Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study
Petermann-Rocha F, Valera-Gran D, Prieto-Botella D, Martens DS, Gonzalez-Palacios S, Riaño-Galán I, Murcia M, Irizar A, Julvez J, Santa-Marina L, Tardón A, Sunyer J, Vioque J, Nawrot T, Navarrete-Muñoz EM. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study. Nutrients. 2023 Oct 9;15(19):4303. PMID: 37836587
Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index
Descarpentrie A, Calas L, Cornet M, Heude B, Charles MA, Avraam D, Brescianini S, Cadman T, Elhakeem A, Fernández-Barrés S, Harris JR, Inskip H, Julvez J, Llop S, Margetaki K, Maritano S, Nader JLT, Roumeliotaki T, Salika T, Subiza-Pérez M, Vafeiadi M, Vrijheid M, Wright J, Yang T, Dargent-Molina P, Lioret S. Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index. Pediatr Obes. 2023 Dec;18(12):e13079. PMID: 37795656
Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children
Soler-Blasco R, Llop S, Riutort-Mayol G, Lozano M, Vallejo-Ortega J, Murcia M, Ballester F, Irizar A, Andiarena A, Fernandez-Jimenez N, Braeuer S, Harari F. Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children. Environ Sci Technol. 2023 Oct 17;57(41):15366-15378. PMID: 37787746
A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles
Kiewiet MBG, Lupinek C, Vrtala S, Wieser S, Baar A, Kiss R, Kull I, Melén E, Wickman M, Porta D, Gori D, Gehring U, Aalberse R, Sunyer J, Standl M, Heinrich J, Waiblinger D, Wright J, Antó JM, Bousquet J, van Hage M, Valenta R. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles. Allergy. 2023 Jul;78(7):2007-2018. PMID: 36815272
Creatine Kinase Is Decreased in Childhood Asthma
Guerra S, Ledford JG, Melén E, Lavi I, Carsin AE, Stern DA, Zhai J, Vidal M, Bustamante M, Addison KJ, Vallecillo RG, Billheimer D, Koppelman GH, Garcia-Aymerich J, Lemonnier N, Fitó M, Dobaño C, Kebede Merid S, Kull I, McEachan RRC, Wright J, Chatzi L, Kogevinas M, Porta D, Narduzzi S, Ballester F, Esplugues A, Zabaleta C, Irizar A, Sunyer J, Halonen M, Bousquet J, Martinez FD, Anto JM. Creatine Kinase Is Decreased in Childhood Asthma. Am J Respir Crit Care Med. 2023 Mar 1;207(5):544-552. PMID: 35876143
Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
Rouxel E, Costet N, Monfort C, Audouze K, Cirugeda L, Gaudreau E, Grimalt JO, Ibarluzea J, Lainé F, Llop S, Lopez-Espinosa MJ, Rouget F, Santa-Marina L, Vrijheid M, Chevrier C, Casas M, Warembourg C. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents. Environ Int. 2023 Aug;178:108056. PMID: 37379720
Sleep duration in preschool age and later behavioral and cognitive outcomes: an individual participant data meta-analysis in five European cohorts
Guerlich K, Avraam D, Cadman T, Calas L, Charles MA, Elhakeem A, Fernández-Barrés S, Guxens M, Heude B, Ibarluzea J, Inskip H, Julvez J, Lawlor DA, Murcia M, Salika T, Sunyer J, Tafflet M, Koletzko B, Grote V, Plancoulaine S. Sleep duration in preschool age and later behavioral and cognitive outcomes: an individual participant data meta-analysis in five European cohorts. Eur Child Adolesc Psychiatry. 2024 Jan;33(1):167-177. PMID: 36749392
Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study
Florian S, Ichou M, Panico L, Pinel-Jacquemin S, Vrijkotte TGM, Harskamp-van Ginkel MW, Huang RC, Carson J, Rodriguez LSM, Subiza-Pérez M, Vrijheid M, Fernández-Barrés S, Yang TC, Wright J, Corpeleijn E, Cardol M, Isaevska E, Moccia C, Kooijman MN, Voerman E, Jaddoe V, Welten M, Spada E, Rebagliato M, Beneito A, Ronfani L, Charles MA. Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study. BMJ Open. 2023 Mar 23;13(3):e060932. PMID: 36958776
Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study
Cano-Sancho G, Warembourg C, Güil N, Stratakis N, Lertxundi A, Irizar A, Llop S, Lopez-Espinosa MJ, Basagaña X, González JR, Coumoul X, Fernández-Barrés S, Antignac JP, Vrijheid M, Casas M. Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study. Environ Health Perspect. 2023 Mar;131(3):37011. PMID: 36927187
PFAS levels and exposure determinants in sensitive population groups
Fábelová L, Beneito A, Casas M, Colles A, Dalsager L, Den Hond E, Dereumeaux C, Ferguson K, Gilles L, Govarts E, Irizar A, Lopez Espinosa MJ, Montazeri P, Morrens B, Patayová H, Rausová K, Richterová D, Rodriguez Martin L, Santa-Marina L, Schettgen T, Schoeters G, Haug LS, Uhl M, Villanger GD, Vrijheid M, Zaros C, Palkovičová Murínová Ľ. PFAS levels and exposure determinants in sensitive population groups. Chemosphere. 2023 Feb;313:137530. PMID: 36509187
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