Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study
Aurrekoetxea JJ, Murcia M, Rebagliato M, López MJ, Castilla AM, Santa-Marina L, Guxens M, Fernández-Somoano A, Espada M, Lertxundi A, Tardón A, Ballester F. Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study. BMJ Open. 2013 Jan 24;3(1).
Prenatal and postnatal residential usage of insecticides in a multicenter birth cohort in Spain
Llop S, Casas L, Santa Marina L, Estarlich M, Fernández-Somoano A, Esplugues A, Jimenez A, Zock JP, Tardón A, Marco A, Ballester F. Prenatal and postnatal residential usage of insecticides in a multicenter birth cohort in Spain. Sci Total Environ. 2013 Feb 15;445-446:273-80. PMID: 23337604
Environmental exposure assessment in European birth cohorts: results from the ENRIECO project
Gehring U, Casas M, Brunekreef B, Bergström A, Bonde JP, Botton J, Chévrier C, Cordier S, Heinrich J, Hohmann C, Keil T, Sunyer J, Tischer CG, Toft G, Wickman M, Vrijheid M, Nieuwenhuijsen M. Environmental exposure assessment in European birth cohorts: results from the ENRIECO project. Environ Health. 2013 Jan 23;12:8. PMID: 23343014
Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies.
Casas M, Chatzi L, Carsin AE, Amiano P, Guxens M, Kogevinas M, Koutra K, Lertxundi N, Murcia M, Rebagliato M, Riaño I, Rodríguez-Bernal CL, Roumeliotaki T, Sunyer J, Mendez M, Vrijheid M. Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies. Int J Epidemiol. 2013 Apr;42(2):506-17. PMID: 23569191
Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy
Morales E, Gascon M, Martinez D, Casas M, Ballester F, Rodríguez-Bernal CL, Ibarluzea J, Marina LS, Espada M, Goñi F, Vizcaino E, Grimalt JO, Sunyer J; on behalf of the INMA Project. Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy. Environ Int.2013 Jul;57-58:34-41. PMID: 23651836
Pooling birth cohorts in allergy and asthma: European Union-funded initiatives – a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper
Bousquet J, Anto J, Sunyer J, Nieuwenhuijsen M, Vrijheid M, Keil T; MeDALL Study Group; CHICOS Study Group; ENRIECO Study Group; GA²LEN Study Group. Pooling birth cohorts in allergy and asthma: European Union-funded initiatives – a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper. Int Arch Allergy Immunol. 2013;161(1):1-10. PMID: 23258290
Male specific association between xenoestrogen levels in placenta and birthweight
Vilahur N, Molina-Molina JM, Bustamante M, Murcia M, Arrebola JP, Ballester F, Mendez MA, Garcia-Esteban R, Guxens M, Santa Marina L, Tardón A, Sunyer J, Olea N, Fernandez MF. Male specific association between xenoestrogen levels in placenta and birthweight. Environ Int. 2013 Jan;51:174-81. PMID: 23262415
Current dietary exposure to mercury during pregnancy and childhood, and public health recommendations
Llop S, Ibarlucea J, Sunyer J, Ballester F. Current dietary exposure to mercury during pregnancy and childhood, and public health recommendations. Gac Sanit. 2013 May-Jun;27(3):273-8. Spanish.PMID: 23122516
Early Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study
Aguilera I, Pedersen M, Garcia-Esteban R, Ballester F, Basterrechea M, Esplugues A, Fernández-Somoano A, Lertxundi A, Tardón A, Sunyer J. Early Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study. Environ Health Perspect. 2013 Mar;121(3):387-92.PMID: 23221880
Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children
Gascon M, Verner MA, Guxens M, Grimalt JO, Forns J, Ibarluzea J, Lertxundi N, Ballester F, Llop S, Haddad S, Sunyer J, Vrijheid M. Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children. Neurotoxicology. 2013 Jan;34:9-15. PMID: 23085522
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