Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities
Guxens M, Botella N, Stafoggia M, Canto M, Petricola S, Valentín A, Lertxundi A, Fernández-Somoano A, Freire C, García-Altés A, Diez E, Marí-Dell’Olmo M, Iñiguez C, López MJ, Ramis R, Binter AC. Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities. Eur J Epidemiol. 2025 Sep;40(9):1105-1121. PMID: 40705228
Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals
Gonçalves R, Blaauwendraad S, Avraam D, Beneíto A, Charles MA, Elhakeem A, Escribano J, Etienne L, García-Baquero Moneo G, Soares AG, de Groot J, Grote V, Gruszfeld D, Guerlich K, Guxens M, Heude B, Koletzko B, Lertxundi A, Lozano M, El Marroun H, McEachan R, Pinot de Moira A, Santorelli G, Strandberg-Larsen K, Tafflet M, Vainqueur C, Verduci E, Vrijheid M, Welten M, Wright J, Yang TC, Gaillard R, Jaddoe VWV. Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals. Lancet Reg Health Eur. 2025 Feb 26;52:101247. PMID: 40094119
Windows of susceptibility of prenatal and childhood exposure to air pollution and lung function at 6-8 years in the Spanish INMA (INfancia y Medio Ambiente) birth cohort
Domínguez A, Rivas I, Koch S, Binter AC, Iñiguez C, Estarlich M, Ferrero A, Lertxundi A, Zabaleta C, Nieuwenhuijsen M, Garcia-Aymerich J, Sunyer J, Vrijheid M, Guxens M, Casas M, Basagaña X. Windows of susceptibility of prenatal and childhood exposure to air pollution and lung function at 6-8 years in the Spanish INMA (INfancia y Medio Ambiente) birth cohort. Environ Res. 2025 Nov 15;285(Pt 4):122585. PMID: 40816673
Impact of pet ownership in early childhood at ages 1 and 4-5 years on mental health at ages 7-8: findings from the INMA project
González L, Guxens M, Sarzo B, Andiarena A, Santa-Marina L, Tardón A, Julvez J, Rodríguez-Dehli C, Rebagliato M, Estarlich M. Impact of pet ownership in early childhood at ages 1 and 4-5 years on mental health at ages 7-8: findings from the INMA project. World J Pediatr. 2025 Oct;21(10):1003-1016. PMID: 41045339
Investigating the relationship between neighbourhood characteristics, perceived social support and psychological wellbeing in Spanish adolescents
Piera Pi-Sunyer B, Bignardi G, García-Baquero G, Dadvand P, Vrijheid M, Guxens M, Esplugues A, Delgado-Saborit JM, Ibarluzea J, Blakemore SJ, Subiza-Pérez M. Investigating the relationship between neighbourhood characteristics, perceived social support and psychological wellbeing in Spanish adolescents. Sci Rep. 2025 Nov 6;15(1):38845. PMID: 41198832
Association between early-life exposure to mercury and cardiometabolic risk factors development in adolescence
Soler-Blasco R, Lozano M, Vallejo-Ortega J, Marina LS, Barroeta Z, Coscollá C, Iriarte G, Braeuer S, Ballester F, Llop S. Association between early-life exposure to mercury and cardiometabolic risk factors development in adolescence. Sci Total Environ. 2025 Dec 15;1008:180913. PMID: 41264948
Assessing metal mixture effects on neuropsychological development: A trade-off between complexity and interpretability
Diaz-Coto S, Notario-Barandiaran L, Martinez-Camblor P, Lozano M, Llop S, Tardón A, Rodríguez-Dehli C, Irizar A, Lertxundi N, Guxens M, Julvez J, Signes-Pastor AJ. Assessing metal mixture effects on neuropsychological development: A trade-off between complexity and interpretability. Int J Hyg Environ Health. 2026 Jan;271:114697. PMID: 41124768.
Exposure to high temperature and sleep in preadolescents from two European birth cohorts
Essers E, Granés L, Botella N, Petricola S, González-Safont L, Arregi A, Vegas O, Vrijheid M, Iñiguez C, El Marroun H, Tiemeier H, Guxens M. Exposure to high temperature and sleep in preadolescents from two European birth cohorts. Environ Int. 2025 Jun;200:109543. PMID: 40424701
Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood
Brennan Kearns P, González L, Soler-Blasco R, Andiarena A, Santa-Marina L, Casas M, Burgaleta M, Vrijheid M, Guxens M. Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood. Environ Res. 2025 Nov 15;285(Pt 2):122380. PMID: 40692023
Seroepidemiology of maternal and childhood pathogen exposure in three European mother-child cohorts
Karachaliou M, Vidal M, Pembrey L, Bustamante M, Espinosa A, Mason D, Bañuls M, Casabonne D, Roumeliotaki T, Bempi V, Marin N, Delgado-Saborit JM, Loreto SMR, Ibarluzea J, Vrijheid M, Aguilar R, Dobaño C, Kogevinas M. Seroepidemiology of maternal and childhood pathogen exposure in three European mother-child cohorts. Int J Infect Dis. 2025 Oct;159:107994. PMID: 40701399
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