Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

330 Results

Metals -
Nutrition -


Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain

Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García de la Hera M, Sunyer J, Casas M, Riaño-Galán I, Tardón A, Llop S, Amorós R, Amiano P, Bilbao JR, Karagas MR, Meharg AA. Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environ Res. 2017 Nov;159:69-75. PMID: 28772151


Persistent organic compounds -
Reproductive health -


Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort

Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Martinez D, Costa O, Santa-Marina L, Pereda-Pereda E, Schettgen T, Sunyer J, Vrijheid M. Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort. Environ Int. 2017 Nov;108:278-284. PMID: 28917208


Electromagnetics field -


Exposure to extremely low and intermediate-frequency magnetic and electric fields among children from the INMA-Gipuzkoa cohort

Gallastegi M, Jiménez-Zabala A, Santa-Marina L, Aurrekoetxea JJ, Ayerdi M, Ibarluzea J, Kromhout H, González J, Huss A. Exposure to extremely low and intermediate-frequency magnetic and electric fields among children from the INMA-Gipuzkoa cohort. Environ Res. 2017 Aug;157:190-197. PMID: 28575784


Air pollution -
Epigenetics -


Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort

Clemente DBP, Casas M, Janssen BG, Lertxundi A, Santa-Marina L, Iñiguez C, Llop S, Sunyer J, Guxens M, Nawrot TS, Vrijheid M. Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort. Environ Res. 2017 Aug;157:96-102. PMID: 28535425


Neurodevelopment -
Stress -


Evening salivary cortisol and alpha-amylase at 14months and neurodevelopment at 4years: Sex differences

Andiarena A, Balluerka N, Murcia M, Ibarluzea J, Glover V, Vegas O. Evening salivary cortisol and alpha-amylase at 14months and neurodevelopment at 4years: Sex differences. Horm Behav. 2017 Aug;94:135-144. PMID: 28750755


Postnatal growth and Obesity -


Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642. PMID: 29029897


Air pollution -
Meteorology -
Reproductive health -


The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Giorgis-Allemand L, Pedersen M, Bernard C, Aguilera I, Beelen RM, Chatzi L, Cirach M, Danileviciute A, Dedele A, van Eijsden M, Estarlich M, Fernández-Somoano A, Fernández MF, Forastiere F, Gehring U, Grazuleviciene R, Gruzieva O, Heude B, Hoek G, de. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth. Am J Epidemiol. 2017 Feb 15;185(4):247-258. PMID: 28087514


Respiratory health and atopy -


Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Anto JM, Bousquet J, Akdis M, Auffray C, Keil T, Momas I, Postma DS, Valenta R, Wickman M, Cambon-Thomsen A, Haahtela T, Lambrecht BN, Lodrup Carlsen KC, Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Fo. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017 Feb;139(2):388-399. PMID: 28183433


Hormonal disturbances -
Persistent organic compounds -


Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies

Ballesteros V, Costa O, Iñiguez C, Fletcher T, Ballester F, Lopez-Espinosa MJ. Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies. Environ Int. 2017 Feb;99:15-28. PMID: 27884404


Family factors -
Neurodevelopment -


Family context and cognitive development in early childhood: A longitudinal study

Florencia Belén Barretoa, Manuel Sánchez de Miguela, Jesús Ibarluzea, Ainara Andiarena, Enrique Arranz. Family context and cognitive development in early childhood: A longitudinal study. Intelligence 65 (2017) 11–22.


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