Gipuzkoa

Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.

L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.

Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.

  • Finançadors de la cohort INMA-Gipuzkoa:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Entitats Col·laboradores:

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340 Resultats

Creixement postnatal i Obesitat -


Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024 Mar 16;403(10431):1027-1050. PMID: 38432237


Factors familiars -
Neurodesenvolupament -


Early childcare arrangements and children’s internalizing and externalizing symptoms: an individual participant data meta-analysis of six prospective birth cohorts in Europe

Barry KM, Avraam D, Cadman T, Elhakeem A, El Marroun H, Jansen PW, Nybo-Andersen AM, Strandberg-Larsen K, Safont LG, Soler-Blasco R, Barreto-Zarza F, Julvez J, Vrijheid M, Heude B, Charles MA, Gomajee AR, Melchior M. Early childcare arrangements and children’s internalizing and externalizing symptoms: an individual participant data meta-analysis of six prospective birth cohorts in Europe. Lancet Reg Health Eur. 2024 Aug 21;45:101036. PMID: 39262448


Desigualtats socials -
Exposoma -


Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies

Pizzi C, Moirano G, Moccia C, Maule M, D’Errico A, Vrijheid M, Cadman TJ, Fossati S, Nieuwenhuijsen M, Beneito A, Calas L, Duijts L, Elhakeem A, Harris JR, Heude B, Jaddoe V, Lawlor DA, Lioret S, McEachan RR, Nader JL, Pedersen M, Pinot de Moira A, Strandberg-Larsen K, Subiza-Pérez M, Vafeiadi M, Welten M, Wright J, Yang TC, Richiardi L. Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies. Soc Sci Med. 2024 Oct;359:117275. PMID: 39236481


Activitat física - sedentarisme -
Contaminació de l'aire -
Entorno urbano y Verdor -
Nutrició -
Problemes de la son -
Soroll -


Urban environment exposures, energy balance-related behaviors and their combination in preschoolers from three European countries

Descarpentrie A, Dargent-Molina P, Arregi A, Carrasco P, Estarlich M, Guxens M, McEachan R, Nieuwenhuijsen M, Subiza-Pérez M, Wright J, Charles MA, Heude B, Vrijheid M, Lioret S. Urban environment exposures, energy balance-related behaviors and their combination in preschoolers from three European countries. Environ Int. 2024 Aug;190:108880. PMID: 39024825


Alteracions hormonals -
Complicacions embaràs -
Salut reproductiva -


Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis

Derakhshan A, Männistö T, Chen L, Osinga JAJ, Ashoor G, Lu X, Bliddal S, Tao FB, Brown SJ, Vaidya B, Hattersley AT, Itoh S, Popova PV, Aminorroaya A, Kishi R, Kianpour M, Vasukova EA, López-Bermejo A, Oken E, Chatzi L, Vafeiadi M, Bramer WM, Bassols J, Lertxundi A, Fernández-Somoano A, Carrasco P, Auvinen J, Huang K, Feldt-Rasmussen U, Grineva EN, Alexander EK, Pearce EN, Chaker L, Walsh JP, Peeters RP, Guxens M, Suvanto E, Nicolaides KH, Korevaar TIM. Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis. J Clin Endocrinol Metab. 2024 Feb 20;109(3):e1290-e1298. PMID: 37878891


Desigualtats socials -
Estrès -
Factors familiars -


Hair cortisol determinants in 11-year-old children: Environmental, social and individual factors

Arregi A, Vegas O, Lertxundi A, García-Baquero G, Ibarluzea J, Andiarena A, Babarro I, Subiza-Pérez M, Lertxundi N. Hair cortisol determinants in 11-year-old children: Environmental, social and individual factors. Horm Behav. 2024 Aug;164:105575. PMID: 38851169


Metalls -
Nutrició -


Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA)

Oncina-Cánovas A, Vioque J, Riutort-Mayol G, Soler-Blasco R, Irizar A, Barroeta Z, Fernández-Somoano A, Tardón A, Vrijheid M, Guxens M, Carey M, Meharg C, Ralphs K, McCreanor C, Meharg A, Signes-Pastor AJ. Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA). Int J Hyg Environ Health. 2024 Apr;257:114344. PMID: 38430670


Alteracions hormonals -
Salut reproductiva -


Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis

Osinga JAJ, Liu Y, Männistö T, Vafeiadi M, Tao FB, Vaidya B, Vrijkotte TGM, Mosso L, Bassols J, López-Bermejo A, Boucai L, Aminorroaya A, Feldt-Rasmussen U, Hisada A, Yoshinaga J, Broeren MAC, Itoh S, Kishi R, Ashoor G, Chen L, Veltri F, Lu X, Taylor PN, Brown SJ, Chatzi L, Popova PV, Grineva EN, Ghafoor F, Pirzada A, Kianpour M, Oken E, Suvanto E, Hattersley A, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Delgado-Saborit JM, Fernández-Somoano A, Santa-Marina L, Boelaert K, Brenta G, Dhillon-Smith R, Dosiou C, Eaton JL, Guan H, Lee SY, Maraka S, Morris-Wiseman LF, Nguyen CT, Shan Z, Guxens M, Pop VJM, Walsh JP, Nicolaides KH, D’Alton ME, Visser WE, Carty DM, Delles C, Nelson SM, Alexander EK, Chaker L, Palomaki GE, Peeters RP, Bliddal S, Huang K, Poppe KG, Pearce EN, Derakhshan A, Korevaar TIM. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis. Thyroid. 2024 May;34(5):646-658. PMID: 38546971


Contaminació de l'aire -
Neurodesenvolupament -


Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood

Crooijmans KLHA, Iñiguez C, Withworth KW, Estarlich M, Lertxundi A, Fernández-Somoano A, Tardón A, Ibarluzea J, Sunyer J, Guxens M, Binter AC. Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood. Environ Int. 2024 Apr;186:108604. PMID: 38564945


Epigenètica -
Neurodesenvolupament -


Evaluating the association between placenta DNA methylation and cognitive functions in the offspring

Diez-Ahijado L, Cilleros-Portet A, Fernández-Jimenez N, Fernández MF, Guxens M, Julvez J, Llop S, Lopez-Espinosa MJ, Subiza-Pérez M, Lozano M, Ibarluzea J, Sunyer J, Bustamante M, Cosin-Tomas M. Evaluating the association between placenta DNA methylation and cognitive functions in the offspring. Transl Psychiatry. 2024 Sep 20;14(1):383. PMID: 39304652


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