Resultats de l’estudi
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV; Early Growth Genetics Consortium, Grant SFA. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019 Oct 1;28(19):3327-3338. PMID: 31504550
High adherence to a mediterranean diet at age 4 reduces overweight, obesity and abdominal obesity incidence in children at the age of 8
Notario-Barandiaran L, Valera-Gran D, Gonzalez-Palacios S, Garcia-de-la-Hera M, Fernández-Barrés S, Pereda-Pereda E, Fernández-Somoano A, Guxens M, Iñiguez C, Romaguera D, Vrijheid M, Tardón A, Santa-Marina L, Vioque J, Navarrete-Muñoz EM; INMA Project. High adherence to a mediterranean diet at age 4 reduces overweight, obesity and abdominal obesity incidence in children at the age of 8. Int J Obes (Lond). 2020 Sep;44(9):1906-1917. PMID: 32152497
Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium
Howe CG, Cox B, Fore R, Jungius J, Kvist T, Lent S, Miles HE, Salas LA, Rifas-Shiman S, Starling AP, Yousefi P, Ladd-Acosta C, Baccarelli A, Binder EB, Chatzi VL, Czamara D, Dabelea D, DeMeo DL, Ghantous A, Herceg Z, Kajantie E, Lahti JMT, Lawlor DA, Litonjua A, Nawrot TS, Nohr EA, Oken E, Pizzi C, Plusquin M, Räikkönen K, Relton CL, Sharp GC, Sørensen TIA, Sunyer J, Vrijheid M, Zhang W, Hivert MF, Breton CV. Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium. Diabetes Care. 2020 Jan;43(1):98-105. PMID: 31601636
Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain)
Lozano M, Murcia M, Soler-Blasco R, Iñiguez C, Irizar A, Lertxundi A, Basterrechea M, Marina LS, Amorós R, Broberg K, Ballester F, Llop S. Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain). Environ Res. 2020 Feb;181:108943. PMID: 31791709
Early-Life Environmental Exposures and Blood Pressure in Children
Warembourg C, Maitre L, Tamayo-Uria I, Fossati S, Roumeliotaki T, Aasvang GM, Andrusaityte S, Casas M, Cequier E, Chatzi L, Dedele A, Gonzalez JR, Gražulevičienė R, Haug LS, Hernandez-Ferrer C, Heude B, Karachaliou M, Krog NH, McEachan R, Nieuwenhuijsen M, Petraviciene I, Quentin J, Robinson O, Sakhi AK, Slama R, Thomsen C, Urquiza J, Vafeiadi M, West J, Wright J, Vrijheid M, Basagaña X. Early-Life Environmental Exposures and Blood Pressure in Children. J Am Coll Cardiol. 2019 Sep 10;74(10):1317-1328. PMID: 31488269
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Couto Alves A, De Silva NMG, Karhunen V, Sovio U, Das S, Taal HR, Warrington NM, Lewin AM, Kaakinen M, Cousminer DL, Thiering E, Timpson NJ, Bond TA, Lowry E, Brown CD, Estivill X, Lindi V, Bradfield JP, Geller F, Speed D, Coin LJM, Loh M, Barton SJ, Beilin LJ, Bisgaard H, Bønnelykke K, Alili R, Hatoum IJ, Schramm K, Cartwright R, Charles MA, Salerno V, Clément K, Claringbould AAJ; BIOS Consortium, van Duijn CM, Moltchanova E, Eriksson JG, Elks C, Feenstra B, Flexeder C, Franks S, Frayling TM, Freathy RM, Elliott P, Widén E, Hakonarson H, Hattersley AT, Rodriguez A, Banterle M, Heinrich J, Heude B, Holloway JW, Hofman A, Hyppönen E, Inskip H, Kaplan LM, Hedman AK, Läärä E, Prokisch H, Grallert H, Lakka TA, Lawlor DA, Melbye M, Ahluwalia TS, Marinelli M, Millwood IY, Palmer LJ, Pennell CE, Perry JR, Ring SM, Savolainen MJ, Rivadeneira F, Standl M, Sunyer J, Tiesler CMT, Uitterlinden AG, Schierding W, O’Sullivan JM, Prokopenko I, Herzig KH, Smith GD, O’Reilly P, Felix JF, Buxton JL, Blakemore AIF, Ong KK, Jaddoe VWV, Grant SFA, Sebert S, McCarthy MI, Järvelin MR; Early Growth Genetics (EGG) Consortium. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Sci Adv. 2019 Sep 4;5(9):eaaw3095. PMID: 31840077
Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study
Arija V, Hernández-Martínez C, Tous M, Canals J, Guxens M, Fernández-Barrés S, Ibarluzea J, Babarro I, Soler-Blasco R, Llop S, Vioque J, Sunyer J, Julvez J. Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study. Nutrients. 2019 Dec 7;11(12). PMID: 31817835
Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood
López-Vicente M, Sunyer J, Lertxundi N, González L, Rodríguez-Dehli C, Espada Sáenz-Torre M, Vrijheid M, Tardón A, Llop S, Torrent M, Ibarluzea J, Guxens M. Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood. Sci Rep. 2019 Oct 15;9(1):14792. PMID: 31616023
Sugar-Containing Beverages Consumption and Obesity in Children Aged 4-5 Years in Spain: the INMA Study
Gonzalez-Palacios S, Navarrete-Muñoz EM, García-de-la-Hera M, Torres-Collado L, Santa-Marina L, Amiano P, Lopez-Espinosa MJ, Tardon A, Riano-Galan I, Vrijheid M, Sunyer J, Vioque J. Sugar-Containing Beverages Consumption and Obesity in Children Aged 4-5 Years in Spain: the INMA Study. Nutrients. 2019 Aug 1;11(8). PMID: 31374897
Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts
Jorcano A, Lubczyńska MJ, Pierotti L, Altug H, Ballester F, Cesaroni G, El Marroun H, Fernández-Somoano A, Freire C, Hanke W, Hoek G, Ibarluzea J, Iñiguez C, Jansen PW, Lepeule J, Markevych I, Polańska K, Porta D, Schikowski T, Slama R, Standl M, Tardon A, Vrijkotte TGM, von Berg A, Tiemeier H, Sunyer J, Guxens M. Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts. Environ Int. 2019 Oct;131:104927. PMID: 31326824
Prenatal exposure to organochlorine compounds and lung function during childhood
Abellan A, Sunyer J, Garcia-Esteban R, Basterrechea M, Duarte-Salles T, Ferrero A, Garcia-Aymerich J, Gascon M, Grimalt JO, Lopez-Espinosa MJ, Zabaleta C, Vrijheid M, Casas M. Prenatal exposure to organochlorine compounds and lung function during childhood. Environ Int. 2019 Oct;131:105049. PMID: 31362153
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J, Mahajan A, Bradfield JP, Lin FTJ, Vogelezang S, Bustamante M, Ahluwalia TS, Pitkänen N, Wang CA, Bacelis J, Borges MC, Zhang G, Bedell BA, Rossi RM, Skogstrand K, Peng S, Thompson WK, Appadurai V, Lawlor DA, Kalliala I, Power C, McCarthy MI, Boyd HA, Marazita ML, Hakonarson H, Hayes MG, Scholtens DM, Rivadeneira F, Jaddoe VWV, Vinding RK, Bisgaard H, Knight BA, Pahkala K, Raitakari O, Helgeland Ø, Johansson S, Njølstad PR, Fadista J, Schork AJ, Nudel R, Miller DE, Chen X, Weirauch MT, Mortensen PB, Børglum AD, Nordentoft M, Mors O, Hao K, Ryckman KK, Hougaard DM, Kottyan LC, Pennell CE, Lyytikainen LP, Bønnelykke K, Vrijheid M, Felix JF, Lowe WL Jr, Grant SFA, Hyppönen E, Jacobsson B, Jarvelin MR, Muglia LJ, Murray JC, Freathy RM, Werge TM, Melbye M, Buil A, Feenstra B. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nat Commun. 2019 Sep 2;10(1):3927. doi: 10.1038/s41467-019-11881-8. PMID: 31477735
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
