Resultats de l’estudi
Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
Sharp GC, Alfano R, Ghantous A, Urquiza J, Rifas-Shiman SL, Page CM, Jin J, Fernández-Barrés S, Santorelli G, Tindula G; 36 other members of the Pregnancy and Childhood Epigenetics (PACE) consortium. Paternal body mass index and offspring DNA methylation: findings from the PACE consortium. Int J Epidemiol. 2021 Aug 30;50(4):1297-1315. PMID: 33517419
Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
Maitre L, Julvez J, López-Vicente M, Warembourg C, Tamayo-Uria I, Philippat C, Gützkow KB, Guxens M, Andrusaityte S, Basagaña X, Casas M, de Castro M, Chatzi L, Evandt J, Gonzalez JR, Gražulevičienė R, Smastuen Haug L, Heude B, Hernandez-Ferrer C, Kampouri M, Manson D, Marquez S, McEachan R, Nieuwenhuijsen M, Robinson O, Slama R, Thomsen C, Urquiza J, Vafeidi M, Wright J, Vrijheid M. Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study. Environ Int. 2021 Aug;153:106523. PMID: 33773142
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L; BIOS Consortium, Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry. 2021 Jun;26(6):2148-2162. PMID: 33420481
Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation
Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Mol Psychiatry. 2021 Jun;26(6):1832-1845. PMID: 33414500
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Estrada Gutierrez G, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler AG, Annesi-Maesano I, Bustamante M, Huang RC, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin MR, Felix JF, Sebert S. Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium. Epigenetics. 2022 Jan;17(1):19-31. PMID: 33331245
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramís G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergström A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Håberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monnereau C, Mori TA, Oken E, Räikkönen K, Rifas-Shiman S, Ruiz-Arenas C, Sebert S, Ullemar V, Verduci E, Vonk JM, Xu CJ, Yang IV, Zhang H, Zhang W, Karmaus W, Dabelea D, Muhlhausler BS, Breton CV, Lahti J, Almqvist C, Jarvelin MR, Koletzko B, Vrijheid M, Sørensen TIA, Huang RC, Arshad SH, Nystad W, Melén E, Koppelman GH, London SJ, Holland N, Bustamante M, Murphy SK, Hivert MF, Baccarelli A, Relton CL, Snieder H, Jaddoe VWV, Felix JF. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Med. 2020 Nov 25;12(1):105. PMID: 33239103
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
Neumann A, Walton E, Alemany S, Cecil C, González JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, Caramaschi D, Carracedo Á, Czamara D, Evandt J, Felix JF, Fuemmeler BF, Gutzkow KB, Hoyo C, Julvez J, Kajantie E, Laivuori H, Maguire R, Maitre L, Murphy SK, Murcia M, Villa PM, Sharp G, Sunyer J, Raikkönen K, Bakermans-Kranenburg M, IJzendoorn MV, Guxens M, Relton CL, Tiemeier H. Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis. Transl Psychiatry. 2020 Nov 12;10(1):398.
PMID: 33184255
In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood
Stratakis N, Golden-Mason L, Margetaki K, Zhao Y, Valvi D, Garcia E, Maitre L, Andrusaityte S, Basagana X, Borràs E, Bustamante M, Casas M, Fossati S, Grazuleviciene R, Haug LS, Heude B, McEachan RRC, Meltzer HM, Papadopoulou E, Roumeliotaki T, Robinson O, Sabidó E, Urquiza J, Vafeiadi M, Varo N, Wright J, Vos MB, Hu H, Vrijheid M, Berhane KT, Conti DV, McConnell R, Rosen HR, Chatzi L. In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood. Hepatology. 2021 Sep;74(3):1546-1559. PMID: 33730435
Urinary metabolite quantitative trait loci in children and their interaction with dietary factors
Calvo-Serra B, Maitre L, Lau CE, Siskos AP, Gützkow KB, Andrušaitytė S, Casas M, Cadiou S, Chatzi L, González JR, Grazuleviciene R, McEachan R, Slama R, Vafeiadi M, Wright J, Coen M, Vrijheid M, Keun HC, Escaramís G, Bustamante M. Urinary metabolite quantitative trait loci in children and their interaction with dietary factors. Hum Mol Genet. 2021 Feb 4;29(23):3830-3844. doi: 10.1093/hmg/ddaa257.
