Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children
Whitworth KW, Lertxundi A, Yuan M, Rector-Houze A, Chen WJ, Guxens M, Julvez J, Swartz M, Symanski E, Valentin A, Iniguez C, González-Safont LL, Ibarluzea J. Early life exposure to fine particulate matter and fine motor function, attentional function, and working memory among Spanish school-aged children. Environ Epidemiol. 2025 May 14;9(3):e396. PMID: 40375972
Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study
Pinar-Martí A, Ayala-Aldana N, Ruiz-Rivera M, Lertxundi N, Subiza-Pérez M, González-Safont L, Vioque J, Riaño-Galán I, Rodríguez-Dehli C, Iglesias-Vázquez L, Arija V, Fernández-Barrés S, Romaguera D, Pascual-Rubio V, Fabregat-Sanjuan A, Healy D, Basagaña X, Vrijheid M, Guxens M, Foraster M, Julvez J. Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study. Am J Clin Nutr. 2025 Jul;122(1):274-284. PMID: 40334748.
Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative
Valencia-Hernández CA, Yu Z, Gehring U, Koppelman GH, Standl M, Flexeder C, Schikowski T, Kress S, Melén E, Gruzieva O, Lõhmus M, Faner R, Agusti A, Wedzicha JA, Garcia-Aymerich J, Koch S, Nieuwenhuijsen M, Lertxundi A, Esplugues A, Ballester F, Arregi A, Markevych I, Bloom CI, Fuertes E; CADSET Clinical Research Collaboration. Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative. Environ Int. 2025 May;199:109493. PMID: 40311232
Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts
Warkentin S, Fossati S, Marquez S, Andersen AN, Andrusaityte S, Avraam D, Ballester F, Cadman T, Casas M, de Castro M, Chatzi L, Elhakeem A, d’Errico A, Guxens M, Grazuleviciene R, Harris JR, Hernandez CI, Heude B, Isaevska E, Jaddoe VWV, Karachaliou M, Lertxundi A, Lepeule J, McEachan RRC, Thorbjørnsrud Nader JL, Pedersen M, Santos S, Slofstra M, Stephanou EG, Swertz MA, Vrijkotte T, Yang TC, Nieuwenhuijsen M, Vrijheid M. Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts. Environ Int. 2025 Jun;200:109527. PMID: 40378473
Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology
Mulder TA, Guxens M, Rebagliato ML, Dineva M, Bath SC, Hunziker S, Sunyer J, Delgado-Saborit JM, Irizar Loibide A, Lertxundi N, Muetzel RL, Tiemeier H, Peeters RP, Korevaar TIM. Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology. J Clin Endocrinol Metab. 2025 Jun 17;110(7):2007-2015. PMID: 39329345
General population-based lung function trajectories over the life course: an accelerated cohort study
Garcia-Aymerich J, de Las Heras M, Carsin AE, Accordini S, Agustí A, Bui D, Dharmage SC, Dodd JW, Eze I, Gehring U, Gislason T, Granell R, Imboden M, Íñiguez C, Jeong A, Koch S, Koppelman GH, Leynaert B, Melén E, Perret J, Probst-Hensch N, Santa-Marina L, Torrent M, Vicendese D, Vonk JM, de Vries M, Walters EH, Wang G, Wedzicha JA, Jarvis D, Faner R. General population-based lung function trajectories over the life course: an accelerated cohort study. Lancet Respir Med. 2025 Jul;13(7):611-622. PMID: 40383131
Exposure to different types of residential greenness during pregnancy and early childhood and attention-deficit/hyperactivity disorder diagnosis: A nested case-control study
Luque-García L, García-Baquero G, Lertxundi A, Al-Delaimy WK, Yang TC, Delgado-Saborit JM, Guxens M, McEachan RRC, Vrijheid M, Estarlich M, Nieuwenhuijsen M, Ibarluzea J. Exposure to different types of residential greenness during pregnancy and early childhood and attention-deficit/hyperactivity disorder diagnosis: A nested case-control study. Sci Total Environ. 2025 Mar 15;969:178907. PMID: 39999706
Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference
Luque-García L, García-Baquero G, Lertxundi A, Al-Delaimy WK, Julvez J, Estarlich M, De Castro M, Guxens M, Lozano M, Subiza-Pérez M, Ibarluzea J. Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference. Int J Hyg Environ Health. 2025 Jan;263:114475. PMID: 39366079
Is maternal diabetes during pregnancy associated with neurodevelopmental, cognitive and behavioural outcomes in children? Insights from individual participant data meta-analysis in ten birth cohorts
Pretorius RA, Avraam D, Guxens M, Julvez J, Harris JR, Nader JT, Cadman T, Elhakeem A, Strandberg-Larsen K, Marroun HE, Defina S, Yang TC, McEachan R, Wright J, Ibarluzea J, Santa-Marina L, Delgado JM, Rebagliato M, Charles MA, Vainqueur C, Maritano S, Zugna D, Yuan WL, Heude B, Huang RC. Is maternal diabetes during pregnancy associated with neurodevelopmental, cognitive and behavioural outcomes in children? Insights from individual participant data meta-analysis in ten birth cohorts. BMC Pediatr. 2025 Jan 30;25(1):76. PMID: 39885386
Temperature Exposure and Psychiatric Symptoms in Adolescents From 2 European Birth Cohorts
Essers E, Kusters M, Granés L, Ballester J, Petricola S, Lertxundi N, Arregi A, Ballester F, Vrijheid M, El Marroun H, Iñiguez C, Tiemeier H, Guxens M. Temperature Exposure and Psychiatric Symptoms in Adolescents From 2 European Birth Cohorts. JAMA Netw Open. 2025 Jan 2;8(1):e2456898. PMID: 39874035
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