Prenatal Exposure to Multiple Air Pollutants, Mediating Molecular Mechanisms, and Shifts in Birthweight

Laine JE, Bodinier B, Robinson O, Plusquin M, Scalbert A, Keski-Rahkonen P, Robinot N, Vermeulen R, Pizzi C, Asta F, Nawrot T, Gulliver J, Chatzi L, Kogevinas M, Nieuwenhuijsen M, Sunyer J, Vrijheid M, Chadeau-Hyam M, Vineis P. Prenatal Exposure to Multiple Air Pollutants, Mediating Molecular Mechanisms, and Shifts in Birthweight. Environ Sci Technol. 2020 Nov 17;54(22):14502-14513. doi: 10.1021/acs.est.0c02657. Epub 2020 Oct 30. PMID: 33124810

The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project

Compañ Gabucio LM, García de la Hera M, Torres Collado L, Fernández-Somoano A, Tardón A, Guxens M, Vrijheid M, Rebagliato M, Murcia M, Ibarluzea J, Martí I, Vioque J. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project. Nutrients. 2021 Jan 23;13(2):327. PMID: 33498619

Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts

Jedynak P, Maitre L, Guxens M, Gützkow KB, Julvez J, López-Vicente M, Sunyer J, Casas M, Chatzi L, Gražulevičienė R, Kampouri M, McEachan R, Mon-Williams M, Tamayo I, Thomsen C, Urquiza J, Vafeiadi M, Wright J, Basagaña X, Vrijheid M, Philippat C. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts. Sci Total Environ. 2021 Apr 1;763:144115. PMID: 33422710

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM 2.5 exposure

Merid SK, Bustamante M, Standl M, Sunyer J, Heinrich J, Lemonnier N, Aguilar D, Antó JM, Bousquet J, Santa-Marina L, Lertxundi A, Bergström A, Kull I, Wheelock ÅM, Koppelman GH, Melén E, Gruzieva O. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM 2.5 exposure. Environ Int. 2021 Jan;146:106248.
PMID: 33212358

Shared DNA methylation signatures in childhood allergy: The MeDALL study

Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G; BIOS Consortium, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021 Mar;147(3):1031-1040. PMID: 33338541

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, Heiskala A, Horikoshi M, Fedko IO, Vilor-Tejedor N, Cousminer DL, Standl M, Wang CA, Viikari J, Geller F, Íñiguez C, Pitkänen N, Chesi A, Bacelis J, Yengo L, Torrent M, Ntalla I, Helgeland Ø, Selzam S, Vonk JM, Zafarmand MH, Heude B, Farooqi IS, Alyass A, Beaumont RN, Have CT, Rzehak P, Bilbao JR, Schnurr TM, Barroso I, Bønnelykke K, Beilin LJ, Carstensen L, Charles MA, Chawes B, Clément K, Closa-Monasterolo R, Custovic A, Eriksson JG, Escribano J, Groen-Blokhuis M, Grote V, Gruszfeld D, Hakonarson H, Hansen T, Hattersley AT, Hollensted M, Hottenga JJ, Hyppönen E, Johansson S, Joro R, Kähönen M, Karhunen V, Kiess W, Knight BA, Koletzko B, Kühnapfel A, Landgraf K, Langhendries JP, Lehtimäki T, Leinonen JT, Li A, Lindi V, Lowry E, Bustamante M, Medina-Gomez C, Melbye M, Michaelsen KF, Morgen CS, Mori TA, Nielsen TRH, Niinikoski H, Oldehinkel AJ, Pahkala K, Panoutsopoulou K, Pedersen O, Pennell CE, Power C, Reijneveld SA, Rivadeneira F, Simpson A, Sly PD, Stokholm J, Teo KK, Thiering E, Timpson NJ, Uitterlinden AG, van Beijsterveldt CEM, van Schaik BDC, Vaudel M, Verduci E, Vinding RK, Vogel M, Zeggini E, Sebert S, Lind MV, Brown CD, Santa-Marina L, Reischl E, Frithioff-Bøjsøe C, Meyre D, Wheeler E, Ong K, Nohr EA, Vrijkotte TGM, Koppelman GH, Plomin R, Njølstad PR, Dedoussis GD, Froguel P, Sørensen TIA, Jacobsson B, Freathy RM, Zemel BS, Raitakari O, Vrijheid M, Feenstra B, Lyytikäinen LP, Snieder H, Kirsten H, Holt PG, Heinrich J, Widén E, Sunyer J, Boomsma DI, Järvelin MR, Körner A, Davey Smith G, Holm JC, Atalay M, Murray C, Bisgaard H, McCarthy MI; Early Growth Genetics Consortium, Jaddoe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020 Oct 12;16(10):e1008718. PMID: 33045005

