Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
Morales E, Vilahur N, Salas LA, Motta V, Fernandez MF, Murcia M, Llop S, Tardon A, Fernandez-Tardon G, Santa-Marina L, Gallastegui M, Bollati V, Estivill X, Olea N, Sunyer J, Bustamante M. Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. Int J Epidemiol. 2016 Oct;45(5):1644-1655. PMID: 27591263
Drinking water disinfection by products, genetic polymorphisms, and birth outcomes in a European mother-child cohort study
Kogevinas M, Bustamante M, Gracia-Lavedán E, Ballester F, Cordier S, Costet N, Espinosa A, Grazuleviciene R, Danileviciute A, Ibarluzea J, Karadanelli M, Krasner S, Patelarou E, Stephanou E, Tardón A, Toledano MB, Wright J, Villanueva CM, Nieuwenhuij. Drinking water disinfection by products, genetic polymorphisms, and birth outcomes in a European mother-child cohort study. Epidemiology. 2016 Nov;27(6):903-11.PMID: 27468006
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražuleviien R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen A. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environ Health Perspect. 2016 Nov;124(11):1785-1793. PMID: 27152464
La biomonitorización de sustancias tóxicas en muestras biológicas de población general
Ibarluzea J, Aurrekoetxea JJ, Porta M, Sunyer J, Ballester F. La biomonitorización de sustancias tóxicas en muestras biológicas de población general. Gac Sanit. 2016 Nov;30 Suppl 1:45-54.PMID: 27132480
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy
Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, Postma DS, Valenta R, Wickman M, Cambon-Thomsen A, Haahtela T, Lambrecht BN, Lodrup Carlsen KC, Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Fo. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy. Allergy. 2016 Nov;71(11):1513-1525. PMID: 26970340
Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study
Fernández-Barrés S, Romaguera D, Valvi D, Martínez D, Vioque J, Navarrete-Muñoz EM, Amiano P, Gonzalez-Palacios S, Guxens M, Pereda E, Riaño I, Tardón A, Iñiguez C, Arija V, Sunyer J, Vrijheid M; INMA Project. Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study. Pediatr Obes. 2016 Dec;11(6):491-499. PMID: 26763767
Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe
Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Antipkin Y, Saurel-Cubizolles MJ, Lioret S, Vrijheid M, Torrent M, Iñiguez C, Larrañaga I, Bakoula C, Veltsista A, van Eijsden M, Vrijkotte TG, Andrýsková L, Dušek L, Barros H, Cor. Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe. Paediatr Perinat Epidemiol. 2016 May;30(3):274-84. PMID: 26945670
Prenatal mercury exposure and birth outcomes
Murcia M, Ballester F, Enning AM, Iñiguez C, Valvi D, Basterrechea M, Rebagliato M, Vioque J, Maruri M, Tardon A, Riaño-Galán I, Vrijheid M, Llop S. Prenatal mercury exposure and birth outcomes. Environ Res. 2016 Jul 20;151:11-20.PMID: 27448728
The association between passive and active tobacco smoke exposure and child weight status among Spanish children
Robinson O, Martínez D, Aurrekoetxea JJ, Estarlich M, Somoano AF, Íñiguez C, Santa-Marina L, Tardón A, Torrent M, Sunyer J, Valvi D, Vrijheid M. The association between passive and active tobacco smoke exposure and child weight status among Spanish children. Obesity (Silver Spring). 2016 Aug;24(8):1767-77. PMID: 27367931
Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort
Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Martinez D, Ibarluzea J, Santa-Marina L, Schettgen T, Vioque J, Sunyer J, Vrijheid M. Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort. Environ Int. 2016 Jul-Aug;92-93:357-65.PMID: 27132161
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