Resultats de l’estudi
Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis
Yu Z, Fontes Marques I, Kebede Merid S, Burrows K, Soares AG, Pyko A, Ögren M, Pershagen G, Lepeule J, Hjertager Krog N, Aasvang GM, Kusters MSW, Foraster M, Bustamante M, Leskien M, Thiering E, Elhakeem A, Peters A, Koppelman GH, Gehring U, Vonk JM, Jeong A, Imboden M, Probst-Hensch N, Vermeulen R, Nieuwenhuijsen M, Guxens M, Standl M, Jaddoe VWJ, London SJ, Melén E, Felix JF, Gruzieva O. Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis. Environ Int. 2026 Jan;207:109976. PMID: 41352164
Determinants of overweight and obesity and other cardiometabolic risks in adolescents: a Spanish longitudinal birth study
Lozano M, Vallejo-Ortega J, Marín N, González-Safont L, Esplugues A, Lopez-Espinosa MJ, Beneito A, González-Palacios S, Llop S, Soler-Blasco R. Determinants of overweight and obesity and other cardiometabolic risks in adolescents: a Spanish longitudinal birth study. Pediatr Res. 2025 Dec;98(6):2087-2100. PMID: 40681697
Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity
Hernangomez-Laderas A, Cilleros-Portet A, Marí S, González-García BP, Arregi A, Jimeno-Romero A, Irizar A, García-Santisteban I, Lesseur C, Fernandez-Jimenez N, Bilbao JR. Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity. NPJ Genom Med. 2025 Jun 20;10(1):49. PMID: 40541940
Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort
San Román A, Abilleira E, González-Gaya B, Ayala-Cabrera JF, Barroeta Z, Etxebarria N, Irizar A. Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort. Environ Res. 2025 Oct 15;283:122198. PMID: 40543869.
The Association Between the Mediterranean Diet and Fatty Acids in Red Blood Cells of Spanish Adolescents
Ayala-Aldana N, Lafuente D, Lázaro I, Pinar-Martí A, Manidis A, Bernardo-Castro S, Fernandez-Barres S, Healy DR, Vrijheid M, Contreras-Rodríguez O, Sala-Vila A, Julvez J. The Association Between the Mediterranean Diet and Fatty Acids in Red Blood Cells of Spanish Adolescents. Nutrients. 2025 Sep 6;17(17):2888. PMID: 40944276
Red Blood Cell Fatty Acid Patterns and Cognitive Functions in Adolescents: A Pooled Analyses with Two Cohort Study Data Sets
Ayala-Aldana N, Pinar-Martí A, Ruiz-Rivera M, Lázaro I, Sala-Vila A, Healy DR, Contreras-Rodriguez O, Casanova J, Sola-Valls N, Vrijheid M, Julvez J. Red Blood Cell Fatty Acid Patterns and Cognitive Functions in Adolescents: A Pooled Analyses with Two Cohort Study Data Sets. Nutrients. 2025 Nov 5;17(21):3483. PMID: 41228554
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies
Standl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J, Herrera-Luis E, Holloway JW, Hottenga J, O’B Hourihane J, Hu C, Hveem K, Irizar A, Jacquemin B, Jessen L, Kress S, Kurukulaaratchy RJ, Lau S, Llop S, Løset M, Marenholz I, Mason D, McCartney DL, Melbye M, Melén E, Minica C, Murray CS, Nijsten T, Pardo LM, Pasmans S, Pennell CE, Rinnov MR, Santorelli G, Schikowski T, Sheehan D, Simpson A, Söderhäll C, Thomas LF, Thyssen JP, Torrent M, van Beijsterveldt T, Visconti A, Vonk JM, Wang CA, Xu CJ, Ziyab AH; UK Translational Research Network in Dermatology; BIOMAP Consortium; Custovic A, Di Meglio P, Duijts L, Flohr C, Irvine AD, Koppelman GH, Lee YA, Reynolds NJ, Smith C, Langan SM, Paternoster L, Brown SJ. Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies. Allergy. 2025 Aug;80(8):2201-2212. PMID: 40462597. Erratum in: Allergy. 2026 Feb;81(2):626. PMID: 40958161 .
