Granada
In 2001, a recruitment of pregnant women for a cohort was started in the Clinical Hospital of Granada and the Hospital of the West of Almeria, with the intention to study the relevance of malformations in the masculine genitourinary tract in new born children.
The objective was to try to demonstrate that there is a relation between the chronic exposure of the mother to environmental chemical compounds with hormonal activity, “endocrine disruptors” and the frequency of cryptorchidism and hypospadias in the descendants.
That is why approximately 700 women who had given birth to male children were recruited, 50 of them where indexed with cryptorchidism and/or hypospadias. In a parallel way, a case-control study was begun with 150 new born children with intervention in the diet during the pregnancy (supplement of folic acid to the mothers).
The cohort of mother and children is providing very useful information on the maternal-infantile exposure to chemical compounds with hormonal activity. The studies that already have begun have been useful to show the existing importance of the maternal exposure and regional differences with other European countries. The additional use of exposure markers is being a key issue in the characterisation of the interactions between chemical compounds and the resulting hormonal effect.
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Collaborating Entities:
Artacho Cordón, Francisco
Licenciado en Ciencias Biológicas. Estudiante predoctoral
Biomarcadores de exposición. Exposición a mezclas de contaminantes ambientalesCalvente Adamuz, Irene
Doctora en Ciencias Físicas. Investigadora
Exposición a Radiación No IonizanteNicolás Olea/Marieta Fernández (Laboratorio de Investigaciones Médicas Hospital Universitario, San Cecilio y Departamento de Radiología, Universidad de Granada)
Castiello, Francesca
Médica especialista en pediatría. Estudiante predoctoral en medicina y salud pública
Endocrinología pediátrica, ambiente y salud públicaHospital Universitario Clínico San Cecilio de Granada
Coordinadora Granada
Fernández Cabrera, Mariana (Marieta)
Doctora en Ciencias Químicas. Investigadora Principal
Profesora TitularUniversidad de Granada
Freire Warden, Carmen
Dra. Ciencias Ambientales (Contaminación atmosférica, mercurio, neurodesarrollo).
Cohorte INMA-Granada. Universidad de Granada. Hospital Universitario San Cecilio.
Jiménez Díaz, Inmaculada
Doctora en Ciencias Químicas. Investigadora
Metodología analítica. Determinación de distintos contaminantes ambientales (disruptores endocrinos) en diferentes matrices biológicas.INMA-Granada.
Molina Molina, José Manuel
Doctor en Ciencias Biológicas. Investigador
Biomarcadores de exposición. Exposición a mezclas de contaminantes ambientalesINMA-Granada. CIBM de Granada
Moreno Arrebola, Juan Pedro
Doctor en Farmacia. Diploma Epidemiología y Salud Pública (EASP). Investigador
Universidad de Granada
Biomonitoring
Olea Serrano, Nicolás
Catedrático Universidad de Granada. Director del Instituto de Investigación Biosanitaria (ibs.GRANADA). Investigador Principal y Responsable de Grupo
Universidad de Granada. Hospital Universitario San Cecilio
Olivas Martínez, Alicia
Degree in Biochemistry and Molecular biology. Exposure to chemical substances and risk factors in reproductive diseases.
Instituto de Investigación Biosanitaria de Granada (ibs. Granada) and University of Granada (UGR)
Pérez Lobato, Rocío
Doctora en Psicología. Investigadora
NeurodesarrolloLaboratorio de Investigaciones Médicas. Hospital Clínico Universitario San Cecilio
Vela Soria, Fernando
Doctor en Ciencias Químicas. Investigador
Metodología analítica. Determinación de distintos contaminantes ambientales (disruptores endocrinos) en diferentes matrices biológicas