PMID: 33283231
Maternal sleep duration and neonate birth weight: A population-based cohort study
Marinelli M, Carsin AE, Turner MC, Fernández-Somoano A, Rodriguez-Dehli AC, Basterrechea M, Santa-Marina L, Iñiguez C, Lopez-Espinosa MJ, Sunyer J, Julvez J. Maternal sleep duration and neonate birth weight: A population-based cohort study. Int J Gynaecol Obstet. 2022 Mar;156(3):494-501. PMID: 33754347
Prenatal Exposure to Multiple Air Pollutants, Mediating Molecular Mechanisms, and Shifts in Birthweight
Laine JE, Bodinier B, Robinson O, Plusquin M, Scalbert A, Keski-Rahkonen P, Robinot N, Vermeulen R, Pizzi C, Asta F, Nawrot T, Gulliver J, Chatzi L, Kogevinas M, Nieuwenhuijsen M, Sunyer J, Vrijheid M, Chadeau-Hyam M, Vineis P. Prenatal Exposure to Multiple Air Pollutants, Mediating Molecular Mechanisms, and Shifts in Birthweight. Environ Sci Technol. 2020 Nov 17;54(22):14502-14513. doi: 10.1021/acs.est.0c02657. Epub 2020 Oct 30. PMID: 33124810
The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project
Compañ Gabucio LM, García de la Hera M, Torres Collado L, Fernández-Somoano A, Tardón A, Guxens M, Vrijheid M, Rebagliato M, Murcia M, Ibarluzea J, Martí I, Vioque J. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project. Nutrients. 2021 Jan 23;13(2):327. PMID: 33498619
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents
Güil-Oumrait N, Valvi D, Garcia-Esteban R, Guxens M, Sunyer J, Torrent M, Casas M, Vrijheid M. Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents. Environ Int. 2021 Jun;151:106469. PMID: 33711537
Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts
Jedynak P, Maitre L, Guxens M, Gützkow KB, Julvez J, López-Vicente M, Sunyer J, Casas M, Chatzi L, Gražulevičienė R, Kampouri M, McEachan R, Mon-Williams M, Tamayo I, Thomsen C, Urquiza J, Vafeiadi M, Wright J, Basagaña X, Vrijheid M, Philippat C. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts. Sci Total Environ. 2021 Apr 1;763:144115. PMID: 33422710
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM 2.5 exposure
Merid SK, Bustamante M, Standl M, Sunyer J, Heinrich J, Lemonnier N, Aguilar D, Antó JM, Bousquet J, Santa-Marina L, Lertxundi A, Bergström A, Kull I, Wheelock ÅM, Koppelman GH, Melén E, Gruzieva O. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM 2.5 exposure. Environ Int. 2021 Jan;146:106248.
PMID: 33212358
Shared DNA methylation signatures in childhood allergy: The MeDALL study
Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G; BIOS Consortium, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021 Mar;147(3):1031-1040. PMID: 33338541
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, Heiskala A, Horikoshi M, Fedko IO, Vilor-Tejedor N, Cousminer DL, Standl M, Wang CA, Viikari J, Geller F, Íñiguez C, Pitkänen N, Chesi A, Bacelis J, Yengo L, Torrent M, Ntalla I, Helgeland Ø, Selzam S, Vonk JM, Zafarmand MH, Heude B, Farooqi IS, Alyass A, Beaumont RN, Have CT, Rzehak P, Bilbao JR, Schnurr TM, Barroso I, Bønnelykke K, Beilin LJ, Carstensen L, Charles MA, Chawes B, Clément K, Closa-Monasterolo R, Custovic A, Eriksson JG, Escribano J, Groen-Blokhuis M, Grote V, Gruszfeld D, Hakonarson H, Hansen T, Hattersley AT, Hollensted M, Hottenga JJ, Hyppönen E, Johansson S, Joro R, Kähönen M, Karhunen V, Kiess W, Knight BA, Koletzko B, Kühnapfel A, Landgraf K, Langhendries JP, Lehtimäki T, Leinonen JT, Li A, Lindi V, Lowry E, Bustamante M, Medina-Gomez C, Melbye M, Michaelsen KF, Morgen CS, Mori TA, Nielsen TRH, Niinikoski H, Oldehinkel AJ, Pahkala K, Panoutsopoulou K, Pedersen O, Pennell CE, Power C, Reijneveld SA, Rivadeneira F, Simpson A, Sly PD, Stokholm J, Teo KK, Thiering E, Timpson NJ, Uitterlinden AG, van Beijsterveldt CEM, van Schaik BDC, Vaudel M, Verduci E, Vinding RK, Vogel M, Zeggini E, Sebert S, Lind MV, Brown CD, Santa-Marina L, Reischl E, Frithioff-Bøjsøe C, Meyre D, Wheeler E, Ong K, Nohr EA, Vrijkotte TGM, Koppelman GH, Plomin R, Njølstad PR, Dedoussis GD, Froguel P, Sørensen TIA, Jacobsson B, Freathy RM, Zemel BS, Raitakari O, Vrijheid M, Feenstra B, Lyytikäinen LP, Snieder H, Kirsten H, Holt PG, Heinrich J, Widén E, Sunyer J, Boomsma DI, Järvelin MR, Körner A, Davey Smith G, Holm JC, Atalay M, Murray C, Bisgaard H, McCarthy MI; Early Growth Genetics Consortium, Jaddoe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020 Oct 12;16(10):e1008718. PMID: 33045005
Urban environment during early-life and blood pressure in young children
Warembourg C, Nieuwenhuijsen M, Ballester F, de Castro M, Chatzi L, Esplugues A, Heude B, Maitre L, McEachan R, Robinson O, Slama R, Sunyer J, Urquiza J, Wright J, Basagaña X, Vrijheid M. Urban environment during early-life and blood pressure in young children. Environ Int. 2021 Jan;146:106174. PMID: 33099063.
Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study
Santa-Marina L, Lertxundi N, Andiarena A, Irizar A, Sunyer J, Molinuevo A, Llop S, Julvez J, Beneito A, Ibarluzea J, Imaz L, Ferrin M. Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study. Int J Environ Res Public Health. 2020 Oct 22;17(21):7704. PMID: 33105572.
Urinary cobalt and ferritin in four-years-old children
Junqué E, Grimalt JO, Fernández-Somoano A, Tardón A. Urinary cobalt and ferritin in four-years-old children. Environ Res. 2020 Apr;183:109147.
PMID: 32000000.
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