Granada
En el año 2001 comenzó en el Hospital Clínico de Granada y el Hospital de Poniente de Almería el reclutamiento de una cohorte de mujeres embarazadas, con el objeto de estudiar la relevancia de malformaciones del tracto genito-urinario masculino en los recién nacidos.
El objetivo era intentar demostrar la existencia de una relación entre la exposición crónica de la madre a compuestos químicos ambientales con actividad hormonal, “disruptores endocrinos” y la frecuencia de criptorquidia e hipospadias en la descendencia.
Con este motivo se reclutaron aproximadamente 700 mujeres que dieron a luz hijos varones, entre los que se detectaron más de 50 casos indexados (criptorquidia y/o hipospadias). Paralelamente se inició un estudio caso-control de 150 recién nacidos con intervención en la dieta durante el embarazo (suplemento de ácido fólico a las madres).
La cohorte de madres-hijos y nacimientos está proporcionando información muy útil sobre la exposición materno-infantil a compuestos químicos con actividad hormonal. Los estudios que ya se han iniciado han servido para poner de manifiesto la importancia de la exposición materna y las diferencias regionales existentes con otros países europeos. La aplicación adicional de marcadores de exposición está siendo de utilidad en la caracterización de las interacciones entre compuestos químicos y el efecto hormonal resultante.
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Entidades Colaboradoras:
Buscador
Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis
Synergy for the Influence of the Month of Birth in ADHD (SIMBA) study group. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. Lancet Psychiatry. 2023 Dec;10(12):922-933. PMID: 37898142
Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women
Bláhová L, Janoš T, Mustieles V, Rodríguez-Carrillo A, Fernández MF, Bláha L. Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women. Int J Hyg Environ Health. 2023 May;250:114175. PMID: 37105016
Xeno-estrogenic activity of real-life mixtures of perfluoroalkylated substances in human placenta homogenates
Wielsøe M, Molina-Molina JM, Rodríguez-Carrillo A, Mustieles V, Olea N, Fernandez MF, Bonefeld-Jørgensen EC. Xeno-estrogenic activity of real-life mixtures of perfluoroalkylated substances in human placenta homogenates. Reprod Toxicol. 2023 Sep;120:108444. PMID: 37473930
Development and validation of brain-derived neurotrophic factor measurement in human urine samples as a non-invasive effect biomarker
Olivas-Martinez A, Suarez B, Salamanca-Fernandez E, Reina-Perez I, Rodriguez-Carrillo A, Mustieles V, Olea N, Freire C, Fernández MF. Development and validation of brain-derived neurotrophic factor measurement in human urine samples as a non-invasive effect biomarker. Front Mol Neurosci. 2023 Jan 12;15:1075613. PMID: 36710936
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge
Rodríguez-Carrillo A, Mustieles V, Salamanca-Fernández E, Olivas-Martínez A, Suárez B, Bajard L, Baken K, Blaha L, Bonefeld-Jørgensen EC, Couderq S, D’Cruz SC, Fini JB, Govarts E, Gundacker C, Hernández AF, Lacasaña M, Laguzzi F, Linderman B, Long M, Louro H, Neophytou C, Oberemn A, Remy S, Rosenmai AK, Saber AT, Schoeters G, Silva MJ, Smagulova F, Uhl M, Vinggaard AM, Vogel U, Wielsøe M, Olea N, Fernández MF. Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge. Int J Hyg Environ Health. 2023 Apr;249:114140. PMID: 36841007
Exposure to non-persistent pesticides and sexual maturation of Spanish adolescent males
Castiello F, Suárez B, Gómez-Vida J, Torrent M, Fernández MF, Olea N, Freire C. Exposure to non-persistent pesticides and sexual maturation of Spanish adolescent males. Chemosphere. 2023 May;324:138350. PMID: 36907483.
Exposure to perfluoroalkyl substances (PFAS) and association with thyroid hormones in adolescent males
Freire C, Vela-Soria F, Castiello F, Salamanca-Fernández E, Quesada-Jiménez R, López-Alados MC, Fernández M, Olea N. Exposure to perfluoroalkyl substances (PFAS) and association with thyroid hormones in adolescent males. Int J Hyg Environ Health. 2023 Jul:252:114219. PMID: 37451108
Kisspeptin as potential biomarker of environmental chemical mixture effect on reproductive hormone profile: A pilot study in adolescent males
Rodriguez-Carrillo A, Remy S, D’Cruz SC, Salamanca-Fernandez E, Gil F, Olmedo P, Mustieles V, Vela-Soria F, Baken K, Olea N, Smagulova F, Fernandez MF, Freire C. Kisspeptin as potential biomarker of environmental chemical mixture effect on reproductive hormone profile: A pilot study in adolescent males. Sci Total Environ. 2023 Apr 10;868:161668. PMID: 36657687
Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort
Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C. Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort. Environ Pollut. 2023 Jan 1;316(Pt 2):120571. PMID: 36356884
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data
D’Cruz SC, Hao C, Labussiere M, Mustieles V, Freire C, Legoff L, Magnaghi-Jaulin L, Olivas-Martinez A, Rodriguez-Carrillo A, Jaulin C, David A, Fernandez MF, Smagulova F. Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data. Clin Epigenetics. 2022 Dec 26;14(1):186. PMID: 36572933
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