Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts
Strandberg-Larsen K, Poulsen G, Bech BH, Chatzi L, Cordier S, Dale MTG, Fernandez M, Henriksen TB, Jaddoe VW, Kogevinas M, Kruithof CJ, Lindhard MS, Magnus P, Nohr EA, Richiardi L, Rodriguez-Bernal CL, Rouget F, Rusconi F, Vrijheid M, Andersen AN. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. Eur J Epidemiol. 2017 Sep;32(9):751-764. PMID: 29027084
Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Martinez D, Romaguera D, Fernández-Barrés S, Santa-Marina L, Basterretxea M, Schettgen T, Valvi D, Vioque J, Sunyer J, Vrijheid M. Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study. Environ Health Perspect. 2017 Sep 20;125(9):097018. PMID: 28934720
Neuropsychological Assessment at Preschool Age: Adaptation and Validation of the McCarthy Scales of Children’s Abilities to 4 Year-old Basque-speaking Children
Andiarena A, Balluerka N, Gorostiaga A, Ibarluzea J. Neuropsychological Assessment at Preschool Age: Adaptation and Validation of the McCarthy Scales of Children’s Abilities to 4 Year-old Basque-speaking Children. Span J Psychol. 2017 Oct 23;20:E49. PMID: 29056101
Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts
Matilla-Santander N, Valvi D, Lopez-Espinosa MJ, Manzano-Salgado CB, Ballester F, Ibarluzea J, Santa-Marina L, Schettgen T, Guxens M, Sunyer J, Vrijheid M. Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts. Environ Health Perspect. 2017 Nov 13;125(11):117004. PMID: 29135438
Urban green and grey space in relation to respiratory health in children
Tischer C, Gascon M, Fernández-Somoano A, Tardón A, Lertxundi Materola A, Ibarluzea J, Ferrero A, Estarlich M, Cirach M, Vrijheid M, Fuertes E, Dalmau-Bueno A, Nieuwenhuijsen MJ, Antó JM, Sunyer J, Dadvand P. Urban green and grey space in relation to respiratory health in children. Eur Respir J. 2017 Jun 22;49(6). PMID: 28642307
Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe
Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A, Bousquet J, Chatzi L, Fantini MP, Ferrero A, Gehring U, Gori D, Heinrich J, Keil T, Kull I, Lau S, Maier D, Momas I, Narduzzi S, Porta D, Ranciere F, Roumeliotaki T, Schikowski T, Smit HA, Standl M, Sunyer J, Wright J. Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017 Jul 3;3(3). PMID: 28845428
Dietary intake of trans fatty acids in children aged 4-5 in Spain: the INMA cohort study
Scholz A, Gimenez-Monzo D, Navarrete-Muñoz EM, Garcia-de-la-Hera M, Fernandez-Somoano A, Tardon A, Santa Marina L, Irazabal A, Romaguera D, Guxens M, Julvez J, Llop S, Lopez-Espinosa MJ, Vioque J. Dietary Intake of Trans Fatty Acids in Children Aged 4-5 in Spain: The INMA Cohort Study. Nutrients. 2016 Oct 10;8(10). pii: E625. PMID: 27735864
Environment and Brain Development: Challenges in the Global Context
Júlvez J, Paus T, Bellinger D, Eskenazi B, Tiemeier H, Pearce N, Ritz B, White T, Ramchandani P, Gispert JD, Desrivières S, Brouwer R, Boucher O, Alemany S, López-Vicente M, Suades-González E, Forns J, Grandjean P, Sunyer J. Environment and Brain Development: Challenges in the Global Context. Neuroepidemiology. 2016;46(2):79-82. PMID: 26684467
Acetaminophen Use in Pregnancy and Neurodevelopment: Attention Function and Autism Spectrum Symptoms
Avella-Garcia CB, Julvez J, Fortuny J, Rebordosa C, García-Esteban R, Galán IR, Tardón A, Rodríguez-Bernal CL, Iñiguez C, Andiarena A, Santa-Marina L, Sunyer J. Acetaminophen Use in Pregnancy and Neurodevelopment: Attention Function and Autism Spectrum Symptoms. Int J Epidemiol. 2016 Dec 1;45(6):1987-1996. PMID: 27353198
Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study
Maitre L, Villanueva CM, Lewis MR, Ibarluzea J, Santa-Marina L, Vrijheid M, Sunyer J, Coen M, Toledano MB. Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study. BMC Med.2016 Nov 4;14(1):177. PMID: 27814705
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