJ, Philippat C, Sakhi AK, Santos S, Siroux V, Sunyer J, Trasande L, Vafeiadi M, Vela-Soria F, Yang TC, Zabaleta C, Vrijheid M, Duijts L, Casas M. In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts. Environ Int. 2022 Apr;162:107178. doi: 10.1016/j.envint.2022.107178. Epub 2022 Mar 18. PMID: 35314078.


Breastfeeding -
Persistent organic compounds -
Reproductive health -


Influence of gestational weight gain on the organochlorine pollution content of breast milk

Grimalt JO, Garí M, Santa-Marina L, Ibarluzea J, Sunyer J. Influence of gestational weight gain on the organochlorine pollution content of breast milk. Environ Res. 2022 Jun;209:112783. PMID: 35074353


Occupational health -
Reproductive health -


Maternal occupational exposures and fetal growth in a Spanish birth cohort

Ish J, Gimeno Ruiz de Porras D, Symanski E, Ballester F, Casas M, Delclos GL, Guxens M, Ibarluzea J, Iñiguez C, Santa-Marina L, Swartz MD, Whitworth KW. Maternal occupational exposures and fetal growth in a Spanish birth cohort. PLoS One. 2022 Apr 7;17(4):e0264530. PMID: 35390005


Neurodevelopment -
Nutrition -


Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain

Tahaei H, Gignac F, Pinar A, Fernandez-Barrés S, Romaguera D, Vioque J, Santa-Marina L, Subiza-Pérez M, Llop S, Soler-Blasco R, Arija V, Salas-Salvadó J, Tardón A, Riaño-Galán I, Sunyer J, Guxens M, Julvez J. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain. Nutrients. 2022 Jan 25;14(3):518. doi: 10.3390/nu14030518. PMID: 35276877


Metals -
Neurodevelopment -
Nutrition -


Prenatal arsenic exposure, arsenic methylation efficiency, and neuropsychological development among preschool children in a Spanish birth cohort

Soler-Blasco R, Murcia M, Lozano M, Sarzo B, Esplugues A, Riutort-Mayol G, Vioque J, Lertxundi N, Santa Marina L, Lertxundi A, Irizar A, Braeuer S, Ballester F, Llop S. Prenatal arsenic exposure, arsenic methylation efficiency, and neuropsychological development among preschool children in a Spanish birth cohort. Environ Res. 2022 May 1;207:112208. PMID: 34662579


Metals -
Neurodevelopment -


Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children

Ibarluzea J, Gallastegi M, Santa-Marina L, Jiménez Zabala A, Arranz E, Molinuevo A, Lopez-Espinosa MJ, Ballester F, Villanueva CM, Riano I, Sunyer J, Tardon A, Lertxundi A. Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children. Environ Res. 2022 May 1;207:112181. PMID: 34627799


Electromagnetics field -
Sleep problems -


Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents

Cabré-Riera A, van Wel L, Liorni I, Koopman-Verhoeff ME, Imaz L, Ibarluzea J, Huss A, Wiart J, Vermeulen R, Joseph W, Capstick M, Vrijheid M, Cardis E, Röösli M, Eeftens M, Thielens A, Tiemeier H, Guxens M. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents. Environ Res. 2022 Mar;204(Pt C):112291. PMID: 34757029


Metals -
Nutrition -
Tobacco -


Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

Lozano M, Murcia M, Soler-Blasco R, Casas M, Zubero B, Riutort-Mayol G, Gil F, Olmedo P, Grimalt JO, Amorós R, Lertxundi A, Vrijheid M, Ballester F, Llop S. Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors. Chemosphere. 2022 Jan;286(Pt 2):131809. PMID: 34388877


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