Gipuzkoa
En mayo 2006 se pone en marcha en Gipuzkoa el proyecto “Infancia y Medio Ambiente (INMA)” con objeto de evaluar el papel de los contaminantes ambientales presentes en el aire, agua y dieta en el crecimiento y desarrollo de los niños. La incorporación de las mujeres a la cohorte se realiza coincidiendo con la primera ecografía de control de embarazo. Se recogen muestras biológicas (sangre, orina, pelo, placenta, etc.) y se cumplimentan una serie de cuestionarios (general, dieta, laboral, ambiental, etc.) realizándose la valoración de los contaminantes presentes en el aire ambiente y en el agua de consumo, así como una estimación de los contaminantes aportados por la dieta.
El ámbito geográfico del estudio viene definido por la población de referencia del Hospital de Zumarraga que incluye los municipios del Goierri y del Alto y Medio Urola. Este entorno fue seleccionado por las características de los servicios del hospital y atención primaria implicados, así como por las características ambientales: fuerte presencia de industria siderometalurgica, alta densidad de tráfico, bajos niveles de productos derivados de la desinfección en el agua de consumo y dieta rica en pescado, unidas a cierto grado de hipotiroidismo en las mujeres embarazadas.
Desde entonces se ha realizado el seguimiento de 640 mujeres en el primer y tercer trimestre de embarazo. Actualmente se está realizando el seguimiento de 623 niños en aspectos de crecimiento y desarrollo neuroconductal.
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Financiadores de la cohorte INMA-Gipuzkoa:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Entidades Colaboradoras:
Buscador
Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
Voerman E, Santos S, Patro Golab B, Amiano P, Ballester F, Barros H, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costet N, Crozier S, Devereux G, Eggesbø M, Ekström S, Fantini MP, Farchi S, Forastiere F, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hryhorczuk D, Huang RC, Inskip H, Iszatt N, Karvonen AM, Kenny LC, Koletzko B, Küpers LK, Lagström H, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, McAuliffe FM, McDonald SW, Mehegan J, Mommers M, Morgen CS, Mori TA, Moschonis G, Murray D, Chaoimh CN, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Ronfani L, Santos AC, Standl M, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Rossem L, von Berg A, Vrijheid M, Vrijkotte TGM, West J, Wijga A, Wright J, Zvinchuk O, Sørensen TIA, Lawlor DA, Gaillard R, Jaddoe VWV. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis. PLoS Med. 2019 Feb 11;16(2):e1002744. doi: 10.1371/journal.pmed.1002744. eCollection 2019 Feb. PMID: 30742624
Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, Voerman E, Santos S, Inskip H, Amiano P, Barros H, Charles MA, Chatzi L, Chrousos GP, Corpeleijn E, Crozier S, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Gori D, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Iñiguez C, Karvonen AM, Küpers LK, Lagström H, Lawlor DA, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, Mommers M, Morgen CS, Moschonis G, Nohr EA, Nybo Andersen AM, Oken E, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Trnovec T, van Gelder MMHJ, van Rossem L, von Berg A, Vrijheid M, Wijga A, Zvinchuk O, Sørensen TIA, Godfrey K, Jaddoe VWV, Gaillard R. Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes. JAMA. 2019 May 7;321(17):1702-1715. PMID: 31063572
Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costa O, Costet N, Crozier S, Devereux G, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Huang RC, Inskip H, Karvonen AM, Kenny LC, Koletzko B, Küpers LK, Lagström H, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, McAuliffe FM, McDonald SW, Mehegan J, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Ní Chaoimh C, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels A, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Gelder M, van Rossem L, von Berg A, Vrijheid M, Vrijkotte T, West J, Wijga AH, Wright J, Zvinchuk O, Sørensen T, Lawlor DA, Gaillard R, Jaddoe V. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. BJOG. 2019 Jul;126(8):984-995. PMID: 30786138
Maternal nut intake in pregnancy and child neuropsychological development up to 8 years old: a population‑based cohort study in Spain
Gignac F, Romaguera D, Fernández-Barrés S, Phillipat C, Garcia Esteban R, López-Vicente M, Vioque J, Fernández-Somoano A, Tardón A, Iñiguez C, Lopez-Espinosa MJ, García de la Hera M, Amiano P, Ibarluzea J, Guxens M, Sunyer J, Julvez J. Maternal nut intake in pregnancy and child neuropsychological development up to 8 years old: a population‑based cohort study in Spain. Eur J Epidemiol. 2019 Jul;34(7):661-673. PMID: 31062119
Effect modification of FADS2 polymorphisms on the association between breastfeedingand intelligence: results from a collaborative meta-analysis
Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bønnelykke K, Caspi A, Moffitt TE, Poulton R, Sajjad A, Tiemeier HW, Dalmau-Bueno A, Guxens M, Bustamante M, Santa-Marina L, Parker N, Paus T, Pausova Z, Lauritzen L, Schnurr TM, Michaelsen KF, Hansen T, Oddy W, Pennell CE, Warrington NM, Davey Smith G, Victora CG. Effect modification of FADS2 polymorphisms on the association between breastfeedingand intelligence: results from a collaborative meta-analysis. Int J Epidemiol. 2019 Feb 1;48(1):45-57. PMID: 30541029
Exposure and health risks perception of extremely low frequency and radiofrequency electromagnetic fields and the effect of providing information
Gallastegi M, Jiménez-Zabala A, Molinuevo A, Aurrekoetxea JJ, Santa-Marina L, Vozmediano L, Ibarluzea J. Exposure and health risks perception of extremely low frequency and radiofrequency electromagnetic fields and the effect of providing information. Environ Res. 2019 Feb;169:501-509. PMID: 30530090
Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors
Irizar A, Gil F, Lertxundi A, Martín-Domingo MC, Urbieta N, Molinuevo A, Ibarluzea J, Basterrechea M, Aurrekoetxea JJ, Jiménez-Zabala A, Santa-Marina L. Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors. Environ Res. 2019 Mar;170:92-100. PMID: 30576994
High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohor
Navarrete-Muñoz EM, Valera-Gran D, Garcia-de-la-Hera M, Gonzalez-Palacios S, Riaño I, Murcia M, Lertxundi A, Guxens M, Tardón A, Amiano P, Vrijheid M, Rebagliato M, Vioque J; INMA Project. High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study. Eur J Nutr. 2019 Feb;58(1):241-251. PMID: 29181588
Effect of employment and domestic load on fetal development and length of gestation in a birth cohort study
Arizo-Luque V, García AM, Estarlich M, Ballester F, Fernández-Tardón G, Tardón A, Guxens M, Vrijheid M, Lertxundi A, Santa-Marina L, Ronda-Pérez E. [Effect of employment and domestic load on fetal development and length of gestation in a birth cohort study]. Rev Esp Salud Publica. 2018 Aug 17;92. Spanish. PMID: 30106066
The Association of Mediterranean Diet during Pregnancy with Longitudinal Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood
Fernández-Barrés S, Vrijheid M, Manzano-Salgado CB, Valvi D, Martínez D, Iñiguez C, Jimenez-Zabala A, Riaño-Galán I, Navarrete-Muñoz EM, Santa-Marina L, Tardón A, Vioque J, Arija V, Sunyer J, Romaguera D; Infancia y Medio Ambiente (INMA) Project. The Association of Mediterranean Diet during Pregnancy with Longitudinal Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood. J Pediatr. 2019 Mar;206:119-127. PMID: 30429079
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