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
Osinga JAJ, Derakhshan A, Karachaliou M, Poppe KG, Warringa L, Verdonk K, Vaidya B, Männistö T, López-Bermejo A, Bassols J, Broeren MAC, Brown SJ, Jensen RC, Popova PV, Pop VJM, Feldt-Rasmussen U, Aminorroaya A, Bliddal S, Mosso L, Chatzi L, Boucai L, Itoh S, Kishi R, Kleynen P, Ashoor G, Oken E, Grineva EN, Lu X, Lertxundi A, Murcia M, Meertens-Gunput STG, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Fernández-Somoano A, Suvanto E, Guxens M, Daraki V, Mathieu C, Kianpour M, Glintborg D, Jensen TK, Alexander E, Chaker L, Malone F, Messerlian G, Hattersley A, Harley KG, Pearce EN, Visser WE, Vrijkotte TGM, Peeters RP, Palomaki GE, Lowe W, Eskenazi B, Chen LM, Walsh JP, Nicolaides KH, Carty DM, Delles C, Tao FB, Huang K, Maraka S, D’Alton ME, Painter RC, Andersen MS, Benhalima K, Korevaar TIM. Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis. Lancet Diabetes Endocrinol. 2025 Aug;13(8):651-661. PMID: 40609565
Early nursery attendance and infant neurodevelopment at 1 year of age
L. González-Safont, P. Carrasco, R. Abumallouh, S. Llop, M. Estarlich & M. Rebagliato. Early nursery attendance and infant neurodevelopment at 1 year of age. Early Child Development and Care 2025, 195:7-8, 744-760
Link to this article: https://doi.org/10.1080/03004430.2025.2528843
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes
van der Laan CM, Ip HF, Schipper M, Hottenga JJ, St Pourcain B, Zayats T, Pool R, Krapohl EML, Brikell I, Soler Artigas M, Cabana-Domínguez J, Llonga N, Nolte IM, Bolhuis K, Palviainen T, Zafarmand H, Gordon S, Aliev F, Burt SA, Wang CA, Saunders G, Karhunen V, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Vilor-Tejedor N, Ahluwalia TS, Allegrini A, Rimfeld K, Chen Q, Lu Y, Martin J, Bosch R, Ramos-Quiroga JA, Neumann A, Ensink J, Grasby KL, Morosoli JJ, Tong X, Marrington S, Scott JG, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ehli EA, Hagenbeek FA, Derks EM, Larsson H, Snieder H, Cecil C, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds CA, Smolen A, Stallings M, Wadsworth S, Wall TL, Eaves L, Silberg JL, Miller A, Havdahl A, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Sunyer J, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood J, Kennedy M, Poulton R, Maes HH, Hewitt J, Copeland WE, Middeldorp CM, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse AJO, Pennell CE, Klump KL, Jiang C, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI. Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nat Genet. 2025 Oct;57(10):2427-2435. PMID: 40962958. Erratum in: Nat Genet. 2025 Oct;57(10):2604. PMID: 41023451.
Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms
Lozano M, Soler-Blasco R, Ballester F, Gutzkow KB, Brantsæter AL, Karachaliou M, Stephanou EG, Symvoulakis EK, Grazuleviciene R, Andrusaityte S, Dedele A, Yang TC, McEachan RRC, Wright J, Heude B, Yuan WL, Vrijheid M, Maitre L, Stratakis N, Thomsen C, Nawrot T, Broberg K, Llop S. Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms. Environ Int. 2025 Nov;205:109880. PMID: 41205373
Prenatal and childhood exposure to mixtures of environmental chemicals and adolescence attentional problems: a triangulation study
Fabbri L, Andrušaitytė S, Basagaña X, Bhopal S, Bustamante M, Cheung RW, Gražulevičienė R, Guxens M, Kadawathagedara M, Kampouri M, Maitre L, Marquez S, Montazeri P, Myridakis A, Slama R, Thomsen C, Vrijheid M. Prenatal and childhood exposure to mixtures of environmental chemicals and adolescence attentional problems: a triangulation study. Environ Int. 2025 Dec;206:109927. PMID: 41252940
Early-life exposome and health-related immune signatures in childhood
Amine I, Anguita-Ruiz A, Guillien A, Basagaña X, Bustamante M, Borràs E, Cirach M, Dedele A, Dobaño C, Garcia-Aymerich J, Granum B, Grazuleviciene R, González JR, Julvez J, Keun H, López-Vicente M, McEachan R, Moncunill G, Nieuwenhuijsen M, Sabidó E, Slama R, Tenenhaus A, Vafeiadi M, Wright J, Yang T, Yuan WL, Vrijheid M, Siroux V, Maitre L. Early-life exposome and health-related immune signatures in childhood. Environ Int. 2025 Aug;202:109668. PMID: 40651279
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Edwards K, Merrill SM, Konwar C, Jude MS, Zhuang BC, Meijer M, Navarro-Delgado E, MacIsaac JL, Mandhane P, Simons E, Moraes TJ, Azad MB, Subbarao P, Bustamante M, Vrijheid M, Turvey S, Kobor MS. Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system. Commun Biol. 2025 Oct 9;8(1):1447. PMID: 41068453
