Gipuzkoa
2006ko maiatzean, “Haurtzaroa eta Ingurumena” (INMA) proiektua jarri zen martxan Gipuzkoan. Helburu nagusia zen airean, uretan eta dietan aurkitzen diren ingurumen-kutsatzaileek haurren hazkuntzan etagarapenean izan dezaketen eragina aztertzea. Emakumeak haurdunaldiko kontrolaren lehen ekografia egitean sartzen dira kohortean.Lagin biologikoak (odola, gernua, ilea, plazenta, eta abar) jasotzeaz gain, zenbait galdesorta (orokorra, dietaz, lanaz, ingurugiroaz, eta abar) betetzen dira, batetik, airean, ingurugiroan eta kontsumoko uretan aurkitzen diren kutsatzaileen balorazioa egiteko, eta, bestetik, dieta bidez jasotako kutsatzaileen estimazioa ateratzeko.
Zumarragako Ospitaleari dagokion biztanleriak definitzen du ikerketaren inguru geografikoa, hau da, Goierriko eta Urola Garaiko nahiz Urola Erdiko udalerriak. Inguru hori aukeratu zen, hain zuen, lehen mailako arreta eskaintzeagatik eta ospitaleko zerbitzuen ezaugarriengatik, eta baita ingurumen ezaugarriengatik ere: industria siderometalurgiko ugaria, zirkulazio-dentsitate altua, desinfektatzetik eratorritako produktuen maila baxua edateko uretan, arrain ugariko dieta, eta, horiekin batera, hipotiroidismo pixka bat emakume haurdunengan.
Orduz geroztik, 640 emakumeren jarraipena egin da haurdunaldiaren lehenengo eta hirugarren hilabeteetan. Gaur egun, 623 haurren jarraipena egiten ari gara hazkuntzaren eta garapen neurokonduktualaren gainean.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
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First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
Costa O, Iñiguez C, Manzano-Salgado CB, Amiano P, Murcia M, Casas M, Irizar A, Basterrechea M, Beneito A, Schettgen T, Sunyer J, Vrijheid M, Ballester F, Lopez-Espinosa MJ. First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy. Environ Int. 2019 Sep;130:104830. PMID: 31247476
Association between trans fatty acid intake and overweight including obesity in 4 to 5-year-old children from the INMA study
Scholz A, Navarrete-Muñoz EM, García-de-la-Hera M, Fernandez-Somoano A, Tardon A, Santa-Marina L, Pereda-Pereda E, Romaguera D, Guxens M, Beneito A, Iñiguez C, Vioque J. Association between trans fatty acid intake and overweight including obesity in 4 to 5-year-old children from the INMA study. Pediatr Obes. 2019 Sep;14(9):e12528. PMID: 30957427
Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García-Villarino M, Fernández-Somoano A, Tardón A, Santa-Marina L, Irizar A, Casas M, Guxens M, Llop S, Soler-Blasco R, García-de-la-Hera M, Karagas MR, Meharg AA. Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain. Environ Res. 2019 Jul;174:135-142. PMID: 31075694
Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts
Tsarna E, Reedijk M, Birks LE, Guxens M, Ballester F, Ha M, Jiménez-Zabala A, Kheifets L, Lertxundi A, Lim HR, Olsen J, González Safont L, Sudan M, Cardis E, Vrijheid M, Vrijkotte T, Huss A, Vermeulen R. Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts. Am J Epidemiol. 2019 Jul 1;188(7):1270-1280. PMID: 30995291
Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts
Dineva M, Rayman MP, Levie D, Guxens M, Peeters RP, Vioque J, González L, Espada M, Ibarluzea J, Sunyer J, Korevaar TIM, Bath SC. Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts. Eur J Nutr. 2020 Feb;59(1):371-387. PMID: 30734058
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Middeldorp CM, Felix JF, Mahajan A; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium, McCarthy MI. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. 2019 Mar;34(3):279-300. PMID: 30887376
Prenatal exposure to PM2.5 and NO2 and sex-dependent infant cognitive and motor development
Lertxundi A, Andiarena A, Martínez MD, Ayerdi M, Murcia M, Estarlich M, Guxens M, Sunyer J, Julvez J, Ibarluzea J. Prenatal exposure to PM2.5 and NO2 and sex-dependent infant cognitive and motor development. Environ Res. 2019 Jul;174:114-121. PMID: 31055169
Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study
Manzano-Salgado CB, Granum B, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Gascón M, Martínez D, Guxens M, Basterretxea M, Zabaleta C, Schettgen T, Sunyer J, Vrijheid M, Casas M. Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study. Int J Hyg Environ Health. 2019 Jul;222(6):945-954. PMID: 31262703
Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms
López-Vicente M, Ribas Fitó N, Vilor-Tejedor N, Garcia-Esteban R, Fernández-Barrés S, Dadvand P, Murcia M, Rebagliato M, Ibarluzea J, Lertxundi A, Fernández-Somoano A, Tardón A, López-Sabater MC, Romaguera D, Vrijheid M, Sunyer J, Julvez J. Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms. J Pediatr. 2019 Jun;209:204-211. PMID: 30929929
Influence of the Urban Exposome on Birth Weight
Nieuwenhuijsen MJ, Agier L, Basagaña X, Urquiza J, Tamayo-Uria I, Giorgis-Allemand L, Robinson O, Siroux V, Maitre L, de Castro M, Valentin A, Donaire D, Dadvand P, Aasvang GM, Krog NH, Schwarze PE, Chatzi L, Grazuleviciene R, Andrusaityte S, Dedele A, McEachan R, Wright J, West J, Ibarluzea J, Ballester F, Vrijheid M, Slama R. Influence of the Urban Exposome on Birth Weight. Environ Health Perspect. 2019 Apr;127(4):47007. doi: 10.1289/EHP3971. PMID: 31009264
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