Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis
Gascon M, Sunyer J, Casas M, Martínez D, Ballester F, Basterrechea M, Bonde JP, Chatzi L, Chevrier C, Eggesbø M, Esplugues A, Govarts E, Hannu K, Ibarluzea J, Kasper-Sonnenberg M, Klümper C, Koppen G, Nieuwenhuijsen MJ, Palkovicova L, Pelé F, Polder. Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis. Epidemiology. 2014 Jul;25(4):544-53. PMID: 24776790
Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children
Sonnenschein-van der Voort AM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, Basterrechea M, Bisgaard H, Chatzi L, Corpeleijn E, Correia S, Craig LC, Devereux G, Dogaru C, Dostal M, Duchen K, Eggesbø M, van der Ent CK, Fantini MP. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014 May;133(5):1317-29. PMID: 24529685
Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies
Leventakou V, Roumeliotaki T, Martinez D, Barros H, Brantsaeter AL, Casas M, Charles MA, Cordier S, Eggesbø M, van Eijsden M, Forastiere F, Gehring U, Govarts E, Halldórsson TI, Hanke W, Haugen M, Heppe DH, Heude B, Inskip HM, Jaddoe VW, Jansen M, Ke. Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies. Am J Clin Nutr. 2014 Mar;99(3):506-16. PMID: 24335057
The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies
Hohmann C, Pinart M, Tischer C, Gehring U, Heinrich J, Kull I, Melén E, Smit HA, Torrent M, Wijga AH, Wickman M, Bachert C, Lødrup Carlsen KC, Carlsen KH, Bindslev-Jensen C, Eller E, Esplugues A, Fantini MP, Annesi-Maesano I, Momas I, Porta D, Vassil. The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies. Int Arch Allergy Immunol. 2014;163(3):215-24. PMID: 24642608
Air Polycyclic Aromatic Hydrocarbons (PAHs) associated with PM2.5 in a North Cantabric coast urban environment
Villar-Vidal M, Lertxundi A, Martinez López de Dicastillo MD, Alvarez JI, Santa Marina L, Ayerdi M, Basterrechea M, Ibarluzea J. Air Polycyclic Aromatic Hydrocarbons (PAHs) associated with PM2.5 in a North Cantabric coast urban environment. Chemosphere. 2014 Mar;99:233-8. PMID: 24331032
Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project
Macintyre EA, Gehring U, Mölter A, Fuertes E, Klümper C, Krämer U, Quass U, Hoffmann B, Gascon M, Brunekreef B, Koppelman GH, Beelen R, Hoek G, Birk M, de Jongste JC, Smit H, Cyrys J, Gruzieva O, Korek M, Bergström A, Agius RM, de Vocht F, Simpson A. Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project. Environ Health Perspect. 2014 Jan;122(1):107-13. PMID: 24149084
Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy
Valvi D, Mendez MA, Garcia-Esteban R, Ballester F, Ibarluzea J, Goñi F, Grimalt JO, Llop S, Marina LS, Vizcaino E, Sunyer J, Vrijheid M. Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy. Obesity (Silver Spring). 2014 Feb;22(2):488-96. PMID: 23963708
Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes
Slama R, Ballester F, Casas M, Cordier S, Eggesbø M, Iniguez C, Nieuwenhuijsen M, Philippat C, Rey S, Vandentorren S, Vrijheid M. Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes. Epidemiol Rev. 2014;36(1):148-64. PMID: 24363355
Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain
Basterrechea M, Lertxundi A, Iñiguez C, Mendez M, Murcia M, Mozo I, Goñi F, Grimalt J, Fernández M, Guxens M; INMA project. Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain. Sci Total Environ. 2014 Jan 1;466-467:770-6. PMID: 23973543
Factors associated with second-hand smoke exposure in non-smoking pregnant women in Spain: Self-reported exposure and urinary cotinine levels
Aurrekoetxea JJ, Murcia M, Rebagliato M, Fernández-Somoano A, Castilla AM, Guxens M, López MJ, Lertxundi A, Espada M, Tardón A, Ballester F, Santa-Marina L. Factors associated with second-hand smoke exposure in non-smoking pregnant women in Spain: Self-reported exposure and urinary cotinine levels. Sci Total Environ. 2014 Feb 1;470-471:1189-96. PMID: 24246942
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