Maternal asthma and newborn DNA methylation
Pedersen CT, Hoang TT, Jin J, Starnawska A, Granell R, Elliott HR, Huels A, Zar HJ, Stein DJ, Zhang Y, Dekker HTD, Duijts L, Felix JF, Sangüesa J, Bustamante M, Casas M, Vrijheid M, Kadalayil L, Rezwan FI, Arshad H, Holloway JW, Röder S, Zenclussen AC, Herberth G, Staunstrup NH, Horsdal HT, Mill J, Hannon E; iPSYCH-MINERvA Group; Annesi-Maesano I, Pesce G, Baïz N, Heude B, Hosseinian-Mohazzab S, Breton CV, Harlid S, Harbs J, Domellof M, West C, Yeung E, Zeng X, Nystad W, Håberg SE, Magnus MC, Schendel D, London SJ, Bønnelykke K. Maternal asthma and newborn DNA methylation. Clin Epigenetics. 2025 May 10;17(1):79. PMID: 40349045
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Neumann A, Sammallahti S, Cosin-Tomas M, Reese SE, Suderman M, Alemany S, Almqvist C, Andrusaityte S, Arshad SH, Bakermans-Kranenburg MJ, Beilin L, Breton C, Bustamante M, Czamara D, Dabelea D, Eng C, Eskenazi B, Fuemmeler BF, Gilliland FD, Grazuleviciene R, Håberg SE, Herberth G, Holland N, Hough A, Hu D, Huen K, Hüls A, Jarvelin MR, Jin J, Julvez J, Koletzko BV, Koppelman GH, Kull I, Lu X, Maitre L, Mason D, Melén E, Merid SK, Molloy PL, Mori TA, Mulder RH, Page CM, Richmond RC, Röder S, Ross JP, Schellhas L, Sebert S, Sheppard D, Snieder H, Starling AP, Stein DJ, Tindula G, van IJzendoorn MH, Vonk J, Walton E, Witonsky J, Xu CJ, Yang IV, Yousefi PD, Zar HJ, Zenclussen AC, Zhang H, Tiemeier H, London SJ, Felix JF, Cecil C. Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium. Genome Med. 2025 Apr 14;17(1):39. PMID: 40229801
Outdoor air pollution, road traffic noise, and allostatic load in children aged 6-11 years: evidence from six European cohorts
Mou Y, Kusters MSW, Robinson O, Maitre L, McEachan RRC, Yuan WL, Hjertager Krog N, Andrušaitytė S, Bustamante M, de Castro Pascual M, Dedele A, Wright J, Grazuleviciene R, Aasvang GM, Lepeule J, Nieuwenhuijsen M, Tiemeier H, Vrijheid M, Thomson EM, Guxens M. Outdoor air pollution, road traffic noise, and allostatic load in children aged 6-11 years: evidence from six European cohorts. Eur J Epidemiol. 2025 May;40(5):537-548. PMID: 40366609
Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis
Rayinda T, Dand N, McSweeney SM, Christou E, Ung CY, Stefanato CM, Fenton DA, Harries M, Palamaras I, Tidman A, Holmes S, Koutalopoulou A, Ardern-Jones M, Kaur M, Papanikou S, Chasapi V, Vañó-Galvan S, Saceda-Corralo D, Melián-Olivera A, Azcarraga-Llobet C, Lobato-Berezo A, Bustamante M, Sunyer J, Starace MVR, Piraccini BM, Wiss IP, Senna MM, Singh R, Hillmann K, Kanti-Schmidt V, Blume-Peytavi U, McGrath JA, Simpson MA, Tziotzios C. Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis. JAMA Dermatol. 2025 Mar 1;161(3):310-314. PMID: 39937552
Genetic characterization of preschool wheeze phenotypes
Fischer-Rasmussen K, Granell R, Eliasen AU, Kreiner E, Pedersen CT, Luo Y, Chawes B, Stokholm J, Malby Schoos AM, Kumar A, Nybo Andersen AM, Feenstra B, Geller F, Siroux V, Demenais F, Bouzigon E, Jaddoe V, van der Valk RJP, Duijts L, Sunyer J, Guxens M, Marinelli M, Bustamante M, Heinrich J, Standl M, Curtin J, Simpson A, Murray C, Jacobsson B, Myhre R, Pennell CE, Daley D, Ober C, Gern JE, Jackson D, Boomsma DI, Hottenga JJ, Abdellaoui A, Holloway JW, Collins S, Turner S, Arshad SH, Ullah A, Melén E, Henderson J, Bisgaard H, Pedersen AG, Custovic A, Vonk JM, Koppelman GH, Kabesch M, Bønnelykke K; Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community (GABRIEL) consortium; EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. Genetic characterization of preschool wheeze phenotypes. J Allergy Clin Immunol. 2025 Dec;156(6):1537-1546. PMID: 40769318
Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts
Pinot de Moira A, Aurup AV, Avraam D, Zugna D, Jensen AKG, Welten M, Cadman T, de Lauzon-Guillain B, Duijts L, Elhakeem A, Esplugues A, Garcia-Aymerich J, García-Baquero G, González Safont L, Harris JR, Iñiguez C, Jaddoe VWV, McEachan RRC, Nader JLT, Santa Marina L, Swertz MA, Tafflet M, Vrijheid M, Wright J, Yang TC, Taylor-Robinson D, Richiardi L, Nybo Andersen AM. Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts. J Allergy Clin Immunol Pract. 2025 Jun;13(6):1385-1396. PMID: 40314625
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