Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Pre- and post-natal exposure to tobacco smoke and respiratory outcomes during the first year
Fuentes-Leonarte V, Estarlich M, Ballester F, Murcia M, Esplugues A, Aurrekoetxea JJ, Basterrechea M, Fernández-Somoano A, Morales E, Gascón M, Tardón A, Rebagliato M. Pre- and post-natal exposure to tobacco smoke and respiratory outcomes during the first year.Indoor Air. 2015 Feb;25(1):4-12. PMID: 24810295
Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age
Morales E, Garcia-Esteban R, Asensio de la Cruz O, Basterrechea M, Lertxundi A, Martinez López de Dicastillo MD, Zabaleta C, Sunyer J. Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age. Thorax. 2015 Jan;70(1):64-73. PMID: 25331281
Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers
Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, Chatzi L, Chevrier C, Eggesbø M, Fernandez MF, Govarts E, Guxens M, Grimalt JO, Hertz-Picciotto I, Iszatt N, Kasper-Sonnenberg M, Kiviranta H, Kogevinas M, Palkovicova L,. Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers. Environ Int. 2015 Jan;74:23-31. PMID: 25314142
Postnatal weight growth and trihalomethane exposure during pregnancy
Botton J, Kogevinas M, Gracia-Lavedan E, Patelarou E, Roumeliotaki T, Iñiguez C, Santa Marina L, Ibarluzea J, Ballester F, Mendez MA, Chatzi L, Sunyer J, Villanueva CM. Postnatal weight growth and trihalomethane exposure during pregnancy. Environ Res. 2015 Jan;136:280-8. PMID: 25460647
Folic Acid supplements during pregnancy and child psychomotor development after the first year of life
Valera-Gran D, García de la Hera M, Navarrete-Muñoz EM, Fernandez-Somoano A, Tardón A, Julvez J, Forns J, Lertxundi N, Ibarluzea JM, Murcia M, Rebagliato M, Vioque J; Infancia y Medio Ambiente (INMA) Project. Folic Acid supplements during pregnancy and child psychomotor development after the first year of life. JAMA Pediatr. 2014 Nov 3;168(11):e142611. doi:10.1001/jamapediatrics.2014.2611. Epub 2014 Nov 3. PMID: 25365251
In utero exposure to mixtures of xenoestrogens and child neuropsychological development
Vilahur N, Fernández MF, Bustamante M, Ramos R, Forns J, Ballester F, Murcia M, Riaño I, Ibarluzea J, Olea N, Sunyer J. In utero exposure to mixtures of xenoestrogens and child neuropsychological development. Environ Res. 2014 Jul 31;134C:98-104. PMID: 25086706
Family context assessment in a public health study
Velasco D, Sánchez de Miguel M, Egurza M, Arranz E, Aranbarri A, Fano E, Ibarluzea J. Family context assessment in a public health study. Gac Sanit. 2014 Sep-Oct;28(5):356-62. PMID: 24929614
Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta
Vilahur N, Bustamante M, Byun HM, Fernandez MF, Santa Marina L, Basterrechea M, Ballester F, Murcia M, Tardón A, Fernández-Somoano A, Estivill X, Olea N, Sunyer J, Baccarelli AA. Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta. Environ Int.2014 Jun 27;71C:81-87. PMID: 24980756
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Kl. Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts.E pidemiology. 2014 Sep;25(5):636-647. PMID: 25036432
The human early-life exposome (HELIX): project rationale and design
Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražul. The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect. 2014 Jun;122(6):535-44. PMID: 24610234
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