Granada

2001. urtean, emakume haurdunen kohortea biltzeari ekin zitzaion Granadako Ospitale Klinikoan eta Almeriako “Hospital de Poniente”n. Helburu nagusia, hain zuzen ere, gizonezko jaioberrien gernu-hodian ematen diren malformazioen garrantzia aztertzea zen.

Ildo horretan, ikerlariak ondorengo erlazioa frogatzen saiatu ziren: ama denbora luzez egoten bazen disruptore endokrinoekin kontaktuan (eta horiek dira jarduera hormonala duten ingurumeneko konposatu kimikoak), umeak kriptorkidia eta hipospadiak izan zitzakeen.

Hori zela eta, semeak izandako 700en bat emakume bildu zituzten, eta haietatik 50etik gora kasu indexaturik zeuden (kriptorkidia eta/edo hipospadiak). Horrekin batera, 150 jaioberriren kontrol-ikerketa bat jarri zen martxan, amaren dietari azido folikoa gehituta haurdunaldian.

Ama-semeen eta jaiotzen kohortea oso informazio erabilgarria ematen ari da jarduera hormonala duten konposatu kimikoekiko ama-haurren esposizioaz. Hasi diren ikerketa hauek zenbait puntu agerian uzteko balio izan dute: alde batetik, amaren esposizioaren garrantzia, eta, bestaldetik, Europako beste lurraldeekiko dauden eskualde-desberdintasunak. Esposizio-markatzaileen aplikazio gehigarria erabilgarri suertatzen ari da, konposatu kimikoen eta efektu-hormonalaren arteko elkarreragina ezagutu ahal izateko.

 

  • Entidades Colaboradoras:

Buscador

98 Resultados

Compuestos tóxicos no persistentes -
Neurodesarrollo -


Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach

Rodríguez-Carrillo A, D Cruz SC, Mustieles V, Suárez B, Smagulova F, David A, Peinado F, Artacho-Cordón F, López LC, Arrebola JP, N O, Fernández MF, Freire C. Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach. Environ Res. 2022 Aug;211:113115. PMID: 35292247


Compuestos tóxicos no persistentes -
Neurodesarrollo -


Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males

Rodríguez-Carrillo A, Mustieles V, D’Cruz SC, Legoff L, Gil F, Olmedo P, Reina-Pérez I, Mundo A, Molina M, Smagulova F, David A, Freire C, Fernández MF. Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males. Int J Hyg Environ Health. 2022 Jan;239:113877. PMID: 34757248


Compuestos tóxicos no persistentes -
Neurodesarrollo -


BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort

Mustieles V, Rodríguez-Carrillo A, Vela-Soria F, D’Cruz SC, David A, Smagulova F, Mundo-López A, Olivas-Martínez A, Reina-Pérez I, Olea N, Freire C, Arrebola JP, Fernández MF. BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort. Sci Total Environ. 2022 Jan 10;803:150014. PMID: 34788942


Nutrición -
Vitamina D -


Biochemical Validation of a Self-Administered Food Frequency Questionnaire to Assess Diet Using Carotenoids and Vitamins E and D in Male Adolescents in SpainBiochemical Validation of a Self-Administered Food Frequency Questionnaire to Assess Diet Using Carotenoids and Vitamins E and D in Male Adolescents in Spain

Notario-Barandiaran L, Navarrete-Muñoz EM, Valera-Gran D, Hernández-Álvarez E, Donoso-Navarro E, González-Palacios S, García-de-la-Hera M, Fernández MF, Freire C, Vioque J. Biochemical Validation of a Self-Administered Food Frequency Questionnaire to Assess Diet Using Carotenoids and Vitamins E and D in Male Adolescents in Spain. Antioxidants (Basel). 2021 May 8;10(5):750. PMID: 34066826


Compuestos tóxicos no persistentes -


Determination of bisphenols, parabens, and benzophenones in placenta by dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry

Fernández MF, Mustieles V, Suárez B, Reina-Pérez I, Olivas-Martinez A, Vela-Soria F. Determination of bisphenols, parabens, and benzophenones in
placenta by dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry. Chemosphere. 2021 Jul;274:129707. PMID: 33545592


Alteraciones hormonales -
Compuestos tóxicos no persistentes -


Urinary metabolites of non-persistent pesticides and serum hormones in Spanish adolescent males

Freire C, Suárez B, Vela-Soria F, Castiello F, Reina-Pérez I, Andersen HR, Olea N, Fernández MF. Urinary metabolites of non-persistent pesticides and serum hormones in Spanish adolescent males. Environ Res. 2021 Jun;197:111016. PMID: 33771511


Compuestos tóxicos persistentes -


Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas

Rodríguez-Carrillo A, Rosenmai AK, Mustieles V, Couderq S, Fini JB, Vela-Soria F, Molina-Molina JM, Ferrando-Marco P, Wielsøe M, Long M, Bonefeld-Jorgensen EC, Olea N, Vinggaard AM, Fernández MF. Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas. Reprod Toxicol. 2021 Mar;100:143-154. PMID: 33444715


Alteraciones hormonales -
Compuestos tóxicos persistentes -
Genética -


Organophosphate pesticide exposure, hormone levels, and interaction with PON1 polymorphisms in male adolescents

Suárez B, Vela-Soria F, Castiello F, Olivas-Martinez A, Acuña-Castroviejo D, Gómez-Vida J, Olea N, Fernández MF, Freire C. Organophosphate pesticide exposure, hormone levels, and interaction with PON1 polymorphisms in male adolescents. Sci Total Environ. 2021 May 15;769:144563. PMID: 33485193


Exposoma -
General sobre el proyecto -


Applying the exposome concept in birth cohort research: a review of statistical approaches

Santos S, Maitre L, Warembourg C, Agier L, Richiardi L, Basagaña X, Vrijheid M. Applying the exposome concept in birth cohort research: a review of statistical approaches. Eur J Epidemiol. 2020 Mar;35(3):193-204. PMID: 32221742


Nutrición -


Reproducibility and Validity of a Food Frequency Questionnaire for Dietary Assessment in Adolescents in a Self-Reported Way

Notario-Barandiaran L, Freire C, García-de-la-Hera M, Compañ-Gabucio LM, Torres-Collado L, González-Palacios S, Mundo A, Molina M, Fernández MF, Vioque J. Reproducibility and Validity of a Food Frequency Questionnaire for Dietary Assessment in Adolescents in a Self-Reported Way. Nutrients. 2020 Jul 14;12(7):2081. PMID: 32674463


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