Granada
2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.
Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.
Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.
Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.
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Entidades Colaboradoras:
Buscador
Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
Casas M, Cordier S, Martínez D, Barros H, Bonde JP, Burdorf A, Costet N, Dos Santos AC, Danileviciute A, Eggesbø M, Fernandez M, Fevotte J, García AM, Gražuleviciene R, Hallner E, Hanke W, Kogevinas M, Kull I, Stemann Larsen P, Melaki V, Monfort C, N. Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts. Scand J Work Environ Health. 2015 Jul 1;41(4):384-396 PMID: 25940455
Outdoor characterization of radio frequency electromagnetic fields in a Spanish birth cohort
Calvente I, Fernández MF, Pérez-Lobato R, Dávila-Arias C, Ocón O, Ramos R, Ríos-Arrabal S, Villalba-Moreno J, Olea N, Núñez MI. Outdoor characterization of radio frequency electromagnetic fields in a Spanish birth cohort. Environ Res. .2015 Feb 20;138C:136-143. PMID: 25707018
Thyroid status and its association with cognitive functioning in healthy boys at 10 years of age
Perez-Lobato R, Ramos R, Arrebola JP, Calvente I, Ocon-Hernandez O, Dávila-Arias C, Pérez-Garcia M, Olea N, Fernández MF. Thyroid status and its association with cognitive functioning in healthy boys at 10 years of age. Eur J Endocrinol. 2015 Feb;172(2):129-39. PMID: 25394567
Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers
Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, Chatzi L, Chevrier C, Eggesbø M, Fernandez MF, Govarts E, Guxens M, Grimalt JO, Hertz-Picciotto I, Iszatt N, Kasper-Sonnenberg M, Kiviranta H, Kogevinas M, Palkovicova L,. Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers. Environ Int. 2015 Jan;74:23-31. PMID: 25314142
Characterization of indoor extremely low frequency and low frequency electromagnetic fields in the INMA-Granada cohort
Calvente I, Dávila-Arias C, Ocón-Hernández O, Pérez-Lobato R, Ramos R, Artacho-Cordón F, Olea N, Núñez MI, Fernández MF. Characterization of indoor extremely low frequency and low frequency electromagnetic fields in the INMA-Granada cohort. PLoS One. 2014 Sep 5;9(9):e106666. doi: 10.1371/journal.pone.0106666. eCollection 2014. PMID: 25192253
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Kl. Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts.E pidemiology. 2014 Sep;25(5):636-647. PMID: 25036432
Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes
Slama R, Ballester F, Casas M, Cordier S, Eggesbø M, Iniguez C, Nieuwenhuijsen M, Philippat C, Rey S, Vandentorren S, Vrijheid M. Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes. Epidemiol Rev. 2014;36(1):148-64. PMID: 24363355
Ambient air pollution and low birthweight: a European cohort study (ESCAPE)
Pedersen M, Giorgis-Allemand L, Bernard C, Aguilera I, Andersen AM, Ballester F, Beelen RM, Chatzi L, Cirach M, Danileviciute A, Dedele A, Eijsden Mv, Estarlich M, Fernández-Somoano A, Fernández MF, Forastiere F, Gehring U, Grazuleviciene R, Gruzieva. Ambient air pollution and low birthweight: a European cohort study (ESCAPE). Lancet Respir Med. 2013 Nov;1(9):695-704. PMID: 24429273
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity
Jiménez-Díaz I, Molina-Molina JM, Zafra-Gómez A, Ballesteros O, Navalón A, Real M, Sáenz JM, Fernández MF, Olea N. Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine a. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 1;936:80-7. PMID: 24004914
Socio-Economic Inequalities in Health, Habits and Self-Care During Pregnancy in Spain
Larrañaga I, Santa-Marina L, Begiristain H, Machón M, Vrijheid M, Casas M, Tardón A, Fernández-Somoano A, Llop S, Rodriguez-Bernal CL, Fernandez MF. Socio-Economic Inequalities in Health, Habits and Self-Care During Pregnancy in Spain. Matern Child Health J. 2013 Sep;17(7):1315-24. PMID: 22983810
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