Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Pre- and post-natal exposure to tobacco smoke and respiratory outcomes during the first year
Fuentes-Leonarte V, Estarlich M, Ballester F, Murcia M, Esplugues A, Aurrekoetxea JJ, Basterrechea M, Fernández-Somoano A, Morales E, Gascón M, Tardón A, Rebagliato M. Pre- and post-natal exposure to tobacco smoke and respiratory outcomes during the first year.Indoor Air. 2015 Feb;25(1):4-12. PMID: 24810295
Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age
Morales E, Garcia-Esteban R, Asensio de la Cruz O, Basterrechea M, Lertxundi A, Martinez López de Dicastillo MD, Zabaleta C, Sunyer J. Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age. Thorax. 2015 Jan;70(1):64-73. PMID: 25331281
Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers
Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, Chatzi L, Chevrier C, Eggesbø M, Fernandez MF, Govarts E, Guxens M, Grimalt JO, Hertz-Picciotto I, Iszatt N, Kasper-Sonnenberg M, Kiviranta H, Kogevinas M, Palkovicova L,. Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers. Environ Int. 2015 Jan;74:23-31. PMID: 25314142
Postnatal weight growth and trihalomethane exposure during pregnancy
Botton J, Kogevinas M, Gracia-Lavedan E, Patelarou E, Roumeliotaki T, Iñiguez C, Santa Marina L, Ibarluzea J, Ballester F, Mendez MA, Chatzi L, Sunyer J, Villanueva CM. Postnatal weight growth and trihalomethane exposure during pregnancy. Environ Res. 2015 Jan;136:280-8. PMID: 25460647
Folic Acid supplements during pregnancy and child psychomotor development after the first year of life
Valera-Gran D, García de la Hera M, Navarrete-Muñoz EM, Fernandez-Somoano A, Tardón A, Julvez J, Forns J, Lertxundi N, Ibarluzea JM, Murcia M, Rebagliato M, Vioque J; Infancia y Medio Ambiente (INMA) Project. Folic Acid supplements during pregnancy and child psychomotor development after the first year of life. JAMA Pediatr. 2014 Nov 3;168(11):e142611. doi:10.1001/jamapediatrics.2014.2611. Epub 2014 Nov 3. PMID: 25365251
In utero exposure to mixtures of xenoestrogens and child neuropsychological development
Vilahur N, Fernández MF, Bustamante M, Ramos R, Forns J, Ballester F, Murcia M, Riaño I, Ibarluzea J, Olea N, Sunyer J. In utero exposure to mixtures of xenoestrogens and child neuropsychological development. Environ Res. 2014 Jul 31;134C:98-104. PMID: 25086706
Family context assessment in a public health study
Velasco D, Sánchez de Miguel M, Egurza M, Arranz E, Aranbarri A, Fano E, Ibarluzea J. Family context assessment in a public health study. Gac Sanit. 2014 Sep-Oct;28(5):356-62. PMID: 24929614
Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta
Vilahur N, Bustamante M, Byun HM, Fernandez MF, Santa Marina L, Basterrechea M, Ballester F, Murcia M, Tardón A, Fernández-Somoano A, Estivill X, Olea N, Sunyer J, Baccarelli AA. Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta. Environ Int.2014 Jun 27;71C:81-87. PMID: 24980756
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Kl. Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts.E pidemiology. 2014 Sep;25(5):636-647. PMID: 25036432
The human early-life exposome (HELIX): project rationale and design
Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražul. The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect. 2014 Jun;122(6):535-44. PMID: 24610234
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