Resultats de l’estudi
Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood
Ruiz-Arenas C, Hernandez-Ferrer C, Vives-Usano M, Marí S, Quintela I, Mason D, Cadiou S, Casas M, Andrusaityte S, Gutzkow KB, Vafeiadi M, Wright J, Lepeule J, Grazuleviciene R, Chatzi L, Carracedo Á, Estivill X, Marti E, Escaramís G, Vrijheid M, González JR, Bustamante M. Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood. Elife. 2022 Mar 18;11:e65310. PMID: 35302492
Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lahti J, DeMeo DL, Zhang H, Karmaus W, Kull I, Koletzko B, Feinberg JI, Gagliardi L, Bouchard L, Ramlau-Hansen CH, Tiemeier H, Santorelli G, Maguire RL, Czamara D, Litonjua AA, Langhendries JP, Plusquin M, Lepeule J, Binder EB, Verduci E, Dwyer T, Carracedo Á, Ferre N, Eskenazi B, Kogevinas M, Nawrot TS, Munthe-Kaas MC, Herceg Z, Relton C, Melén E, Gruszfeld D, Breton C, Fallin MD, Ghantous A, Nystad W, Heude B, Snieder H, Hivert MF, Felix JF, Sørensen TIA, Bustamante M, Murphy SK, Raikkönen K, Oken E, Holloway JW, Arshad SH, London SJ, Holland N. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutat Res Rev Mutat Res. 2022 Jan-Jun;789:108415. PMID: 35690418
Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain)
Junqué E, Tardón A, Fernandez-Somoano A, Grimalt JO. Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain). Environ Res. 2022 Jul 15:113862. doi: 10.1016/j.envres.2022.113862. Epub ahead of print. PMID: 35850295
Serum concentrations of persistent organic pollutants mixture during pregnancy and anogenital distance in 8-year-old children from the INMA-Asturias cohort
García-Villarino M, Signes-Pastor AJ, Riaño-Galán I, Rodríguez-Dehli AC, Vizcaíno E, Grimalt JO, Fernández-Somoano A, Tardón A. Serum concentrations of persistent organic pollutants mixture during pregnancy and anogenital distance in 8-year-old children from the INMA-Asturias cohort. Environ Res. 2022 Jun 9;213:113607. doi: 10.1016/j.envres.2022.113607. Epub ahead of print. PMID: 35690090
Do prepubertal hormones, 2D:4D index and psychosocial context jointly explain 11-year-old preadolescents’ involvement in bullying?
Babarro I, Andiarena A, Fano E, García-Baquero G, Lebeña A, Arranz-Freijo EB, Ibarluzea J. Do prepubertal hormones, 2D:4D index and psychosocial context jointly explain 11-year-old preadolescents’ involvement in bullying? Biol Psychol. 2022 Jul;172:108379. PMID: 35690279
Pre and postnatal exposure to mercury and sexual development in 9-year-old children in Spain: The role of brain-derived neurotrophic factor
Sarzo B, Ballester F, Soler-Blasco R, Lopez-Espinosa MJ, Lozano M, Iriarte G, Beneito A, Riutort-Mayol G, Murcia M, Llop S. Pre and postnatal exposure to mercury and sexual development in 9-year-old children in Spain: The role of brain-derived neurotrophic factor. Environ Res. 2022 Jun 10;213:113620. doi: 10.1016/j.envres.2022.113620. Epub ahead of print. PMID: 35697081
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
Jami ES, Hammerschlag AR, Ip HF, Allegrini AG, Benyamin B, Border R, Diemer EW, Jiang C, Karhunen V, Lu Y, Lu Q, Mallard TT, Mishra PP, Nolte IM, Palviainen T, Peterson RE, Sallis HM, Shabalin AA, Tate AE, Thiering E, Vilor-Tejedor N, Wang C, Zhou A, Adkins DE, Alemany S, Ask H, Chen Q, Corley RP, Ehli EA, Evans LM, Havdahl A, Hagenbeek FA, Hakulinen C, Henders AK, Hottenga JJ, Korhonen T, Mamun A, Marrington S, Neumann A, Rimfeld K, Rivadeneira F, Silberg JL, van Beijsterveldt CE, Vuoksimaa E, Whipp AM, Tong X, Andreassen OA, Boomsma DI, Brown SA, Burt SA, Copeland W, Dick DM, Harden KP, Harris KM, Hartman CA, Heinrich J, Hewitt JK, Hopfer C, Hypponen E, Jarvelin MR, Kaprio J, Keltikangas-Järvinen L, Klump KL, Krauter K, Kuja-Halkola R, Larsson H, Lehtimäki T, Lichtenstein P, Lundström S, Maes HH, Magnus P, Munafò MR, Najman JM, Njølstad PR, Oldehinkel AJ, Pennell CE, Plomin R, Reichborn-Kjennerud T, Reynolds C, Rose RJ, Smolen A, Snieder H, Stallings M, Standl M, Sunyer J, Tiemeier H, Wadsworth SJ, Wall TL, Whitehouse AJO, Williams GM, Ystrøm E, Nivard MG, Bartels M, Middeldorp CM. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):934-945. PMID: 35378236
Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation
Küpers LK, Fernández-Barrés S, Mancano G, Johnson L, Ott R, Vioque J, Colombo M, Landgraf K, Tobi EW, Körner A, Gaillard R, de Vries JHM, Jaddoe VWV, Vrijheid M, Sharp GC, Felix JF. Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation. Diabetes Care. 2022 Aug 1;45(8):1822-1832. PMID: 35708509
