Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
Morales E, Vilahur N, Salas LA, Motta V, Fernandez MF, Murcia M, Llop S, Tardon A, Fernandez-Tardon G, Santa-Marina L, Gallastegui M, Bollati V, Estivill X, Olea N, Sunyer J, Bustamante M. Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. Int J Epidemiol. 2016 Oct;45(5):1644-1655. PMID: 27591263
Drinking water disinfection by products, genetic polymorphisms, and birth outcomes in a European mother-child cohort study
Kogevinas M, Bustamante M, Gracia-Lavedán E, Ballester F, Cordier S, Costet N, Espinosa A, Grazuleviciene R, Danileviciute A, Ibarluzea J, Karadanelli M, Krasner S, Patelarou E, Stephanou E, Tardón A, Toledano MB, Wright J, Villanueva CM, Nieuwenhuij. Drinking water disinfection by products, genetic polymorphisms, and birth outcomes in a European mother-child cohort study. Epidemiology. 2016 Nov;27(6):903-11.PMID: 27468006
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražuleviien R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen A. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environ Health Perspect. 2016 Nov;124(11):1785-1793. PMID: 27152464
La biomonitorización de sustancias tóxicas en muestras biológicas de población general
Ibarluzea J, Aurrekoetxea JJ, Porta M, Sunyer J, Ballester F. La biomonitorización de sustancias tóxicas en muestras biológicas de población general. Gac Sanit. 2016 Nov;30 Suppl 1:45-54.PMID: 27132480
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy
Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, Postma DS, Valenta R, Wickman M, Cambon-Thomsen A, Haahtela T, Lambrecht BN, Lodrup Carlsen KC, Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Fo. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy. Allergy. 2016 Nov;71(11):1513-1525. PMID: 26970340
Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study
Fernández-Barrés S, Romaguera D, Valvi D, Martínez D, Vioque J, Navarrete-Muñoz EM, Amiano P, Gonzalez-Palacios S, Guxens M, Pereda E, Riaño I, Tardón A, Iñiguez C, Arija V, Sunyer J, Vrijheid M; INMA Project. Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study. Pediatr Obes. 2016 Dec;11(6):491-499. PMID: 26763767
Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe
Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Antipkin Y, Saurel-Cubizolles MJ, Lioret S, Vrijheid M, Torrent M, Iñiguez C, Larrañaga I, Bakoula C, Veltsista A, van Eijsden M, Vrijkotte TG, Andrýsková L, Dušek L, Barros H, Cor. Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe. Paediatr Perinat Epidemiol. 2016 May;30(3):274-84. PMID: 26945670
Prenatal mercury exposure and birth outcomes
Murcia M, Ballester F, Enning AM, Iñiguez C, Valvi D, Basterrechea M, Rebagliato M, Vioque J, Maruri M, Tardon A, Riaño-Galán I, Vrijheid M, Llop S. Prenatal mercury exposure and birth outcomes. Environ Res. 2016 Jul 20;151:11-20.PMID: 27448728
The association between passive and active tobacco smoke exposure and child weight status among Spanish children
Robinson O, Martínez D, Aurrekoetxea JJ, Estarlich M, Somoano AF, Íñiguez C, Santa-Marina L, Tardón A, Torrent M, Sunyer J, Valvi D, Vrijheid M. The association between passive and active tobacco smoke exposure and child weight status among Spanish children. Obesity (Silver Spring). 2016 Aug;24(8):1767-77. PMID: 27367931
Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort
Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Martinez D, Ibarluzea J, Santa-Marina L, Schettgen T, Vioque J, Sunyer J, Vrijheid M. Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort. Environ Int. 2016 Jul-Aug;92-93:357-65.PMID: 27132161
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