Granada
2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.
Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.
Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.
Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.
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Entidades Colaboradoras:
Buscador
Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe
Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, Gong T, Gehring U, Sørensen M, Standl M, Sugiri D, Almqvist C, Andiarena A, Badaloní C, Beelen R, Berdel D, Cesaroni G, Charles MA, Eriksen KT, Estarlich M, Fernandez MF, Forhan A, Jaddoe VWV, Korek M, Lichtenstein P, Lertxundi A, Lopez-Espinosa MJ, Markevych I, de Nazelle A, Raaschou-Nielsen O, Nieuwenhuijsen M, Pérez-Lobato R, Philippat C, Slama R, Tiesler CM, Verhulst FC, von Berg A, Vrijkotte T, Nybo Andersen AM, Heude B, Krämer U, Heinrich J, Tiemeier H, Forastiere F, Pershagen G, Brunekreef B, Guxens M. Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe. Epidemiology. 2018 Sep;29(5):618-626. PMID: 29923866
Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?
Eeftens M, Struchen B, Birks LE, Cardis E, Estarlich M, Fernandez MF, Gajšek P, Gallastegi M, Huss A, Kheifets L, Meder IK, Olsen J, Torrent M, Trček T, Valič B, Vermeulen R, Vrijheid M, van Wel L, Guxens M, Röösli M. Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?. Environ Int. 2018 Dec;121(Pt 1):216-226. PMID: 30216774
Anogenital distance and reproductive outcomes in 9- to 11-year-old boys: the INMA-Granada cohort study
Freire C, Ocón-Hernández O, Dávila-Arias C, Pérez-Lobato R, Calvente I, Ramos R, Olea N, Fernández MF. Anogenital distance and reproductive outcomes in 9- to 11-year-old boys: the INMA-Granada cohort study. Andrology. 2018 Nov;6(6):874-881. PMID: 30113141
The INMA-INfancia y Medio Ambiente-(Environment and Childhood) project: More than 10 years contributing to environmental and neuropsychological research
Gascon M, Guxens M, Vrijheid M, Torrent M, Ibarluzea J, Fano E, Llop S, Ballester F, Fernández MF, Tardón A, Fernández-Somoano A, Sunyer J. The INMA-INfancia y Medio Ambiente-(Environment and Childhood) project: More than 10 years contributing to environmental and neuropsychological research. Int J Hyg Environ Health. 2017 Jun;220(4):647-658. PMID: 28291591
The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth
Giorgis-Allemand L, Pedersen M, Bernard C, Aguilera I, Beelen RM, Chatzi L, Cirach M, Danileviciute A, Dedele A, van Eijsden M, Estarlich M, Fernández-Somoano A, Fernández MF, Forastiere F, Gehring U, Grazuleviciene R, Gruzieva O, Heude B, Hoek G, de. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth. Am J Epidemiol. 2017 Feb 15;185(4):247-258. PMID: 28087514
Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies
Ballesteros V, Costa O, Iñiguez C, Fletcher T, Ballester F, Lopez-Espinosa MJ. Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies. Environ Int. 2017 Feb;99:15-28. PMID: 27884404
Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry
Vela-Soria F, Gallardo-Torres ME, Ballesteros O, Díaz C, Pérez J, Navalón A, Fernández MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2017 Mar 3;1487:153-161. PMID: 28129936
Determination of endocrine-disrupting chemicals in human milk by dispersive liquid-liquid microextraction
Vela-Soria F, Jiménez-Díaz I, Díaz C, Pérez J, Iribarne-Durán LM, Serrano-López L, Arrebola JP, Fernández MF, Olea N. Determination of endocrine-disrupting chemicals in human milk by dispersive liquid-liquid microextraction. Bioanalysis. 2016 Sep;8(17):1777-91. PMID: 27523983
Exposure to bisphenol A and behavior in school-age children
Perez-Lobato R, Mustieles V, Calvente I, Jimenez-Diaz I, Ramos R, Caballero-Casero N, López-Jiménez FJ, Rubio S, Olea N, Fernandez MF. Exposure to bisphenol A and behavior in school-age children. Neurotoxicology. 2016 Mar;53:12-19. PMID: 26654821
Environment and Brain Development: Challenges in the Global Context
Júlvez J, Paus T, Bellinger D, Eskenazi B, Tiemeier H, Pearce N, Ritz B, White T, Ramchandani P, Gispert JD, Desrivières S, Brouwer R, Boucher O, Alemany S, López-Vicente M, Suades-González E, Forns J, Grandjean P, Sunyer J. Environment and Brain Development: Challenges in the Global Context. Neuroepidemiology. 2016;46(2):79-82. PMID: 26684467
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