Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

330 Results

Nutrition -
Reproductive health -


Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts

Strandberg-Larsen K, Poulsen G, Bech BH, Chatzi L, Cordier S, Dale MTG, Fernandez M, Henriksen TB, Jaddoe VW, Kogevinas M, Kruithof CJ, Lindhard MS, Magnus P, Nohr EA, Richiardi L, Rodriguez-Bernal CL, Rouget F, Rusconi F, Vrijheid M, Andersen AN. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. Eur J Epidemiol. 2017 Sep;32(9):751-764. PMID: 29027084


Cardiometabolic -
No persistent organic compounds -


Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Martinez D, Romaguera D, Fernández-Barrés S, Santa-Marina L, Basterretxea M, Schettgen T, Valvi D, Vioque J, Sunyer J, Vrijheid M. Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study. Environ Health Perspect. 2017 Sep 20;125(9):097018. PMID: 28934720


Neurodevelopment -


Neuropsychological Assessment at Preschool Age: Adaptation and Validation of the McCarthy Scales of Children’s Abilities to 4 Year-old Basque-speaking Children

Andiarena A, Balluerka N, Gorostiaga A, Ibarluzea J. Neuropsychological Assessment at Preschool Age: Adaptation and Validation of the McCarthy Scales of Children’s Abilities to 4 Year-old Basque-speaking Children. Span J Psychol. 2017 Oct 23;20:E49. PMID: 29056101


Persistent organic compounds -
Pregnancy complications -


Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts

Matilla-Santander N, Valvi D, Lopez-Espinosa MJ, Manzano-Salgado CB, Ballester F, Ibarluzea J, Santa-Marina L, Schettgen T, Guxens M, Sunyer J, Vrijheid M. Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts. Environ Health Perspect. 2017 Nov 13;125(11):117004. PMID: 29135438


Built environment and Greeness -
Respiratory health and atopy -


Urban green and grey space in relation to respiratory health in children

Tischer C, Gascon M, Fernández-Somoano A, Tardón A, Lertxundi Materola A, Ibarluzea J, Ferrero A, Estarlich M, Cirach M, Vrijheid M, Fuertes E, Dalmau-Bueno A, Nieuwenhuijsen MJ, Antó JM, Sunyer J, Dadvand P. Urban green and grey space in relation to respiratory health in children. Eur Respir J. 2017 Jun 22;49(6). PMID: 28642307


Respiratory health and atopy -


Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe

Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A, Bousquet J, Chatzi L, Fantini MP, Ferrero A, Gehring U, Gori D, Heinrich J, Keil T, Kull I, Lau S, Maier D, Momas I, Narduzzi S, Porta D, Ranciere F, Roumeliotaki T, Schikowski T, Smit HA, Standl M, Sunyer J, Wright J. Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017 Jul 3;3(3). PMID: 28845428


Nutrition -


Dietary intake of trans fatty acids in children aged 4-5 in Spain: the INMA cohort study

Scholz A, Gimenez-Monzo D, Navarrete-Muñoz EM, Garcia-de-la-Hera M, Fernandez-Somoano A, Tardon A, Santa Marina L, Irazabal A, Romaguera D, Guxens M, Julvez J, Llop S, Lopez-Espinosa MJ, Vioque J. Dietary Intake of Trans Fatty Acids in Children Aged 4-5 in Spain: The INMA Cohort Study. Nutrients. 2016 Oct 10;8(10). pii: E625. PMID: 27735864


General about the Project -


Environment and Brain Development: Challenges in the Global Context

Júlvez J, Paus T, Bellinger D, Eskenazi B, Tiemeier H, Pearce N, Ritz B, White T, Ramchandani P, Gispert JD, Desrivières S, Brouwer R, Boucher O, Alemany S, López-Vicente M, Suades-González E, Forns J, Grandjean P, Sunyer J. Environment and Brain Development: Challenges in the Global Context. Neuroepidemiology. 2016;46(2):79-82. PMID: 26684467


Drugs -
Neurodevelopment -


Acetaminophen Use in Pregnancy and Neurodevelopment: Attention Function and Autism Spectrum Symptoms

Avella-Garcia CB, Julvez J, Fortuny J, Rebordosa C, García-Esteban R, Galán IR, Tardón A, Rodríguez-Bernal CL, Iñiguez C, Andiarena A, Santa-Marina L, Sunyer J. Acetaminophen Use in Pregnancy and Neurodevelopment: Attention Function and Autism Spectrum Symptoms. Int J Epidemiol. 2016 Dec 1;45(6):1987-1996. PMID: 27353198


Intrauterine growth -
Metabolomics -
Reproductive health -


Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study

Maitre L, Villanueva CM, Lewis MR, Ibarluzea J, Santa-Marina L, Vrijheid M, Sunyer J, Coen M, Toledano MB. Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study. BMC Med.2016 Nov 4;14(1):177. PMID: 27814705


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