Granada
In 2001, a recruitment of pregnant women for a cohort was started in the Clinical Hospital of Granada and the Hospital of the West of Almeria, with the intention to study the relevance of malformations in the masculine genitourinary tract in new born children.
The objective was to try to demonstrate that there is a relation between the chronic exposure of the mother to environmental chemical compounds with hormonal activity, “endocrine disruptors” and the frequency of cryptorchidism and hypospadias in the descendants.
That is why approximately 700 women who had given birth to male children were recruited, 50 of them where indexed with cryptorchidism and/or hypospadias. In a parallel way, a case-control study was begun with 150 new born children with intervention in the diet during the pregnancy (supplement of folic acid to the mothers).
The cohort of mother and children is providing very useful information on the maternal-infantile exposure to chemical compounds with hormonal activity. The studies that already have begun have been useful to show the existing importance of the maternal exposure and regional differences with other European countries. The additional use of exposure markers is being a key issue in the characterisation of the interactions between chemical compounds and the resulting hormonal effect.
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Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project
Freire C, Vela-Soria F, Beneito A, Lopez-Espinosa MJ, Ibarluzea J, Barreto FB, Casas M, Vrijheid M, Fernandez-Tardon G, Riaño-Galan I, Fernandez MF; INMA Project. Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project. Int J Hyg Environ Health. 2020 Aug 11;230:113597. PMID: 32795877
Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents
Castiello F, Olmedo P, Gil F, et al. Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents. Environ Res. 2020;182:108958. PMID: 31835118
Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts
Jorcano A, Lubczyńska MJ, Pierotti L, Altug H, Ballester F, Cesaroni G, El Marroun H, Fernández-Somoano A, Freire C, Hanke W, Hoek G, Ibarluzea J, Iñiguez C, Jansen PW, Lepeule J, Markevych I, Polańska K, Porta D, Schikowski T, Slama R, Standl M, Tardon A, Vrijkotte TGM, von Berg A, Tiemeier H, Sunyer J, Guxens M. Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts. Environ Int. 2019 Oct;131:104927. PMID: 31326824
Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?
Rodríguez-Carrillo A, Mustieles V, Pérez-Lobato R, Molina-Molina JM, Reina-Pérez I, Vela-Soria F, Rubio S, Olea N, Fernández MF. Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?. Neurotoxicology. 2019 Sep;74:162-171. PMID: 31238050
Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort
Mustieles V, Casas M, Ferrando-Marco P, Ocón-Hernández O, Reina-Pérez I, Rodríguez-Carrillo A, Vela-Soria F, Pérez-Lobato R, Navarrete-Muñoz EM, Freire C, Olea N, Fernández MF. Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort. Environ Res. 2019 Jun;173:443-451. PMID: 30974370
Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project
Freire C, Amaya E, Gil F, Murcia M, LLop S, Casas M, Vrijheid M, Lertxundi A, Irizar A, Fernández-Tardón G, Castro-Delgado RV, Olea N, Fernández MF; INMA Project. Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project. Int J Hyg Environ Health. 2019 Apr;222(3):468-478. PMID: 30638867
Bisphenol A and reproductive hormones and cortisol in peripubertal boys: The INMA-Granada cohort
Mustieles V, Ocón-Hernandez O, Mínguez-Alarcón L, Dávila-Arias C, Pérez-Lobato R, Calvente I, Arrebola JP, Vela-Soria F, Rubio S, Hauser R, Olea N, Fernández MF. Bisphenol A and reproductive hormones and cortisol in peripubertal boys: The INMA-Granada cohort. Sci Total Environ. 2018 Mar 15;618:1046-1053. PMID: 29100688
Spatial and temporal variability of personal environmental exposure to radio frequency electromagnetic fields in children in Europe
Birks LE, Struchen B, Eeftens M, van Wel L, Huss A, Gajšek P, Kheifets L, Gallastegi M, Dalmau-Bueno A, Estarlich M, Fernandez MF, Meder IK, Ferrero A, Jiménez-Zabala A, Torrent M, Vrijkotte TGM, Cardis E, Olsen J, Valič B, Vermeulen R, Vrijheid M, Röösli M, Guxens M. Spatial and temporal variability of personal environmental exposure to radio frequency electromagnetic fields in children in Europe. Environ Int. 2018 Aug;117:204-214. PMID: 29754001
Prenatal co-exposure to neurotoxic metals and neurodevelopment in preschool children: The Environment and Childhood (INMA) Project
Freire C, Amaya E, Gil F, Fernández MF, Murcia M, Llop S, Andiarena A, Aurrekoetxea J, Bustamante M, Guxens M, Ezama E, Fernández-Tardón G, Olea N; INMA Project. Prenatal co-exposure to neurotoxic metals and neurodevelopment in preschool children: The Environment and Childhood (INMA) Project. Sci Total Environ. 2018 Apr 15;621:340-351. PMID: 29190557
QuEChERS and ultra-high performance liquid chromatography-tandem mass spectrometry method for the determination of parabens and ultraviolet filters in human milk samples
Vela-Soria F, Iribarne-Durán LM, Mustieles V, Jiménez-Díaz I, Fernández MF, Olea N. QuEChERS and ultra-high performance liquid chromatography-tandem mass spectrometry method for the determination of parabens and ultraviolet filters in human milk samples. J Chromatogr A. 2018 Apr 20;1546:1-9. PMID: 29525126
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