Sikdar S, Joehanes R, Joubert BR, Xu CJ, Vives-Usano M, Rezwan FI, Felix JF, Ward JM, Guan W, Richmond RC, Brody JA, Küpers LK, Baïz N, Håberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, Consortium TB, Bakulski KM, Melen E, Zhao S, Jin J, Herceg Z, Meurs JV, Taylor JA, Baccarelli AA, Murphy SK, Liu Y, Munthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics. 2019 Oct;11(13):1487-1500. PMID: 31536415
Obesity is associated with shorter telomeres in 8 year-old children
Clemente DBP, Maitre L, Bustamante M, Chatzi L, Roumeliotaki T, Fossati S, Grazuleviciene R, Gützkow KB, Lepeule J, Martens DS, McEachan RRC, Meltzer HM, Petraviciene I, Slama R, Tamayo-Uria I, Urquiza J, Vafeiadi M, Wright J, Nawrot TS, Vrijheid M. Obesity is associated with shorter telomeres in 8 year-old children. Sci Rep. 2019 Dec 10;9(1):18739. PMID: 31822763
Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries
Papadopoulou E, Haug LS, Sakhi AK, Andrusaityte S, Basagaña X, Brantsaeter AL, Casas M, Fernández-Barrés S, Grazuleviciene R, Knutsen HK, Maitre L, Meltzer HM, McEachan RRC, Roumeliotaki T, Slama R, Vafeiadi M, Wright J, Vrijheid M, Thomsen C, Chatzi L. Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries. Environ Health Perspect. 2019 Oct;127(10):107005. PMID: 31617753
Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project
Clemente DBP, Vrijheid M, Martens DS, Bustamante M, Chatzi L, Danileviciute A, de Castro M, Grazuleviciene R, Gutzkow KB, Lepeule J, Maitre L, McEachan RRC, Robinson O, Schwarze PE, Tamayo I, Vafeiadi M, Wright J, Slama R, Nieuwenhuijsen M, Nawrot TS. Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project. Environ Health Perspect. 2019 Aug;127(8):87001. PMID: 31393792
Causal Effects of Prenatal Exposure to PM2.5 on Child Development and the Role of Unobserved Confounding
Tozzi V, Lertxundi A, Ibarluzea JM, Baccini M. Causal Effects of Prenatal Exposure to PM2.5 on Child Development and the Role of Unobserved Confounding. Int J Environ Res Public Health. 2019 Nov 9;16(22). PMID: 31717528
Mother-child transfer rates of organohalogen compounds up to four years of age
Garí M, Grimalt JO, Vizcaino E, Tardón A, Fernández-Somoano A. Mother-child transfer rates of organohalogen compounds up to four years of age. Environ Int. 2019 Dec;133(Pt B):105241. PMID: 31648152
Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
Agier L, Basagaña X, Maitre L, Granum B, Bird PK, Casas M, Oftedal B, Wright J, Andrusaityte S, de Castro M, Cequier E, Chatzi L, Donaire-Gonzalez D, Grazuleviciene R, Haug LS, Sakhi AK, Leventakou V, McEachan R, Nieuwenhuijsen M, Petraviciene I, Robinson O, Roumeliotaki T, Sunyer J, Tamayo-Uria I, Thomsen C, Urquiza J, Valentin A, Slama R, Vrijheid M, Siroux V. Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort. Lancet Planet Health. 2019 Feb;3(2):e81-e92. PMID: 30737192
Association of maternal iodine status with child IQ: a meta-analysis of individual-participant data
Levie D, Korevaar TIM, Bath SC, Murcia M, Dineva M, Llop S, Espada M, van Herwaarden AE, de Rijke YB, Ibarluzea JM, Sunyer J, Tiemeier H, Rayman MP, Guxens M, Peeters RP. Association of maternal iodine status with child IQ: a meta-analysis of individual-participant data. J Clin Endocrinol Metab. 2019 Dec 1;104(12):5957-596. PMID: 30920622
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