Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Exposure to brominated flame retardants, perfluorinated compounds, phthalates and phenols in European birth cohorts: ENRIECO evaluation, first human biomonitoring results, and recommendations
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Estudio de la evolución de la exposición a plomo en la población infantil española en los últimos 20 años. ¿Un ejemplo no reconocido de ‘salud en todas las políticas’?
Llop S, Porta M, Martinez MD, Aguinagalde X, Fernández MF, Fernández-Somoano A, Casas M, Vrijheid M, Ayerdi M, Tardón A, Ballester F. Estudio de la evolución de la exposición a plomo en la población infantil española en los últimos 20 años. ¿Un ejemplo no reconocido de ‘salud en todas las políticas’?. Gac Sanit. 2013 Mar-Apr;27(2):149-55. Spanish. PMID: 22503157
Thyroxine Levels During Pregnancy in Healthy Women and Early Child Neurodevelopment
Julvez J, Alvarez-Pedrerol M, Rebagliato M, Murcia M, Forns J, Garcia-Esteban R, Lertxundi N, Espada M, Tardón A, Riaño Galán I, Sunyer J. Thyroxine Levels During Pregnancy in Healthy Women and Early Child Neurodevelopment. Epidemiology. 2013 Jan;24(1):150-157. PMID: 23232616
Maternal Prepregnancy Obesity is an Independent Risk Factor for Frequent Wheezing in Infants by Age 14 Months
Guerra S, Sartini C, Mendez M, Morales E, Guxens M, Basterrechea M, Arranz L, Sunyer J. Maternal Prepregnancy Obesity is an Independent Risk Factor for Frequent Wheezing in Infants by Age 14 Months. Paediatr Perinat Epidemiol. 2013 Jan;27(1):100-108. PMID: 23215717
Compuestos orgánicos persistentes y metales pesados en sangre y efectos en el desarrollo neuropsicológico de la primera infancia en las cohortes de madres-niños INMA (INfancia y Medio Ambiente)
Aritz Aranbarri Paredes, Eduardo Fano Ardanaz, Sabrina Llop Pérez, Rosa Ramón Bonache, Mario Murcia Hinarejos, Mònica Guxens Junyent, Nerea Lertxundi Iribar y Jesús Ibarluzea Maurolagoitia. Compuestos orgánicos persistentes y metales pesados en sangre y efectos en el desarrollo neuropsicológico de la primera infancia en las cohortes de madres-niños INMA (INfancia y Medio Ambiente). Rev. salud ambient. 2012;12(1):3-13.
Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls in placentas from the Spanish INMA birth cohort study
Fernandez MF, Parera J, Arrebola JP, Marina LS, Vrijheid M, Llop S, Abalos M, Tardon A, Castaño A, Abad E, Olea N. Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls in placentas from the Spanish INMA birth cohort study. Sci Total Environ. 2012 Dec 15;441:49-56. PMID: 23134768
Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants
Gascon M, Fort M, Martinez D, Carsin AE, Forns J, Grimalt JO, Santa Marina L, Lertxundi N, Sunyer J, Vrijheid M. Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants. Environ Health Perspect.2012 Dec;120(12):1760-5. PMID: 23052368
Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development
Morales E, Guxens M, Llop S, Rodríguez-Bernal CL, Tardón A, Riaño I, Ibarluzea J, Lertxundi N, Espada M, Rodriguez A, Sunyer J; on behalf of the INMA Project. Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development. Pediatrics. 2012 Oct;130(4):e913-e920. PMID: 22987876
Surrounding Greenness and Pregnancy Outcomes in Four Spanish Birth Cohorts
Dadvand P, Sunyer J, Basagaña X, Ballester F, Lertxundi A, Fernández-Somoano A, Estarlich M, Garcia-Esteban R, Mendez MA, Nieuwenhuijsen MJ. Surrounding Greenness and Pregnancy Outcomes in Four Spanish Birth Cohorts. Environ Health Perspect. 2012 Oct;120(10):1481-7. PMID: 22899599
Prevalence of exposure to occupational risks during pregnancy in Spain
García AM, González-Galarzo MC, Ronda E, Ballester F, Estarlich M, Guxens M, Lertxundia A, Martinez-Argüelles B, Marina LS, Tardón A, Vrijheid M. Prevalence of exposure to occupational risks during pregnancy in Spain. Int J Public Health. 2012 Oct;57(5):817-26. PMID: 22760548
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