Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Trihalomethane and haloacetic acid concentrations in drinking water and their estimated intake during pregnancy in the INMA cohort (Guipúzcoa, Spain)
Santa Marina L, Ayerdi M, Lertxundi A, Basterretxea M, Goñi F, Iñaki Alvare J, Arranz L, Blarduni E, María Ibarluzea J. Trihalomethane and haloacetic acid concentrations in drinking water and their estimated intake during pregnancy in the INMA cohort (Guipúzcoa, Spain). Gac Sanit. 2010 Jul-Aug;24(4):321-8. Spanish. PMID: 20447740
Air quality assessment in urban areas of Gipuzkoa (Spain)
Lertxundi A, Martinez MD, Ayerdi M, Alvarez J, María Ibarluzea J. Air quality assessment in urban areas of Gipuzkoa (Spain). Gac Sanit. 2010 May-Jun;24(3):187-92. PMID: 20207046
Iodine intake and maternal thyroid function during pregnancy
Rebagliato M, Murcia M, Espada M, ‘Alvarez-Pedrerol M, Bolúmar F, Vioque J, Basterrechea M, Blarduni E, Ramón R, Guxens M, Foradada CM, Ballester F, Ibarluzea J, Sunyer J. Iodine intake and maternal thyroid function during pregnancy. Epidemiology.2010 Jan;21(1):62-9. PMID: 19940773
Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy
Alvarez-Pedrerol M, Guxens M, Ibarluzea J, Rebagliato M, Rodriguez A, Espada M, Goñi F, Basterrechea M, Sunyer J. Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy. Environ Sci Technol. 2009 Oct 15;43(20):7909-7915. PMID: 19921913
The Spanish Environment and Childhood Research Network (INMA study)
Fernandez MF, Sunyer J, Grimalt J, Rebagliato M, Ballester F, Ibarluzea J, Ribas-Fitó N, Tardon A, Fernandez-Patier R, Torrent M, Olea N. The Spanish Environment and Childhood Research Network (INMA study). Int J Hyg Environ Health. 2007;210(3-4):491-3. Epub 2007 Feb 22. PMID: 17320477
Air pollutant exposure during pregnancy and fetal and early childhood development. Research protocol of the INMA (Childhood and Environment Project)
Esplugues A, Fernández-Patier R, Aguilera I, Iñíguez C, García Dos Santos S, Aguirre Alfaro A, Lacasaña M, Estarlich M, Grimalt JO, Fernández M, Rebagliato M, Sala M, Tardón A, Torrent M, Martínez MD, Ribas-Fitó N, Sunyer J, Ballester F. Air pollutant exposure during pregnancy and fetal and early childhood development. Research protocol of the INMA (Childhood and Environment Project). Gac Sanit. 2007;21(2):162-71. Spanish. PMID: 17419934
Efectos de la exposición prenatal a contaminantes ambientales y de la dieta materna en el neurodesarrollo. La Red de investigación ‘Infancia y Medio Ambiente’ (Red INMA)
Rebagliato M, Ballester F, Ramon RM, Marco A. The effects of prenatal exposure to environmental pollutants and the mother’s diet on neurodevelopment. The ‘Infancy and Environment’ Research Network (INMA Network). Rev Neurol. 2007 21;44 Suppl 3:S15-8. Spanish. PMID: 17523104
Measurement of drinking water contaminants and water use activities during pregnancy in a cohort study in Spain
Villanueva CM, Grimalt JO, Ballester F, Ibarluzea J, Sala M, Tardón A, Romero-Aliaga E, Fernández M, Ribas-Fitó N, Kogevinas M. Measurement of drinking water contaminants and water use activities during pregnancy in a cohort study in Spain. Gac Sanit. 2006;20 Suppl 3:1-9. Spanish. PMID: 17433195
Child health and the environment: the INMA Spanish Study
Ribas-Fitó N, Ramón R, Ballester F, Grimalt J, Marco A, Olea N, Posada M, Rebagliato M, Tardón A, Torrent M, Sunyer J. Child health and the environment: the INMA Spanish Study. Paediatr Perinat Epidemiol. 2006;20(5):403-10. PMID: 16911019
The Environment and Childhood Research Network (“INMA” network): study protocol
Ramón R, Ballester F, Rebagliato M, Ribas N, Torrent M, Fernández M, Sala M, Tardón A, Marco A, Posada M, Grimalt J, Sunyer J; Red INMA. The Environment and Childhood Research Network (“INMA” network): study protocol.Rev Esp Salud Publica. 2005 Mar-Apr;79(2):203-20. Spanish. PMID: 15913055
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