Granada
2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.
Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.
Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.
Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.
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Entidades Colaboradoras:
Buscador
Exposure to Trihalomethanes through Different Water Uses and Birth Weight, Small for Gestational Age and Preterm Delivery in Spain
Villanueva CM, Gracia-Lavedan E, Ibarluzea J, Santa Marina L, Ballester F, Llop S, Tardón A, Fernandez MF, Freire C, Goñi F, Basagaña X, Kogevinas M, Grimalt JO, Sunyer J; INMA project. Exposure to Trihalomethanes through Different Water Uses and Birth Weight, Small for Gestational Age and Preterm Delivery in Spain. Environ Health Perspect. 2011 Dec;119(12):1824-30. PMID: 21810554
Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry
Vela-Soria F, Jiménez-Díaz I, Rodríguez-Gómez R, Zafra-Gómez A, Ballesteros O, Navalón A, Vílchez JL, Fernández MF, Olea N. Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry. Talanta. 2011 Sep 30;85(4):1848-55. PMID: 21872029
Prenatal exposure to organochlorine pesticides and TSH status in newborns from Southern Spain
Freire C, Lopez-Espinosa MJ, Fernández M, Molina-Molina JM, Prada R, Olea N. Prenatal exposure to organochlorine pesticides and TSH status in newborns from Southern Spain. Sci Total Environ. 2011 Aug 15;409(18):3281-7. PMID: 21683986
Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children
Casas L, Fernández MF, Llop S, Guxens M, Ballester F, Olea N, Irurzun MB, Rodríguez LS, Riaño I, Tardón A, Vrijheid M, Calafat AM, Sunyer J; On behalf of the INMA Project. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ Int. 2011 Jul;37(5):858-66. PMID: 21429861
A new liquid chromatography-tandem mass spectrometry method for determination of parabens in human placental tissue samples
Jiménez-Díaz I, Vela-Soria F, Zafra-Gómez A, Navalón A, Ballesteros O, Navea N, Fernández MF, Olea N, Vílchez JL. A new liquid chromatography-tandem mass spectrometry method for determination of parabens in human placental tissue samples. Talanta. 2011 May 15;84(3):702-9. PMID: 21482271
Relationship between occupational social class and exposure to organochlorine pesticides during pregnancy
Freire C, Amaya E, Fernández MF, González-Galarzo MC, Ramos R, Molina-Molina JM, Arrebola JP, Olea N. Relationship between occupational social class and exposure to organochlorine pesticides during pregnancy. Chemosphere. 2011 Apr;83(6):831-8. PMID: 21435678
Determination of Bisphenol A and its chlorinated derivatives in placental tissue samples by liquid chromatography-tandem mass spectrometry
Jiménez-Díaz I, Zafra-Gómez A, Ballesteros O, Navea N, Navalón A, Fernández MF, Olea N, Vílchez JL. Determination of Bisphenol A and its chlorinated derivatives in placental tissue samples by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 15;878(32):3363-9. PMID: 21093390
Trihalomethanes in swimming pool water in four areas of Spain participating in the INMA project
Font-Ribera L, Esplugues A, Ballester F, Martínez-Argüelles B, Tardón A, Freire C, Fernández MF, Carrasco G, Cases A, Sunyer J, Villanueva CM. Trihalomethanes in swimming pool water in four areas of Spain participating in the INMA project. Gac Sanit. 2010 November – December;24(6):483-486. PMID: 21074293
Newborn TSH concentration and its association with cognitive development in healthy boys
Freire C, Ramos R, Amaya E, Fernández MF, Santiago-Fernández P, Lopez-Espinosa MJ, Arrebola JP, Olea N. Newborn TSH concentration and its association with cognitive development in healthy boys. Eur J Endocrinol. 2010 Dec;163(6):901-9.PMID: 20829366
Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet
Mariscal-Arcas M, Lopez-Martinez C, Granada A, Olea N, Lorenzo-Tovar ML, Olea-Serrano F. Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet. Food Chem Toxicol. 2010 May;48(5):1311-5. PMID: 20188779
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