Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol
Gallastegi M, Guxens M, Jiménez-Zabala A, Calvente I, Fernández M, Birks L, Struchen B, Vrijheid M, Estarlich M, Fernández MF, Torrent M, Ballester F, Aurrekoetxea JJ, Ibarluzea J, Guerra D, González J, Röösli M, Santa-Marina L. Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol. BMC Public Health. 2016 Feb 18;16(1):167. PMID: 26892951
Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project
Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, Almqvist C, Aranbarri A, Beelen R, Badaloni C, Cesaroni G, de Nazelle A, Estarlich M, Forastiere F, Forns J, Gehring U, Ibarluzea J, Jaddoe VW, Korek M, Lichtenstein P, Ni. Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project. Environ Health Perspect. 2016 Jan;2016(1):133-40. PMID: 26068947
Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain)
Lopez-Espinosa MJ, Murcia M, Iñiguez C, Vizcaino E, Costa O, Fernández-Somoano A, Basterrechea M, Lertxundi A, Guxens M, Gascon M, Goñi-Irigoyen F, Grimalt JO, Tardón A, Ballester F. Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain). Environ Health Perspect. 2016 Jan;2016(1):157-63. PMID: 26058084
Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study
Navarrete-Muñoz EM, Valera-Gran D, García de la Hera M, Gimenez-Monzo D, Morales E, Julvez J, Riaño I, Tardón A, Ibarluzea J, Santa-Marina L, Murcia M, Rebagliato M, Vioque J; INMA Project. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open. 2015 Nov 24;5(11):e009202. doi: 10.1136/bmjopen-2015-009202. PMID: 26603248
Water hardness and eczema at 1 and 4y of age in the INMA birth cohort
Font-Ribera L, Gracia-Lavedan E, Esplugues A, Ballester F, Jiménez Zabala A, Santa Marina L, Fernández-Somoano A, Sunyer J, Villanueva CM. Water hardness and eczema at 1 and 4y of age in the INMA birth cohort. Environ Res. 2015 Oct;142:579-85.P MID: 26298601
Transfer of perfluoroalkyl substances from mother to fetus in a Spanish birth cohort
Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Basterrechea M, Grimalt JO, Jiménez AM, Kraus T, Schettgen T, Sunyer J, Vrijheid M. Transfer of perfluoroalkyl substances from mother to fetus in a Spanish birth cohort. Environ Res.2015 Oct;142:471-8. PMID: 26257032
Mother’s education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts
Ruiz M, Goldblatt P, Morrison J, Kukla L, Švancara J, Riitta-Järvelin M, Taanila A, Saurel-Cubizolles MJ, Lioret S, Bakoula C, Veltsista A, Porta D, Forastiere F, van Eijsden M, Vrijkotte TG, Eggesbø M, White RA, Barros H, Correia S, Vrijheid M, Torr. Mother’s education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts. J Epidemiol Community Health. 2015 Sep;69(9):826-33. PMID: 25911693
Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes
Rodriguez A, García-Esteban R, Basterretxea M, Lertxundi A, Rodríguez-Bernal C, Iñiguez C, Rodriguez-Dehli C, Tardón A, Espada M, Sunyer J, Morales E. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG. 2015 Nov;122(12):1695-704. PMID: 25208685
Exploring educational disparities in risk of preterm delivery: a comparative study of 12 European birth cohorts
Poulsen G, Strandberg-Larsen K, Mortensen L, Barros H, Cordier S, Correia S, Danileviciute A, van Eijsden M, Fernández-Somoano A, Gehring U, Grazuleviciene R, Hafkamp-de Groen E, Henriksen TB, Jensen MS, Larrañaga I, Magnus P, Pickett K, Raat H, Rich. Exploring educational disparities in risk of preterm delivery: a comparative study of 12 European birth cohorts. Paediatr Perinat Epidemiol. 2015 May;29(3):172-83. PMID: 25808200
Exposure to fine particle matter, nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15months of age
Lertxundi A, Baccini M, Lertxundi N, Fano E, Aranbarri A, Martínez MD, Ayerdi M, Álvarez J, Santa-Marina L, Dorronsoro M, Ibarluzea J. Exposure to fine particle matter, nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15months of age. Environ Int. 2015 Jul;80:33-40. PMID: 25881275
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