Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
-
Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
-
Collaborating Entities:
Buscador
Mediterranean diet adherence during pregnancy and fetal growth: INMA (Spain) and RHEA (Greece) mother-child cohort studies
Chatzi L, Mendez M, Garcia R, Roumeliotaki T, Ibarluzea J, Tardón A, Amiano P, Lertxundi A, Iñiguez C, Vioque J, Kogevinas M, Sunyer J. Mediterranean diet adherence during pregnancy and fetal growth: INMA (Spain) and RHEA (Greece) mother-child cohort studies. Br J Nutr. 2012 Jan;107(1):135-45. PMID: 21733314
Maternal Vitamin D Status in Pregnancy and Risk of Lower Respiratory Tract Infections, Wheezing, and Asthma in Offspring
Morales E, Romieu I, Guerra S, Ballester F, Rebagliato M, Vioque J, Tardón A, Rodriguez Delhi C, Arranz L, Torrent M, Espada M, Basterrechea M, Sunyer J; on behalf of the INMA Project. Maternal Vitamin D Status in Pregnancy and Risk of Lower Respiratory Tract Infections, Wheezing, and Asthma in Offspring. Epidemiology. 2012 Jan;23(1):64-71. PMID: 22082994
Indoor Air Pollution from Gas Cooking and Neurodevelopment in Infants
Vrijheid M, Martinez D, Aguilera I, Bustamante M, Ballester F, Estarlich M, Fernandez-Somoano A, Guxens M, Lertxundi N, Martinez MD, Tardon A, Sunyer J; on behalf of the INMA Project. Indoor Air Pollution from Gas Cooking and Neurodevelopment in Infants. Epidemiology. 2012 Jan;23(1):23-32. PMID: 22082993
Exposure to Trihalomethanes through Different Water Uses and Birth Weight, Small for Gestational Age and Preterm Delivery in Spain
Villanueva CM, Gracia-Lavedan E, Ibarluzea J, Santa Marina L, Ballester F, Llop S, Tardón A, Fernandez MF, Freire C, Goñi F, Basagaña X, Kogevinas M, Grimalt JO, Sunyer J; INMA project. Exposure to Trihalomethanes through Different Water Uses and Birth Weight, Small for Gestational Age and Preterm Delivery in Spain. Environ Health Perspect. 2011 Dec;119(12):1824-30. PMID: 21810554
Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain
Estarlich M, Ballester F, Aguilera I, Fernández-Somoano A, Lertxundi A, Llop S, Freire C, Tardón A, Basterrechea M, Sunyer J, Iñiguez C. Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain. Environ Health Perspect. 2011 Sep;119(9):1333-8. PMID: 21429861
Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children
Casas L, Fernández MF, Llop S, Guxens M, Ballester F, Olea N, Irurzun MB, Rodríguez LS, Riaño I, Tardón A, Vrijheid M, Calafat AM, Sunyer J; On behalf of the INMA Project. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ Int. 2011 Jul;37(5):858-66. PMID: 21429861
Prenatal exposure to lead in Spain: Cord blood levels and associated factors
Llop S, Aguinagalde X, Vioque J, Ibarluzea J, Guxens M, Casas M, Murcia M, Ruiz M, Amurrio A, Rebagliato M, Marina LS, Fernandez-Somoano A, Tardon A, Ballester F. Prenatal exposure to lead in Spain: cord blood levels and associated factors. Sci Total Environ. 2011 May 1;409(11):2298-305. PMID: 21397928
Prenatal mercury exposure in a multicenter cohort study in Spain
Ramon R, Murcia M, Aguinagalde X, Amurrio A, Llop S, Ibarluzea J, Lertxundi A, Alvarez-Pedrerol M, Casas M, Vioque J, Sunyer J, Tardon A, Martinez-Arguelles B, Ballester F. Prenatal mercury exposure in a multicenter cohort study in Spain. Environ Int. 2011 Apr;37(3):597-604. PMID: 21239061
Sociodemographic, reproductive and dietary predictors of organochlorine compounds levels in pregnant women in Spain
Ibarluzea J, Alvarez-Pedrerol M, Guxens M, Marina LS, Basterrechea M, Lertxundi A, Etxeandia A, Goñi F, Vioque J, Ballester F, Sunyer J; on behalf of the INMA Project. Sociodemographic, reproductive and dietary predictors of organochlorine compounds levels in pregnant women in Spain. Chemosphere. 2011 Jan;82(1):114-120. PMID: 20965545
Iodine intake in a population of pregnant women. INMA mother and child cohort study, Spain
Murcia M, Rebagliato M, Espada M, Vioque J, Santa Marina L, Alvarez M, Lopez-Espinosa MJ, Leon G, Iniguez C, Basterrechea M, Guxens M, Lertxundi A, Perales A, Ballester F, Sunyer J. Iodine intake in a population of pregnant women. INMA mother and child cohort study, Spain. J Epidemiol Community Health. 2010 Dec;64(12):1094-9. PMID: 20008163
32 / 33