Gipuzkoa

2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.

Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.

Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.

  • Financiadores de la cohorte INMA-Gipuzkoa:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Entidades Colaboradoras:

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269 Resultados

Compuestos tóxicos persistentes -
Neurodesarrollo -


Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies

Forns J, Verner MA, Iszatt N, Nowack N, Bach CC, Vrijheid M, Costa O, Andiarena A, Sovcikova E, Høyer BB, Wittsiepe J, Lopez-Espinosa MJ, Ibarluzea J, Hertz-Picciotto I, Toft G, Stigum H, Guxens M, Liew Z, Eggesbø M. Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies. Environ Health Perspect. 2020 May;128(5):57002. PMID: 32378965


Crecimiento postnatal y Obesidad -
General sobre el Proyecto -
Neurodesarrollo -
Salud respiratoria y atopia -


The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Jaddoe VWV, Felix JF, Andersen AN, Charles MA, Chatzi L, Corpeleijn E, Donner N, Elhakeem A, Eriksson JG, Foong R, Grote V, Haakma S, Hanson M, Harris JR, Heude B, Huang RC, Inskip H, Järvelin MR, Koletzko B, Lawlor DA, Lindeboom M, McEachan RRC, Mikkola TM, Nader JLT, de Moira AP, Pizzi C, Richiardi L, Sebert S, Schwalber A, Sunyer J, Swertz MA, Vafeiadi M, Vrijheid M, Wright J, Duijts L; LifeCycle Project Group. The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. Eur J Epidemiol. 2020 Jul;35(7):709-724. PMID: 32705500


Contaminación del aire -
Salud respiratoria y atopia -


Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts

Fuertes E, Sunyer J, Gehring U, Porta D, Forastiere F, Cesaroni G, Vrijheid M, Guxens M, Annesi-Maesano I, Slama R, Maier D, Kogevinas M, Bousquet J, Chatzi L, Lertxundi A, Basterrechea M, Esplugues A, Ferrero A, Wright J, Mason D, McEachan R, Garcia-Aymerich J, Jacquemin B. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts. Environ Int. 2020 Mar;136:105474. PMID: 31962272


Compuestos tóxicos persistentes -
Neurodesarrollo -


Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project

Freire C, Vela-Soria F, Beneito A, Lopez-Espinosa MJ, Ibarluzea J, Barreto FB, Casas M, Vrijheid M, Fernandez-Tardon G, Riaño-Galan I, Fernandez MF; INMA Project. Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project. Int J Hyg Environ Health. 2020 Aug 11;230:113597. PMID: 32795877


Cardiometabólico -
Contaminación del aire -


Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers

Fossati S, Valvi D, Martínez D, Cirach M, Estarlich M, Fernández-Somoano A, Guxens M, Iñiguez C, Irizar A, Lertxundi A, Nieuwenhuijsen M, Tamayo I, Vioque J, Tardón A, Sunyer J, Vrijheid M. Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers. Environ Int. 2020 May;138:105619. PMID: 32193046


Alteraciones hormonales -
Neurodesarrollo -


Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis

Levie D, Korevaar TIM, Mulder TA, Bath SC, Dineva M, Lopez-Espinosa MJ, Basterrechea M, Santa-Marina L, Rebagliato M, Sunyer J, Rayman MP, Tiemeier H, Peeters RP, Guxens M. Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis. Thyroid. 2019 Sep;29(9):1316-1326. PMID: 31426724


Alteraciones hormonales -
Contaminación del aire -


Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy

Ghassabian A, Pierotti L, Basterrechea M, Chatzi L, Estarlich M, Fernández-Somoano A, Fleisch AF, Gold DR, Julvez J, Karakosta P, Lertxundi A, Lopez-Espinosa MJ, Mulder TA, Korevaar TIM, Oken E, Peeters RP, Rifas-Shiman S, Stephanou E, Tardón A, Tiemeier H, Vrijheid M, Vrijkotte TGM, Sunyer J, Guxens M. Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy. JAMA Netw Open. 2019 Oct 2;2(10):e1912902. PMID: 31617922


Alteraciones hormonales -
Salud reproductiva -


Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis

Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan C, Boucai L, Vafeiadi M, Grineva EN, Tkachuck AS, Pop VJM, Vrijkotte TG, Guxens M, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Murcia M, Lu X, Mukhtar S, Delles C, Feldt-Rasmussen U, Nelson SM, Alexander EK, Chaker L, Männistö T, Walsh JP, Pearce EN, Steegers EAP, Peeters RP. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis. JAMA. 2019 Aug 20;322(7):632-641. PMID: 31429897


Actividad física - sedentarismo -
Cardiometabólico -
Crecimiento postnatal y Obesidad -
Nutrición -


Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study

Bawaked RA, Fernández-Barrés S, Navarrete-Muñoz EM, González-Palacios S, Guxens M, Irizar A, Lertxundi A, Sunyer J, Vioque J, Schröder H, Vrijheid M, Romaguera D. Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study. Pediatr Obes. 2020 Mar;15(3):e12590 PMID: 31793235


Neurodesarrollo -
Nutrición -


Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes

Julvez J, Fernández-Barrés S, Gignac F, López-Vicente M, Bustamante M, Garcia-Esteban R, Vioque J, Llop S, Ballester F, Fernández-Somoano A, Tardón A, Vrijheid M, Tonne C, Ibarluzea J, Irazabal A, Sebastian-Galles N, Burgaleta M, Romaguera D, Sunyer J. Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes. Int J Epidemiol. 2020 Apr 1;49(2):559-571 PMID: 31578044


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