Granada
2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.
Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.
Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.
Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.
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Entidades Colaboradoras:
Buscador
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražuleviien R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen A. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environ Health Perspect. 2016 Nov;124(11):1785-1793. PMID: 27152464
La biomonitorización de sustancias tóxicas en muestras biológicas de población general
Ibarluzea J, Aurrekoetxea JJ, Porta M, Sunyer J, Ballester F. La biomonitorización de sustancias tóxicas en muestras biológicas de población general. Gac Sanit. 2016 Nov;30 Suppl 1:45-54.PMID: 27132480
Second-hand smoke exposure in 4-year-old children in Spain: Sources, associated factors and urinary cotinine
Aurrekoetxea JJ, Murcia M, Rebagliato M, Guxens M, Fernández-Somoano A, López MJ, Lertxundi A, Castilla AM, Espada M, Tardón A, Ballester F, Santa-Marina L. Second-hand smoke exposure in 4-year-old children in Spain: Sources, associated factors and urinary cotinine. Environ Res. 2016 Feb;145:116-25. PMID: 26656512
Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta
Vilahur N, Bustamante M, Morales E, Motta V, Fernandez MF, Salas LA, Escaramis G, Ballester F, Murcia M, Tardon A, Riaño I, Santa-Marina L, Ibarluzea J, Arrebola JP, Estivill X, Bollati V, Sunyer J, Olea N. Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta. Epigenomics.2016 Jan;8(1):43-54. PMID: 26679211
Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias
Fernández MF, Arrebola JP, Jiménez-Díaz I, Sáenz JM, Molina-Molina JM, Ballesteros O, Kortenkamp A, Olea N. Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias. Reprod Toxicol. 2016 Jan;59:89-95. PMID: 26602963
Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol
Gallastegi M, Guxens M, Jiménez-Zabala A, Calvente I, Fernández M, Birks L, Struchen B, Vrijheid M, Estarlich M, Fernández MF, Torrent M, Ballester F, Aurrekoetxea JJ, Ibarluzea J, Guerra D, González J, Röösli M, Santa-Marina L. Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol. BMC Public Health. 2016 Feb 18;16(1):167. PMID: 26892951
Does exposure to environmental radiofrequency electromagnetic fields cause cognitive and behavioral effects in 10-year-old boys?
Irene Calvente, Rocío Pérez-Lobato, María-Isabel Núñez, Rosa Ramos1, Mònica Guxens, Juan Villalba, Nicolás Oleaand Mariana F. Fernández. Does exposure to environmental radiofrequency electromagnetic fields cause cognitive and behavioral effects in 10-year-old boys?. Bioelectromagnetics. 2016 January Volume 37, Issue 1, pages 25–36.
Exploring educational disparities in risk of preterm delivery: a comparative study of 12 European birth cohorts
Poulsen G, Strandberg-Larsen K, Mortensen L, Barros H, Cordier S, Correia S, Danileviciute A, van Eijsden M, Fernández-Somoano A, Gehring U, Grazuleviciene R, Hafkamp-de Groen E, Henriksen TB, Jensen MS, Larrañaga I, Magnus P, Pickett K, Raat H, Rich. Exploring educational disparities in risk of preterm delivery: a comparative study of 12 European birth cohorts. Paediatr Perinat Epidemiol. 2015 May;29(3):172-83. PMID: 25808200
Trends in children’s exposure to second-hand smoke in the INMA-Granada cohort: an evaluation of the Spanish anti-smoking law
Fernández MF, Artacho-Cordón F, Freire C, Pérez-Lobato R, Calvente I, Ramos R, Castilla AM, Ocón O, Dávila C, Arrebola JP, Olea N. Trends in children’s exposure to second-hand smoke in the INMA-Granada cohort: an evaluation of the Spanish anti-smoking law. Environ Res. 2015 Apr;138:461-8. PMID: 25794848
Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
Casas M, Cordier S, Martínez D, Barros H, Bonde JP, Burdorf A, Costet N, Dos Santos AC, Danileviciute A, Eggesbø M, Fernandez M, Fevotte J, García AM, Gražuleviciene R, Hallner E, Hanke W, Kogevinas M, Kull I, Stemann Larsen P, Melaki V, Monfort C, N. Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts. Scand J Work Environ Health. 2015 Jul 1;41(4):384-396 PMID: 25940455
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