Gipuzkoa
Al maig de 2006, es va posar en marxa a Guipúscoa el projecte “INfància i Medi Ambient (INMA)” per tal d’avaluar el paper dels contaminants ambientals presents en l’aire, en l’aigua i en la dieta en el creixement i desenvolupament dels infants. La incorporació de les mares a la cohort es va fer coincidir amb la primera ecografia de control de l’embaràs. Es van recollir mostres biològiques (sang, orina, cabell, placenta, etc.) i els van fer omplir diversos qüestionaris (general, dieta, laboral, ambiental, etc.). Després es va fer la valoració dels contaminants presents en l’aire i en l’aigua de consum, així com una estimació dels contaminants que aportava la dieta.
L’àmbit geogràfic d’estudi ve definit per la població de referència de l’Hospital Zumarraga, que inclou els municipis de Goierri i de l’Alt i Mitjà Urola. Aquest entorn es va seleccionar per les característiques del servei de l’Hospital i l’atenció primària implicats, així com per les característiques ambientals: presència massiva d’indústries siderometal·lúrgiques, alta densitat de trànsit, els nivells baixos de productes derivats de la desinfecció en l’aigua de consum i una dieta rica en peix, units a un cert grau d’hipotiroïdisme en les dones embarassades.
Des de llavors, s’ha fet el seguiment de 640 dones en el primer i tercer trimestre de l’embaràs. Actualment, s’està fent el seguiment de 623 nens en aspectes de creixement i de desenvolupament neuroconductual.
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Finançadors de la cohort INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entitats Col·laboradores:
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Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study
Valera-Gran D, Navarrete-Muñoz EM, Garcia de la Hera M, Fernández-Somoano A, Tardón A, Ibarluzea J, Balluerka N, Murcia M, González-Safont L, Romaguera D, Julvez J, Vioque J; INMA Project. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study. Am J Clin Nutr. 2017 Sep;106(3):878-887. PMID: 28724645
Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption
Llop S, Ballester F, Murcia M, Forns J, Tardon A, Andiarena A, Vioque J, Ibarluzea J, Fernández-Somoano A, Sunyer J, Julvez J, Rebagliato M, Lopez-Espinosa MJ. Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption. Int J Epidemiol. 2017 Jun 1;46(3):827-838. PMID: 27864405
Are Early Physical Activity and Sedentary Behaviors Related to Working Memory at 7 and 14 Years of Age?
López-Vicente M, Garcia-Aymerich J, Torrent-Pallicer J, Forns J, Ibarluzea J, Lertxundi N, González L, Valera-Gran D, Torrent M, Dadvand P, Vrijheid M, Sunyer J. Are Early Physical Activity and Sedentary Behaviors Related to Working Memory at 7 and 14 Years of Age?. J Pediatr. 2017 Sep;188:35-41. PMID: 28688631
Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study
Casas M, Forns J, Martínez D, Guxens M, Fernandez-Somoano A, Ibarluzea J, Lertxundi N, Murcia M, Rebagliato M, Tardon A, Sunyer J, Vrijheid M. Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study. Pediatr Res. 2017 Oct;82(4):596-606. PMID: 28493861
Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts
Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, Cordier S, de Groot R, den Dekker HT, Duijts L, Eggesbø M, Pia Fantini M, Forastiere F, Gehring U, Gielen M, Gori D, Govarts E, Inskip HM, Iszatt N, Jansen M, Kelleher C, Mehegan J, Moltó-Puigmartí C, Mommers M, Oliveira A, Olsen SF, Pelé F, Pizzi C, Porta D, Richiardi L, Rifas-Shiman SL, Robinson SM, Schoeters G, Strøm M, Sunyer J, Thijs C, Vrijheid M, Vrijkotte TG, Wijga AH, Kogevinas M, Zeegers MP, Chatzi L. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol. 2017 Oct 1;46(5):1465-1477. PMID: 28338907
Urinary Arsenic Speciation in Children and Pregnant Women from Spain
Signes-Pastor AJ, Carey M, Vioque J, Navarrete-Muñoz EM, Rodríguez-Dehli C, Tardón A, Begoña-Zubero M, Santa-Marina L, Vrijheid M, Casas M, Llop S, Gonzalez-Palacios S, Meharg AA. Urinary Arsenic Speciation in Children and Pregnant Women from Spain. Expo Health. 2017;9(2):105-111. PMID: 28553665
Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts
Birks L, Guxens M, Papadopoulou E, Alexander J, Ballester F, Estarlich M, Gallastegi M, Ha M, Haugen M, Huss A, Kheifets L, Lim H, Olsen J, Santa-Marina L, Sudan M, Vermeulen R, Vrijkotte T, Cardis E, Vrijheid M. Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts. Environ Int. 2017 Jul;104:122-131. PMID: 28392066
Mother’s education and offspring asthma risk in 10 European cohort studies
Lewis KM, Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Zvinchuk O, Saurel-Cubizolles MJ, Lioret S, Annesi-Maesano I, Vrijheid M, Torrent M, Iniguez C, Larranaga I, Harskamp-van Ginkel MW, Vrijkotte TGM, Klanova J, Svancara J, Barross H, Correia S, Jarvelin MR, Taanila A, Ludvigsson J, Faresjo T, Marmot M, Pikhart H. Mother’s education and offspring asthma risk in 10 European cohort studies. Eur J Epidemiol. 2017 Sep;32(9):797-805. PMID: 28929268
Prenatal and postnatal exposure to NO(2) and child attentional function at 4-5years of age
Sentís A, Sunyer J, Dalmau-Bueno A, Andiarena A, Ballester F, Cirach M, Estarlich M, Fernández-Somoano A, Ibarluzea J, Íñiguez C, Lertxundi A, Tardón A, Nieuwenhuijsen M, Vrijheid M, Guxens M; INMA Project. Prenatal and postnatal exposure to NO(2) and child attentional function at 4-5years of age. Environ Int. 2017 Sep;106:170-177. PMID: 28689118
Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García de la Hera M, Sunyer J, Casas M, Riaño-Galán I, Tardón A, Llop S, Amorós R, Amiano P, Bilbao JR, Karagas MR, Meharg AA. Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environ Res. 2017 Nov;159:69-75. PMID: 28772151
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