Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Iodine Supplementation During Pregnancy and Infant Neuropsychological Development. INMA Mother and Child Cohort Study
Rebagliato M, Murcia M, Alvarez-Pedrerol M, Espada M, Fernández-Somoano A, Lertxundi N, Navarrete-Muñoz EM, Forns J, Aranbarri A, Llop S, Julvez J, Tardón A, Ballester F. Iodine Supplementation During Pregnancy and Infant Neuropsychological Development: INMA Mother and Child Cohort Study. Am J Epidemiol. 2013 May 1;177(9):944-53.PMID: 23548753
Prenatal exposure to cooking gas and respiratory health in infants is modified by tobacco smoke exposure and diet in the INMA birth cohort study
Esplugues A, Estarlich M, Sunyer J, Fuentes-Leonarte V, Basterrechea M, Vrijheid M, Riaño I, Santa-Marina L, Tardón A, Martinez D, Ballester F. Prenatal exposure to cooking gas and respiratory health in infants is modified by tobacco smoke exposure and diet in the INMA birth cohort study. Environ Health. 2013 Dec 1;12:100. PMID: 24289253
Maternal smoking during pregnancy and fetal biometry: the INMA Mother and Child Cohort Study
Iñiguez C, Ballester F, Costa O, Murcia M, Souto A, Santa-Marina L, Aurrekoetxea JJ, Espada M, Vrijheid M, Alvarez-Avellón SM, Alvarez-Pedrerol M, Rebagliato M; INMA Study Investigators. Maternal smoking during pregnancy and fetal biometry: the INMA Mother and Child Cohort Study. Am J Epidemiol. 2013 Oct 1;178(7):1067-75. PMID: 24008909
Prenatal and postnatal insecticide use and infant neuropsychological development in a multicenter birth cohort study
Llop S, Julvez J, Fernandez-Somoano A, Santa Marina L, Vizcaino E, Iñiguez C, Lertxundi N, Gascón M, Rebagliato M, Ballester F. Prenatal and postnatal insecticide use and infant neuropsychological development in a multicenter birth cohort study. Environ Int. 2013 Sep;59:175-82. PMID: 23831543
Swimming pool attendance, respiratory symptoms and infections in the first year of life
Font-Ribera L, Villanueva CM, Ballester F, Santa Marina L, Tardón A, Espejo-Herrera N, Esplugues A, Rodríguez Dehli C, Basterrechea M, Sunyer J. Swimming pool attendance, respiratory symptoms and infections in the first year of life. Eur J Pediatr .2013 Jul;172(7):977-85. PMID: 23468123
Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother-child cohort studies
Chatzi L, Garcia R, Roumeliotaki T, Basterrechea M, Begiristain H, Iñiguez C, Vioque J, Kogevinas M, Sunyer J. Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother-child cohort studies. Br J Nutr. 2013 Dec 14;110(11):2058-68. PMID: 23680284
The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life
Casas L, Zock JP, Carsin AE, Fernandez-Somoano A, Esplugues A, Santa-Marina L, Tardón A, Ballester F, Basterrechea M, Sunyer J. The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life. Int J Public Health. 2013 Oct;58(5):757-64. PMID: 23064260
Socio-Economic Inequalities in Health, Habits and Self-Care During Pregnancy in Spain
Larrañaga I, Santa-Marina L, Begiristain H, Machón M, Vrijheid M, Casas M, Tardón A, Fernández-Somoano A, Llop S, Rodriguez-Bernal CL, Fernandez MF. Socio-Economic Inequalities in Health, Habits and Self-Care During Pregnancy in Spain. Matern Child Health J. 2013 Sep;17(7):1315-24. PMID: 22983810
Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research
Larsen PS, Kamper-Jørgensen M, Adamson A, Barros H, Bonde JP, Brescianini S, Brophy S, Casas M, Devereux G, Eggesbø M, Fantini MP, Frey U, Gehring U, Grazuleviciene R, Henriksen TB, Hertz-Picciotto I, Heude B, Hryhorczuk DO, Inskip H, Jaddoe VW, Lawl. Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research. Paediatr Perinat Epidemiol. 2013 Jul;27(4):393-414. PMID: 23772942
Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study
Aurrekoetxea JJ, Murcia M, Rebagliato M, López MJ, Castilla AM, Santa-Marina L, Guxens M, Fernández-Somoano A, Espada M, Lertxundi A, Tardón A, Ballester F. Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study. BMJ Open. 2013 Jan 24;3(1).
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