Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
Rammah A, Whitworth KW, Amos CI, Estarlich M, Guxens M, Ibarluzea J, Iñiguez C, Subiza-Pérez M, Vrijheid M, Symanski E. Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort. Int J Environ Res Public Health. 2021 Sep 4;18(17):9354.PMID: 34501944
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
Everson TM, Vives-Usano M, Seyve E, Cardenas A, Lacasaña M, Craig JM, Lesseur C, Baker ER, Fernandez-Jimenez N, Heude B, Perron P, Gónzalez-Alzaga B, Halliday J, Deyssenroth MA, Karagas MR, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke YJ, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández MF, Tost J, Gómez-Martín A, London SJ, Sunyer J, Marsit CJ, Lepeule J, Hivert MF, Bustamante M. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. Nat Commun. 2021 Aug 24;12(1):5095. PMID: 34429407
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
Alemany S, Avella-García C, Liew Z, García-Esteban R, Inoue K, Cadman T, López-Vicente M, González L, Riaño Galán I, Andiarena A, Casas M, Margetaki K, Strandberg-Larsen K, Lawlor DA, El Marroun H, Tiemeier H, Iñiguez C, Tardón A, Santa-Marina L, Júlvez J, Porta D, Chatzi L, Sunyer J. Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts. Eur J Epidemiol. 2021 Oct;36(10):993-1004. PMID: 34046850
Urinary arsenic species and methylation efficiency during pregnancy: Concentrations and associated factors in Spanish pregnant women
Soler-Blasco R, Murcia M, Lozano M, Sarzo B, Esplugues A, Vioque J, Lertxundi N, Marina LS, Lertxundi A, Irizar A, Braeuer S, Goesler W, Ballester F, Llop S. Urinary arsenic species and methylation efficiency during pregnancy: Concentrations and associated factors in Spanish pregnant women. Environ Res. 2021 May;196:110889. PMID: 33607098
Prenatal manganese serum levels and neurodevelopment at 4 years of age
Irizar A, Molinuevo A, Andiarena A, Jimeno-Romero A, San Román A, Broberg K, Llop S, Soler-Blasco R, Murcia M, Ballester F, Lertxundi A. Prenatal manganese serum levels and neurodevelopment at 4 years of age. Environ Res. 2021 Jun;197:111172. PMID: 33857462
Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project
Carrizosa C, Murcia M, Ballesteros V, Costa O, Manzano-Salgado CB, Ibarluzea J, Iñiguez C, Casas M, Andiarena A, Llop S, Lertxundi A, Schettgen T, Sunyer J, Ballester F, Vrijheid M, Lopez-Espinosa MJ. Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project. J Hazard Mater. 2021 Aug 15;416:125185. PMID: 33882389
Association between prenatal exposure to air pollutants and newborn thyroxine (T4) levels
Irizar A, Txintxurreta A, Molinuevo A, Jimeno-Romero A, Anabitarte A, Álvarez JI, Martínez MD, Santa-Marina L, Ibarluzea J, Lertxundi A. Association between prenatal exposure to air pollutants and newborn thyroxine (T4) levels. Environ Res. 2021 Jun;197:111132. PMID: 33839121
Family Context Assessment in Middle Childhood: A Tool Supporting Social, Educational, and Public Health Interventions
Barreto-Zarza F, Sánchez de Miguel M, Ibarluzea J, González-Safont L, Rebagliato M, Arranz-Freijo EB. Family Context Assessment in Middle Childhood: A Tool Supporting Social, Educational, and Public Health Interventions. Int J Environ Res Public Health. 2021 Jan 26;18(3):1094.
PMID: 33530634
Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents
Birks LE, van Wel L, Liorni I, Pierotti L, Guxens M, Huss A, Foerster M, Capstick M, Eeftens M, El Marroun H, Estarlich M, Gallastegi M, Safont LG, Joseph W, Santa-Marina L, Thielens A, Torrent M, Vrijkotte T, Wiart J, Röösli M, Cardis E, Vermeulen R, Vrijheid M. Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents. Environ Res. 2021 Feb;193:110505. PMID: 33245886
Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents
Cabré-Riera A, van Wel L, Liorni I, Thielens A, Birks LE, Pierotti L, Joseph W, González-Safont L, Ibarluzea J, Ferrero A, Huss A, Wiart J, Santa-Marina L, Torrent M, Vrijkotte T, Capstick M, Vermeulen R, Vrijheid M, Cardis E, Röösli M, Guxens M. Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents. Int J Hyg Environ Health. 2021 Jan;231:113659. PMID: 33221634
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