Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study
Petermann-Rocha F, Valera-Gran D, Prieto-Botella D, Martens DS, Gonzalez-Palacios S, Riaño-Galán I, Murcia M, Irizar A, Julvez J, Santa-Marina L, Tardón A, Sunyer J, Vioque J, Nawrot T, Navarrete-Muñoz EM. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study. Nutrients. 2023 Oct 9;15(19):4303. PMID: 37836587
Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index
Descarpentrie A, Calas L, Cornet M, Heude B, Charles MA, Avraam D, Brescianini S, Cadman T, Elhakeem A, Fernández-Barrés S, Harris JR, Inskip H, Julvez J, Llop S, Margetaki K, Maritano S, Nader JLT, Roumeliotaki T, Salika T, Subiza-Pérez M, Vafeiadi M, Vrijheid M, Wright J, Yang T, Dargent-Molina P, Lioret S. Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index. Pediatr Obes. 2023 Dec;18(12):e13079. PMID: 37795656
Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children
Soler-Blasco R, Llop S, Riutort-Mayol G, Lozano M, Vallejo-Ortega J, Murcia M, Ballester F, Irizar A, Andiarena A, Fernandez-Jimenez N, Braeuer S, Harari F. Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children. Environ Sci Technol. 2023 Oct 17;57(41):15366-15378. PMID: 37787746
A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles
Kiewiet MBG, Lupinek C, Vrtala S, Wieser S, Baar A, Kiss R, Kull I, Melén E, Wickman M, Porta D, Gori D, Gehring U, Aalberse R, Sunyer J, Standl M, Heinrich J, Waiblinger D, Wright J, Antó JM, Bousquet J, van Hage M, Valenta R. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles. Allergy. 2023 Jul;78(7):2007-2018. PMID: 36815272
Creatine Kinase Is Decreased in Childhood Asthma
Guerra S, Ledford JG, Melén E, Lavi I, Carsin AE, Stern DA, Zhai J, Vidal M, Bustamante M, Addison KJ, Vallecillo RG, Billheimer D, Koppelman GH, Garcia-Aymerich J, Lemonnier N, Fitó M, Dobaño C, Kebede Merid S, Kull I, McEachan RRC, Wright J, Chatzi L, Kogevinas M, Porta D, Narduzzi S, Ballester F, Esplugues A, Zabaleta C, Irizar A, Sunyer J, Halonen M, Bousquet J, Martinez FD, Anto JM. Creatine Kinase Is Decreased in Childhood Asthma. Am J Respir Crit Care Med. 2023 Mar 1;207(5):544-552. PMID: 35876143
Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
Rouxel E, Costet N, Monfort C, Audouze K, Cirugeda L, Gaudreau E, Grimalt JO, Ibarluzea J, Lainé F, Llop S, Lopez-Espinosa MJ, Rouget F, Santa-Marina L, Vrijheid M, Chevrier C, Casas M, Warembourg C. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents. Environ Int. 2023 Aug;178:108056. PMID: 37379720
Sleep duration in preschool age and later behavioral and cognitive outcomes: an individual participant data meta-analysis in five European cohorts
Guerlich K, Avraam D, Cadman T, Calas L, Charles MA, Elhakeem A, Fernández-Barrés S, Guxens M, Heude B, Ibarluzea J, Inskip H, Julvez J, Lawlor DA, Murcia M, Salika T, Sunyer J, Tafflet M, Koletzko B, Grote V, Plancoulaine S. Sleep duration in preschool age and later behavioral and cognitive outcomes: an individual participant data meta-analysis in five European cohorts. Eur Child Adolesc Psychiatry. 2024 Jan;33(1):167-177. PMID: 36749392
Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study
Florian S, Ichou M, Panico L, Pinel-Jacquemin S, Vrijkotte TGM, Harskamp-van Ginkel MW, Huang RC, Carson J, Rodriguez LSM, Subiza-Pérez M, Vrijheid M, Fernández-Barrés S, Yang TC, Wright J, Corpeleijn E, Cardol M, Isaevska E, Moccia C, Kooijman MN, Voerman E, Jaddoe V, Welten M, Spada E, Rebagliato M, Beneito A, Ronfani L, Charles MA. Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study. BMJ Open. 2023 Mar 23;13(3):e060932. PMID: 36958776
Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study
Cano-Sancho G, Warembourg C, Güil N, Stratakis N, Lertxundi A, Irizar A, Llop S, Lopez-Espinosa MJ, Basagaña X, González JR, Coumoul X, Fernández-Barrés S, Antignac JP, Vrijheid M, Casas M. Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study. Environ Health Perspect. 2023 Mar;131(3):37011. PMID: 36927187
PFAS levels and exposure determinants in sensitive population groups
Fábelová L, Beneito A, Casas M, Colles A, Dalsager L, Den Hond E, Dereumeaux C, Ferguson K, Gilles L, Govarts E, Irizar A, Lopez Espinosa MJ, Montazeri P, Morrens B, Patayová H, Rausová K, Richterová D, Rodriguez Martin L, Santa-Marina L, Schettgen T, Schoeters G, Haug LS, Uhl M, Villanger GD, Vrijheid M, Zaros C, Palkovičová Murínová Ľ. PFAS levels and exposure determinants in sensitive population groups. Chemosphere. 2023 Feb;313:137530. PMID: 36509187
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