Urban environment during early-life and blood pressure in young children

Warembourg C, Nieuwenhuijsen M, Ballester F, de Castro M, Chatzi L, Esplugues A, Heude B, Maitre L, McEachan R, Robinson O, Slama R, Sunyer J, Urquiza J, Wright J, Basagaña X, Vrijheid M. Urban environment during early-life and blood pressure in young children. Environ Int. 2021 Jan;146:106174. PMID: 33099063.

Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Santa-Marina L, Lertxundi N, Andiarena A, Irizar A, Sunyer J, Molinuevo A, Llop S, Julvez J, Beneito A, Ibarluzea J, Imaz L, Ferrin M. Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study. Int J Environ Res Public Health. 2020 Oct 22;17(21):7704. PMID: 33105572.

Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index

Cadiou S, Bustamante M, Agier L, Andrusaityte S, Basagaña X, Carracedo A, Chatzi L, Grazuleviciene R, Gonzalez JR, Gutzkow KB, Maitre L, Mason D, Millot F, Nieuwenhuijsen M, Papadopoulou E, Santorelli G, Saulnier PJ, Vives M, Wright J, Vrijheid M, Slama R. Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index. Environ Int. 2020 May;138:105622. PMID: 32179316.

In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children

Vives-Usano M, Hernandez-Ferrer C, Maitre L, Ruiz-Arenas C, Andrusaityte S, Borràs E, Carracedo Á, Casas M, Chatzi L, Coen M, Estivill X, González JR, Grazuleviciene R, Gutzkow KB, Keun HC, Lau CE, Cadiou S, Lepeule J, Mason D, Quintela I, Robinson O, Sabidó E, Santorelli G, Schwarze PE, Siskos AP, Slama R, Vafeiadi M, Martí E, Vrijheid M, Bustamante M. In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children. BMC Med. 2020 Aug 19;18(1):243. PMID: 32811491.

Association between the pregnancy exposome and fetal growth

Agier L, Basagaña X, Hernandez-Ferrer C, Maitre L, Tamayo Uria I, Urquiza J, Andrusaityte S, Casas M, de Castro M, Cequier E, Chatzi L, Donaire-Gonzalez D, Giorgis-Allemand L, Gonzalez JR, Grazuleviciene R, Gützkow KB, Haug LS, Sakhi AK, McEachan RRC, Meltzer HM, Nieuwenhuijsen M, Robinson O, Roumeliotaki T, Sunyer J, Thomsen C, Vafeiadi M, Valentin A, West J, Wright J, Siroux V, Vrijheid M, Slama R. Association between the pregnancy exposome and fetal growth. Int J Epidemiol. 2020 Apr 1;49(2):572-586. PMID: 32167557.

A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

Lemonnier N, Melén E, Jiang Y, Joly S, Ménard C, Aguilar D, Acosta-Perez E, Bergström A, Boutaoui N, Bustamante M, Canino G, Forno E, Ramon González J, Garcia-Aymerich J, Gruzieva O, Guerra S, Heinrich J, Kull I, Ibarluzea Maurolagoitia J, Santa-Marina Rodriguez L, Thiering E, Wickman M, Akdis C, Akdis M, Chen W, Keil T, Koppelman GH, Siroux V, Xu CJ, Hainaut P, Standl M, Sunyer J, Celedón JC, Maria Antó J, Bousquet J. A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents. Allergy. 2020 Dec;75(12):3248-3260. PMID: 32277847