Granada
2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.
Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.
Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.
Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.
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Entidades Colaboradoras:
Buscador
Association of traffic-related air pollution with cognitive development in children
Freire C, Ramos R, Puertas R, Lopez-Espinosa MJ, Julvez J, Aguilera I, Cruz F, Fernandez MF, Sunyer J, Olea N. Association of traffic-related air pollution with cognitive development in children. J Epidemiol Community Health. 2010 Mar;64(3):223-8. PMID: 19679705
Prenatal exposure to mirex impairs neurodevelopment at age of 4 years
Puertas R, Lopez-Espinosa MJ, Cruz F, Ramos R, Freire C, Pérez-García M, Abril A, Julvez J, Salvatierra M, Campoy C, Olea N. Prenatal exposure to mirex impairs neurodevelopment at age of 4 years. Neurotoxicology. 2010 Jan;31(1):154-160. PMID: 19818364
Hair mercury levels, fish consumption, and cognitive development in preschool children from Granada, Spain
Freire C, Ramos R, Lopez-Espinosa MJ, Díez S, Vioque J, Ballester F, Fernández MF. Hair mercury levels, fish consumption, and cognitive development in preschool children from Granada, Spain. Environ Res. 2010 Jan;110(1):96-104. PMID: 19909946
Assessment of the total effective xenoestrogen burden in extracts of human placentas
Lopez-Espinosa MJ, Silva E, Granada A, Molina-Molina JM, Fernandez MF, Aguilar-Garduño C, Olea-Serrano F, Kortenkamp A, Olea N. Evaluación de la carga total de xenoestrógeno eficaz en los extractos de placenta humana. Biomarkers. 2009;14(5):271-7. PMID: 19476411
Urinary 1-hydroxypyrene and PAH exposure in 4-year-old Spanish children
Freire C, Abril A, Fernández MF, Ramos R, Estarlich M, Manrique A, Aguirre A, Ibarluzea J, Olea N. Urinary 1-hydroxypyrene and PAH exposure in 4-year-old Spanish children. Sci Total Environ. 2009 15;407(5):1562-9. Epub 2008 Dec 17. PMID: 19095289
The total effective xenoestrogen burden, a biomarker of exposure to xenoestrogen mixtures, is predicted by the (anti)estrogenicity of its components
Fernandez MF, Aguilar-Garduño C, Molina-Molina JM, Arrebola JP, Olea N. The total effective xenoestrogen burden, a biomarker of exposure to xenoestrogen mixtures, is predicted by the (anti)estrogenicity of its components. Reprod Toxicol. 2008;26(1):8-12. Epub 2008 Jun 8. PMID: 18586082
Trihalomethane levels in drinking water in the province of Granada (Spain).
Freire C, Soler R, Fernández MF, Villanueva CM, Grimalt JO, Olea N. Trihalomethane levels in drinking water in the province of Granada [Spain]. Gac Sanit. 2008;22(6):520-6. Spanish. PMID: 19080927
Predicción del desarrollo mental a los 20 meses de edad por medio de la evaluación del desarrollo psicomotor a los seis meses de vida en niños sanos
Rosa Ramos, Francisco Cruz, Miguel Pérez, Ma. Teresa Salvatierra, Concepción Robles, Bertold U.V. Koletzko, Tamas Decsi, Cristina Campoy. Predicción del desarrollo mental a los 20 meses de edad por medio de la evaluación del desarrollo psicomotor a los seis meses de vida en niños sanos. Salud Mental. 2008;31(1):53-61.
The Spanish Environment and Childhood Research Network (INMA study)
Fernandez MF, Sunyer J, Grimalt J, Rebagliato M, Ballester F, Ibarluzea J, Ribas-Fitó N, Tardon A, Fernandez-Patier R, Torrent M, Olea N. The Spanish Environment and Childhood Research Network (INMA study). Int J Hyg Environ Health. 2007;210(3-4):491-3. Epub 2007 Feb 22. PMID: 17320477
Air pollutant exposure during pregnancy and fetal and early childhood development. Research protocol of the INMA (Childhood and Environment Project)
Esplugues A, Fernández-Patier R, Aguilera I, Iñíguez C, García Dos Santos S, Aguirre Alfaro A, Lacasaña M, Estarlich M, Grimalt JO, Fernández M, Rebagliato M, Sala M, Tardón A, Torrent M, Martínez MD, Ribas-Fitó N, Sunyer J, Ballester F. Air pollutant exposure during pregnancy and fetal and early childhood development. Research protocol of the INMA (Childhood and Environment Project). Gac Sanit. 2007;21(2):162-71. Spanish. PMID: 17419934
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