Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study
Aurrekoetxea JJ, Murcia M, Rebagliato M, López MJ, Castilla AM, Santa-Marina L, Guxens M, Fernández-Somoano A, Espada M, Lertxundi A, Tardón A, Ballester F. Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study. BMJ Open. 2013 Jan 24;3(1).
Prenatal and postnatal residential usage of insecticides in a multicenter birth cohort in Spain
Llop S, Casas L, Santa Marina L, Estarlich M, Fernández-Somoano A, Esplugues A, Jimenez A, Zock JP, Tardón A, Marco A, Ballester F. Prenatal and postnatal residential usage of insecticides in a multicenter birth cohort in Spain. Sci Total Environ. 2013 Feb 15;445-446:273-80. PMID: 23337604
Environmental exposure assessment in European birth cohorts: results from the ENRIECO project
Gehring U, Casas M, Brunekreef B, Bergström A, Bonde JP, Botton J, Chévrier C, Cordier S, Heinrich J, Hohmann C, Keil T, Sunyer J, Tischer CG, Toft G, Wickman M, Vrijheid M, Nieuwenhuijsen M. Environmental exposure assessment in European birth cohorts: results from the ENRIECO project. Environ Health. 2013 Jan 23;12:8. PMID: 23343014
Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies.
Casas M, Chatzi L, Carsin AE, Amiano P, Guxens M, Kogevinas M, Koutra K, Lertxundi N, Murcia M, Rebagliato M, Riaño I, Rodríguez-Bernal CL, Roumeliotaki T, Sunyer J, Mendez M, Vrijheid M. Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies. Int J Epidemiol. 2013 Apr;42(2):506-17. PMID: 23569191
Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy
Morales E, Gascon M, Martinez D, Casas M, Ballester F, Rodríguez-Bernal CL, Ibarluzea J, Marina LS, Espada M, Goñi F, Vizcaino E, Grimalt JO, Sunyer J; on behalf of the INMA Project. Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy. Environ Int.2013 Jul;57-58:34-41. PMID: 23651836
Pooling birth cohorts in allergy and asthma: European Union-funded initiatives – a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper
Bousquet J, Anto J, Sunyer J, Nieuwenhuijsen M, Vrijheid M, Keil T; MeDALL Study Group; CHICOS Study Group; ENRIECO Study Group; GA²LEN Study Group. Pooling birth cohorts in allergy and asthma: European Union-funded initiatives – a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper. Int Arch Allergy Immunol. 2013;161(1):1-10. PMID: 23258290
Male specific association between xenoestrogen levels in placenta and birthweight
Vilahur N, Molina-Molina JM, Bustamante M, Murcia M, Arrebola JP, Ballester F, Mendez MA, Garcia-Esteban R, Guxens M, Santa Marina L, Tardón A, Sunyer J, Olea N, Fernandez MF. Male specific association between xenoestrogen levels in placenta and birthweight. Environ Int. 2013 Jan;51:174-81. PMID: 23262415
Current dietary exposure to mercury during pregnancy and childhood, and public health recommendations
Llop S, Ibarlucea J, Sunyer J, Ballester F. Current dietary exposure to mercury during pregnancy and childhood, and public health recommendations. Gac Sanit. 2013 May-Jun;27(3):273-8. Spanish.PMID: 23122516
Early Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study
Aguilera I, Pedersen M, Garcia-Esteban R, Ballester F, Basterrechea M, Esplugues A, Fernández-Somoano A, Lertxundi A, Tardón A, Sunyer J. Early Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study. Environ Health Perspect. 2013 Mar;121(3):387-92.PMID: 23221880
Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children
Gascon M, Verner MA, Guxens M, Grimalt JO, Forns J, Ibarluzea J, Lertxundi N, Ballester F, Llop S, Haddad S, Sunyer J, Vrijheid M. Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children. Neurotoxicology. 2013 Jan;34:9-15. PMID: 23085522
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