Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Cohort Profile: The INMA–INfancia y Medio Ambiente–(Environment and Childhood) Project
Guxens M, Ballester F, Espada M, Fernández MF, Grimalt JO, Ibarluzea J, Olea N, Rebagliato M, Tardón A, Torrent M, Vioque J, Vrijheid M, Sunyer J; on behalf of INMA Project. Cohort Profile: The INMA –INfancia y Medio Ambiente–(Environment and Childhood) Project. Int J Epidemiol. 2012 Aug;41(4):930-940. PMID: 21471022
Exposure to second hand smoke and reproductive outcomes depending on maternal asthma
Sunyer J, Garcia-Esteban R, Castilla AM, Aurrekoetxea JJ, Iñiguez C, Tardón A, Espada M, Lertxundi A, Chatzi L, Rebagliato M, Kogevinas M; on behalf of the INMA project. Exposure to second hand smoke and reproductive outcomes depending on maternal asthma. Eur Respir J. 2012 Aug;40(2):371-376. PMID: 22323568
Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
Bustamante M, Danileviciute A, Espinosa A, Gonzalez J, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva C, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG.2012 Aug;119(9):1141-1146. PMID: 22676722
Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Forns J, Lertxundi N, Aranbarri A, Murcia M, Gascon M, Martinez D, Grellier J, Lertxundi A, Julvez J, Fano E, Goñi F, Grimalt JO, Ballester F, Sunyer J, Ibarluzea J. Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life. Environ Int.2012 May 8;45C:72-77. PMID: 22575806
Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze
Gascon M, Vrijheid M, Martínez D, Ballester F, Basterrechea M, Blarduni E, Esplugues A, Vizcaino E, Grimalt JO, Morales E, Sunyer J; on behalf of the Infancia y Medio Ambiente (Environment and Childhood) (INMA) project. Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze. Eur Respir J. 2012 May;39(5):1188-1196. PMID: 22075485
Prenatal Exposure to Mercury and Infant Neurodevelopment in a Multicenter Cohort in Spain: Study of Potential Modifiers
Llop S, Guxens M, Murcia M, Lertxundi A, Ramon R, Riaño I, Rebagliato M, Ibarluzea J, Tardon A, Sunyer J, Ballester F; on Behalf of the INMA Project. Prenatal Exposure to Mercury and Infant Neurodevelopment in a Multicenter Cohort in Spain: Study of Potential Modifiers. Am J Epidemiol. 2012 Mar 1;175(5):451-465.PMID: 22287639
Socioeconomic status and exposure to multiple environmental pollutants during pregnancy: evidence for environmental inequity?
Vrijheid M, Martinez D, Aguilera I, Ballester F, Basterrechea M, Esplugues A, Guxens M, Larrañaga M, Lertxundi A, Mendez M, Murcia M, Santa Marina L, Villanueva CM, Sunyer J. Socioeconomic status and exposure to multiple environmental pollutants during pregnancy: evidence for environmental inequity?.J Epidemiol Community Health. 2012 Feb;66(2):106-13. PMID: 20974841
Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts
Govarts E, Nieuwenhuijsen M, Schoeters G, Ballester F, Bloemen K, de Boer M, Chevrier C, Eggesbø M, Guxens M, Krämer U, Legler J, Martinez D, Palkovi?ová L, Patelarou E, Ranft U, Rautio A, Petersen MS, Slama R, Stigum H, Toft G, Trnovec T, Vandentorr. Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts. Environ Health Perspect. 2012 Feb;120(2):162-70. PMID: 21997443
Prenatal Exposure to Residential Air Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification Factors
Guxens M, Aguilera I, Ballester F, Estarlich M, Fernández-Somoano A, Lertxundi A, Lertxundi N, Mendez MA, Tardón A, Vrijheid M, Sunyer J. Prenatal Exposure to Residential Air Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification Factors. Environ Health Perspect. 2012 Jan;120(1):144-9. PMID: 21868304
European birth cohorts for environmental health research
Vrijheid M, Casas M, Bergström A, Carmichael A, Cordier S, Eggesbø M, Eller E, Fantini MP, Fernández MF, Fernández-Somoano A, Gehring U, Grazuleviciene R, Hohmann C, Karvonen AM, Keil T, Kogevinas M, Koppen G, Krämer U, Kuehni CE, Magnus P, Majewska. European birth cohorts for environmental health research. Environ Health Perspect. 2012 Jan;120(1):29-37. PMID: 21878421
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