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Vogelezang S, Bradfield JP; Early Growth Genetics Consortium, Grant SFA, Felix JF, Jaddoe VWV. Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Med Genomics. 2022 Jun 4;15(1):124. PMID: 35659227
The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
Carreras-Gallo N, Cáceres A, Balagué-Dobón L, Ruiz-Arenas C, Andrusaityte S, Carracedo Á, Casas M, Chatzi L, Grazuleviciene R, Gutzkow KB, Lepeule J, Maitre L, Nieuwenhuijsen M, Slama R, Stratakis N, Thomsen C, Urquiza J, Wright J, Yang T, Escaramís G, Bustamante M, Vrijheid M, Pérez-Jurado LA, González JR. The early-life exposome modulates the effect of polymorphic inversions on DNA methylation. Commun Biol. 2022 May 12;5(1):455. PMID: 35550596
Urban environment and health behaviours in children from six European countries
Fernández-Barrés S, Robinson O, Fossati S, Márquez S, Basagaña X, de Bont J, de Castro M, Donaire-Gonzalez D, Maitre L, Nieuwenhuijsen M, Romaguera D, Urquiza J, Chatzi L, Iakovides M, Vafeiadi M, Grazuleviciene R, Dedele A, Andrusaityte S, Marit Aasvang G, Evandt J, Hjertager Krog N, Lepeule J, Heude B, Wright J, McEachan RRC, Sassi F, Vineis P, Vrijheid M. Urban environment and health behaviours in children from six European countries. Environ Int. 2022 Jul;165:107319. PMID: 35667344
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Sammallahti S, Koopman-Verhoeff ME, Binter AC, Mulder RH, Cabré-Riera A, Kvist T, Malmberg ALK, Pesce G, Plancoulaine S, Heiss JA, Rifas-Shiman SL, Röder SW, Starling AP, Wilson R, Guerlich K, Haftorn KL, Page CM, Luik AI, Tiemeier H, Felix JF, Raikkonen K, Lahti J, Relton CL, Sharp GC, Waldenberger M, Grote V, Heude B, Annesi-Maesano I, Hivert MF, Zenclussen AC, Herberth G, Dabelea D, Grazuleviciene R, Vafeiadi M, Håberg SE, London SJ, Guxens M, Richmond RC, Cecil CAM. Longitudinal associations of DNA methylation and sleep in children: a meta-analysis. Clin Epigenetics. 2022 Jul 5;14(1):83. PMID: 35790973
Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood
Fuentes-Paez G, Escaramís G, Aguilar-Lacasaña S, Andrusaityte S, Brantsæter AL, Casas M, Charles MA, Chatzi L, Lepeule J, Grazuleviciene R, Gützkow KB, Heude B, Maitre L, Ruiz-Arenas C, Sunyer J, Urquiza J, Yang TC, Wright J, Vrijheid M, Vilor-Tejedor N, Bustamante M. Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood. Front Genet. 2022 May 12;13:867611. PMID: 35646076
Maternal occupational exposure to chemicals and child cognitive function
Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD, Whitworth KW. Maternal occupational exposure to chemicals and child cognitive function. Pediatr Res. 2022 May 16. doi: 10.1038/s41390-022-02089-6. Epub ahead of print. PMID: 35578010
Does exposure to greenness improve children’s neuropsychological development and mental health? A Navigation Guide systematic review of observational evidence for associations
Luque-García L, Corrales A, Lertxundi A, Díaz S, Ibarluzea J. Does exposure to greenness improve children’s neuropsychological development and mental health? A Navigation Guide systematic review of observational evidence for associations. Environ Res. 2022 Apr 15;206:112599. PMID: 34932982
Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls
Freire C, Castiello F, Lopez-Espinosa MJ, Beneito A, Lertxundi A, Jimeno-Romero A, Vrijheid M, Casas M. Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls. Environ Res. 2022 Jun 15:113606. doi: 10.1016/j.envres.2022.113606. Epub ahead of print. PMID: 35716812
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022 Apr;10(4):243-252. PMID: 35255260
Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, Johnson L, Bustamante M, Jaddoe VWV, Hivert MF, Starling AP, de Vries JHM, Sharp GC, Vrijheid M, Felix JF. Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics. 2022 Mar 2:1-13. Epub ahead of print. PMID: 35236238
Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children
de Prado-Bert P, Warembourg C, Dedele A, Heude B, Borràs E, Sabidó E, Aasvang GM, Lepeule J, Wright J, Urquiza J, Gützkow KB, Maitre L, Chatzi L, Casas M, Vafeiadi M, Nieuwenhuijsen MJ, de Castro M, Grazuleviciene R, McEachan RRC, Basagaña X, Vrijheid M, Sunyer J, Bustamante M. Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children. Environ Res. 2022 Aug;211:113109. PMID: 35292243
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hivert MF, Oken E, Sunyer J, Cecil CAM, Sharp G. Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Mol Psychiatry. 2022 Apr;27(4):2126-2135. PMID: 35145228
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