Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Cohort Profile: The INMA–INfancia y Medio Ambiente–(Environment and Childhood) Project
Guxens M, Ballester F, Espada M, Fernández MF, Grimalt JO, Ibarluzea J, Olea N, Rebagliato M, Tardón A, Torrent M, Vioque J, Vrijheid M, Sunyer J; on behalf of INMA Project. Cohort Profile: The INMA –INfancia y Medio Ambiente–(Environment and Childhood) Project. Int J Epidemiol. 2012 Aug;41(4):930-940. PMID: 21471022
Exposure to second hand smoke and reproductive outcomes depending on maternal asthma
Sunyer J, Garcia-Esteban R, Castilla AM, Aurrekoetxea JJ, Iñiguez C, Tardón A, Espada M, Lertxundi A, Chatzi L, Rebagliato M, Kogevinas M; on behalf of the INMA project. Exposure to second hand smoke and reproductive outcomes depending on maternal asthma. Eur Respir J. 2012 Aug;40(2):371-376. PMID: 22323568
Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
Bustamante M, Danileviciute A, Espinosa A, Gonzalez J, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva C, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG.2012 Aug;119(9):1141-1146. PMID: 22676722
Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Forns J, Lertxundi N, Aranbarri A, Murcia M, Gascon M, Martinez D, Grellier J, Lertxundi A, Julvez J, Fano E, Goñi F, Grimalt JO, Ballester F, Sunyer J, Ibarluzea J. Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life. Environ Int.2012 May 8;45C:72-77. PMID: 22575806
Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze
Gascon M, Vrijheid M, Martínez D, Ballester F, Basterrechea M, Blarduni E, Esplugues A, Vizcaino E, Grimalt JO, Morales E, Sunyer J; on behalf of the Infancia y Medio Ambiente (Environment and Childhood) (INMA) project. Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze. Eur Respir J. 2012 May;39(5):1188-1196. PMID: 22075485
Prenatal Exposure to Mercury and Infant Neurodevelopment in a Multicenter Cohort in Spain: Study of Potential Modifiers
Llop S, Guxens M, Murcia M, Lertxundi A, Ramon R, Riaño I, Rebagliato M, Ibarluzea J, Tardon A, Sunyer J, Ballester F; on Behalf of the INMA Project. Prenatal Exposure to Mercury and Infant Neurodevelopment in a Multicenter Cohort in Spain: Study of Potential Modifiers. Am J Epidemiol. 2012 Mar 1;175(5):451-465.PMID: 22287639
Socioeconomic status and exposure to multiple environmental pollutants during pregnancy: evidence for environmental inequity?
Vrijheid M, Martinez D, Aguilera I, Ballester F, Basterrechea M, Esplugues A, Guxens M, Larrañaga M, Lertxundi A, Mendez M, Murcia M, Santa Marina L, Villanueva CM, Sunyer J. Socioeconomic status and exposure to multiple environmental pollutants during pregnancy: evidence for environmental inequity?.J Epidemiol Community Health. 2012 Feb;66(2):106-13. PMID: 20974841
Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts
Govarts E, Nieuwenhuijsen M, Schoeters G, Ballester F, Bloemen K, de Boer M, Chevrier C, Eggesbø M, Guxens M, Krämer U, Legler J, Martinez D, Palkovi?ová L, Patelarou E, Ranft U, Rautio A, Petersen MS, Slama R, Stigum H, Toft G, Trnovec T, Vandentorr. Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts. Environ Health Perspect. 2012 Feb;120(2):162-70. PMID: 21997443
Prenatal Exposure to Residential Air Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification Factors
Guxens M, Aguilera I, Ballester F, Estarlich M, Fernández-Somoano A, Lertxundi A, Lertxundi N, Mendez MA, Tardón A, Vrijheid M, Sunyer J. Prenatal Exposure to Residential Air Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification Factors. Environ Health Perspect. 2012 Jan;120(1):144-9. PMID: 21868304
European birth cohorts for environmental health research
Vrijheid M, Casas M, Bergström A, Carmichael A, Cordier S, Eggesbø M, Eller E, Fantini MP, Fernández MF, Fernández-Somoano A, Gehring U, Grazuleviciene R, Hohmann C, Karvonen AM, Keil T, Kogevinas M, Koppen G, Krämer U, Kuehni CE, Magnus P, Majewska. European birth cohorts for environmental health research. Environ Health Perspect. 2012 Jan;120(1):29-37. PMID: 21878421
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