Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
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Annoyance Caused by Noise and Air Pollution during Pregnancy: Associated Factors and Correlation with Outdoor NO2 and Benzene Estimations
Fernández-Somoano A, Llop S, Aguilera I, Tamayo-Uria I, Martínez MD, Foraster M, Ballester F, Tardón A. Annoyance Caused by Noise and Air Pollution during Pregnancy: Associated Factors and Correlation with Outdoor NO2 and Benzene Estimations. Int J Environ Res Public Health. 2015 Jun 18;12(6):7044-58. PMID: 26095869
Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood
Morales E, Julvez J, Torrent M, Ballester F, Rodríguez-Bernal CL, Andiarena A, Vegas O, Castilla AM, Rodriguez-Dehli C, Tardón A, Sunyer J. Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology. 2015 Jul;26(4):458-65. PMID: 25867115
Maternal complications in pregnancy and wheezing in early childhood: A pooled analysis of 14 birth cohorts
Zugna D, Galassi C, Annesi-Maesano I, Baïz N, Barros H, Basterrechea M, Correia S, Duijts L, Esplugues A, Fantini MP, Forastiere F, Gascon M, Gori D, Inskip H, Larsen PS, Mommers M, Nybo Andersen AM, Penders J, Petersen MS, Pike K, Porta D, Sonnensch. Maternal complications in pregnancy and wheezing in early childhood: A pooled analysis of 14 birth cohorts. Int J Epidemiol. 2015 Feb;44(1):199-208 .PMID: 25626439
Maternal Thyroid Dysfunction during Gestation, Preterm Delivery, and Birthweight. The Infancia y Medio Ambiente Cohort, Spain
León G, Murcia M, Rebagliato M, Álvarez-Pedrerol M, Castilla AM, Basterrechea M, Iñiguez C, Fernández-Somoano A, Blarduni E, Foradada CM, Tardón A, Vioque J. Maternal Thyroid Dysfunction during Gestation, Preterm Delivery, and Birthweight. The Infancia y Medio Ambiente Cohort, Spain. Paediatr Perinat Epidemiol.2015; 29(2): 113-122. PMID: 25565408
Prenatal head growth and child neuropsychological development at age 14 months
Álamo-Junquera D, Sunyer J, Iñiguez C, Ballester F, Esteban RG, Forns J, Turner MC, Lertxundi A, Lertxundi N, Somoano AF, Dehli CR, Julvez J. Prenatal head growth and child neuropsychological development at age 14 months.Am J Obstet Gynecol. 2015; 212(5): 661.PMID: 25499263
Compliance of nutritional recommendations of Spanish pregnant women according to sociodemographic and lifestyle characteristics: a cohort study
Villar-Vidal M, Amiano P, Rodriguez-Bernal C, Santa Marina L, Mozo I, Vioque J, Navarrete-Muñoz EM, Romaguera D, Valvi D, Fernandez Samoano A, Tardon A, Ibarluzea J. Compliance of nutritional recommendations of Spanish pregnant women according to sociodemographic and lifestyle characteristics: a cohort study. Nutr Hosp. 2015 Apr 1;31(n04):1803-1812. PMID: 25795974
Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women
Llop S, Lopez-Espinosa MJ, Murcia M, Alvarez-Pedrerol M, Vioque J, Aguinagalde X, Julvez J, Aurrekoetxea JJ, Espada M, Santa-Marina L, Rebagliato M, Ballester F. Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women. Environ Res. 2015 Mar 4;138C:298-305. PMID: 25749125
Deficit of vitamin D in pregnancy and growth and overweight in the offspring
Morales E, Rodriguez A, Valvi D, Iñiguez C, Esplugues A, Vioque J, Marina LS, Jiménez A, Espada M, Dehli CR, Fernández-Somoano A, Vrijheid M, Sunyer J. Deficit of vitamin D in pregnancy and growth and overweight in the offspring. Int J Obes (Lond). 2015 Jan;39(1):61-8. PMID: 25189178
Prevalence of factors associated with the duration of exclusive breastfeeding during the first 6 months of life in the INMA birth cohort in Gipuzkoa
Oribe M, Lertxundi A, Basterrechea M, Begiristain H, Santa Marina L, Villar M, Dorronsoro M, Amiano P, Ibarluzea J. Prevalence of factors associated with the duration of exclusive breastfeeding during the first 6 months of life in the INMA birth cohort in Gipuzkoa. Gac Sanit. 2015 Jan-Feb;29(1):4-9. PMID: 25258325
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