Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems
Manuel Lozano, Karin Broberg, Raquel Soler-Blasco, Gabriel Riutort-Mayol, Ferran Ballester, Llúcia González, Mario Murcia, Joan O. Grimalt, Fernando Gil, Pablo Olmedo, Simone Braeuer, Maribel Casas, Mònica Guxens, Amaia Irizar, Nerea Lertxundi, Miren Begoña Zubero, Loreto Santa Marina & Sabrina Llop. Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems. Expo Health 16, 679–692 (2024). https://link.springer.com/article/10.1007/s12403-023-00585-6
Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence
Llop S, Lönnqvist J, Lopez-Espinosa MJ, Murcia M, Santa-Marina L, Ballester F, Irizar A, Braeuer S, Esplugues A, Lozano M, Vallejo-Ortega J, García-Baquero G, Barroeta Z, Harari F, Soler-Blasco R. Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence. Environ Res. 2026 Mar 15;293:123773. PMID: 41539525
Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity
Hernangomez-Laderas A, Cilleros-Portet A, Marí S, González-García BP, Arregi A, Jimeno-Romero A, Irizar A, García-Santisteban I, Lesseur C, Fernandez-Jimenez N, Bilbao JR. Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity. NPJ Genom Med. 2025 Jun 20;10(1):49. PMID: 40541940
Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort
San Román A, Abilleira E, González-Gaya B, Ayala-Cabrera JF, Barroeta Z, Etxebarria N, Irizar A. Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort. Environ Res. 2025 Oct 15;283:122198. PMID: 40543869.
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies
Standl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J, Herrera-Luis E, Holloway JW, Hottenga J, O’B Hourihane J, Hu C, Hveem K, Irizar A, Jacquemin B, Jessen L, Kress S, Kurukulaaratchy RJ, Lau S, Llop S, Løset M, Marenholz I, Mason D, McCartney DL, Melbye M, Melén E, Minica C, Murray CS, Nijsten T, Pardo LM, Pasmans S, Pennell CE, Rinnov MR, Santorelli G, Schikowski T, Sheehan D, Simpson A, Söderhäll C, Thomas LF, Thyssen JP, Torrent M, van Beijsterveldt T, Visconti A, Vonk JM, Wang CA, Xu CJ, Ziyab AH; UK Translational Research Network in Dermatology; BIOMAP Consortium; Custovic A, Di Meglio P, Duijts L, Flohr C, Irvine AD, Koppelman GH, Lee YA, Reynolds NJ, Smith C, Langan SM, Paternoster L, Brown SJ. Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies. Allergy. 2025 Aug;80(8):2201-2212. PMID: 40462597. Erratum in: Allergy. 2026 Feb;81(2):626. PMID: 40958161 .
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
Osinga JAJ, Derakhshan A, Karachaliou M, Poppe KG, Warringa L, Verdonk K, Vaidya B, Männistö T, López-Bermejo A, Bassols J, Broeren MAC, Brown SJ, Jensen RC, Popova PV, Pop VJM, Feldt-Rasmussen U, Aminorroaya A, Bliddal S, Mosso L, Chatzi L, Boucai L, Itoh S, Kishi R, Kleynen P, Ashoor G, Oken E, Grineva EN, Lu X, Lertxundi A, Murcia M, Meertens-Gunput STG, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Fernández-Somoano A, Suvanto E, Guxens M, Daraki V, Mathieu C, Kianpour M, Glintborg D, Jensen TK, Alexander E, Chaker L, Malone F, Messerlian G, Hattersley A, Harley KG, Pearce EN, Visser WE, Vrijkotte TGM, Peeters RP, Palomaki GE, Lowe W, Eskenazi B, Chen LM, Walsh JP, Nicolaides KH, Carty DM, Delles C, Tao FB, Huang K, Maraka S, D’Alton ME, Painter RC, Andersen MS, Benhalima K, Korevaar TIM. Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis. Lancet Diabetes Endocrinol. 2025 Aug;13(8):651-661. PMID: 40609565
Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts
Pinot de Moira A, Aurup AV, Avraam D, Zugna D, Jensen AKG, Welten M, Cadman T, de Lauzon-Guillain B, Duijts L, Elhakeem A, Esplugues A, Garcia-Aymerich J, García-Baquero G, González Safont L, Harris JR, Iñiguez C, Jaddoe VWV, McEachan RRC, Nader JLT, Santa Marina L, Swertz MA, Tafflet M, Vrijheid M, Wright J, Yang TC, Taylor-Robinson D, Richiardi L, Nybo Andersen AM. Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts. J Allergy Clin Immunol Pract. 2025 Jun;13(6):1385-1396. PMID: 40314625
Association of environmental noise exposure with cortisol levels in children from eight European birth cohorts
Arregi A, Robinson O, Aasvang GM, Andrusaityte S, Dedele A, Evandt J, Garcia-Baquero G, Krog NH, Guxens M, Jaddoe VWV, Karachaliou M, Lertxundi A, Margetaki K, McEachan R, Nieuwenhuijsen M, Philippat C, Pozo OJ, Slama R, Subiza-Pérez M, van Rossum EFC, Vrijheid M, Wright J, Yang TC, Vegas O, Lertxundi N. Association of environmental noise exposure with cortisol levels in children from eight European birth cohorts. Environ Res. 2025 Jul 15;277:121541. PMID: 40203977
Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities
Guxens M, Botella N, Stafoggia M, Canto M, Petricola S, Valentín A, Lertxundi A, Fernández-Somoano A, Freire C, García-Altés A, Diez E, Marí-Dell’Olmo M, Iñiguez C, López MJ, Ramis R, Binter AC. Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities. Eur J Epidemiol. 2025 Sep;40(9):1105-1121. PMID: 40705228
Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals
Gonçalves R, Blaauwendraad S, Avraam D, Beneíto A, Charles MA, Elhakeem A, Escribano J, Etienne L, García-Baquero Moneo G, Soares AG, de Groot J, Grote V, Gruszfeld D, Guerlich K, Guxens M, Heude B, Koletzko B, Lertxundi A, Lozano M, El Marroun H, McEachan R, Pinot de Moira A, Santorelli G, Strandberg-Larsen K, Tafflet M, Vainqueur C, Verduci E, Vrijheid M, Welten M, Wright J, Yang TC, Gaillard R, Jaddoe VWV. Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals. Lancet Reg Health Eur. 2025 Feb 26;52:101247. PMID: 40094119
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