Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
-
Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
-
Entidades Colaboradoras:
Search
Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders
Cilleros-Portet A, Lesseur C, Marí S, Cosin-Tomas M, Lozano M, Irizar A, Burt A, García-Santisteban I, Garrido-Martín D, Escaramís G, Hernangomez-Laderas A, Soler-Blasco R, Breeze CE, Gonzalez-Garcia BP, Santa-Marina L, Chen J, Llop S, Fernández MF, Vrijheid M, Ibarluzea J, Guxens M, Marsit C, Bustamante M, Bilbao JR, Fernandez-Jimenez N. Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. Nat Commun. 2025 Mar 14;16(1):2431. PMID: 40087310
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, Thijs C. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. PMID: 39147399
Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes
Borges MC, Clayton GL, Freathy RM, Felix JF, Fernández-Sanlés A, Soares AG, Kilpi F, Yang Q, McEachan RRC, Richmond RC, Liu X, Skotte L, Irizar A, Hattersley AT, Bodinier B, Scholtens DM, Nohr EA, Bond TA, Hayes MG, West J, Tyrrell J, Wright J, Bouchard L, Murcia M, Bustamante M, Chadeau-Hyam M, Jarvelin MR, Vrijheid M, Perron P, Magnus P, Gaillard R, Jaddoe VWV, Lowe WL Jr, Feenstra B, Hivert MF, Sørensen TIA, Håberg SE, Serbert S, Magnus M, Lawlor DA. Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes. BMC Med. 2024 Jan 29;22(1):32. PMID: 38281920
Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis
Binter AC, Ghassabian A, Zou R, El Marroun H, Lertxundi A, Switkowski KM, Estarlich M, Rodríguez-Dehli AC, Esplugues A, Vrijkotte T, Sunyer J, Santa-Marina L, Fernández-Somoano A, Polanska K, McEachan RRC, Oken E, Tiemeier H, Guxens M. Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis. J Clin Endocrinol Metab. 2024 Jun 13:dgae395. doi: 10.1210/clinem/dgae395. Epub ahead of print. PMID: 38870315
Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
Freire C, Castiello F, Babarro I, Anguita-Ruiz A, Casas M, Vrijheid M, Sarzo B, Beneito A, Kadawathagedara M, Philippat C, Thomsen C, Sakhi AK, Lopez-Espinosa MJ. Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts. Int J Hyg Environ Health. 2024 Aug;261:114418. PMID: 38968838
Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
Fernandes A, Avraam D, Cadman T, Dadvand P, Guxens M, Binter AC, Pinot de Moira A, Nieuwenhuijsen M, Duijts L, Julvez J, De Castro M, Fossati S, Márquez S, Vrijkotte T, Elhakeem A, McEachan R, Yang T, Pedersen M, Vinther J, Lepeule J, Heude B, Jaddoe VWV, Santos S, Welten M, El Marroun H, Mian A, Andrušaitytė S, Lertxundi A, Ibarluzea J, Ballester F, Esplugues A, Torres Toda M, Harris JR, Lucia Thorbjørnsrud Nader J, Moirano G, Maritano S, Catherine Wilson R, Vrijheid M. Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children. Environ Int. 2024 Aug;190:108853. PMID: 38963986
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
Koch S, Peralta GP, Carsin AE, Abellan A, Roda C, Torrent M, Iñiguez C, Ballester F, Ferrero A, Zabaleta C, Lertxundi A, Guxens M, Vrijheid M, Sunyer J, Casas M, Garcia-Aymerich J. Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study. Thorax. 2024 Jul 16;79(8):762-769. PMID: 38448222
Ambient air temperature exposure and foetal size and growth in three European birth cohorts
Essers E, Granés L, Delaney S, Ballester J, Santos S, Petricola S, Yang TC, Fernández-Somoano A, Bereziartua A, Ballester F, Tardón A, Vrijheid M, Lertxundi A, McEachan RRC, El Marroun H, Tiemeier H, Iñiguez C, Guxens M. Ambient air temperature exposure and foetal size and growth in three European birth cohorts. Environ Int. 2024 Apr;186:108619. PMID: 38603813
The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort
Sarzo B, Ballester F, Soler-Blasco R, Sunyer J, Lopez-Espinosa MJ, Ibarluzea J, Lozano M, Julvez J, Iriarte G, Subiza-Perez M, González-Safont L, Fernández-Somoano A, Vallejo-Ortega J, Guxens M, López-González UA, Riaño-Galán I, Riutort-Mayol G, Murcia M, Llop S. The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort. Environ Res. 2024 Jul 1;252(Pt 2):118954. PMID: 38631469
Socioeconomic position, family context, and child cognitive development
González L, Popovic M, Rebagliato M, Estarlich M, Moirano G, Barreto-Zarza F, Richiardi L, Arranz E, Santa-Marina L, Zugna D, Ibarluzea J, Pizzi C. Socioeconomic position, family context, and child cognitive development. Eur J Pediatr. 2024 Jun;183(6):2571-2585. PMID: 38483609
1 / 33
