Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
-
Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
-
Collaborating Entities:
Buscador
Association between breastfeeding duration and cognitive development, autistic traits and ADHD symptoms: a multicenter study in Spain
Boucher O, Julvez J, Guxens M, Arranz E, Ibarluzea J, Sánchez de Miguel M, Fernández-Somoano A, Tardon A, Rebagliato M, Garcia-Esteban R, O’Connor G, Ballester F, Sunyer J. Association between breastfeeding duration and cognitive development, autistic traits and ADHD symptoms: a multicenter study in Spain. Pediatr Res. 2017 Mar;81(3):434-442. PMID: 27846197
Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study
Valera-Gran D, Navarrete-Muñoz EM, Garcia de la Hera M, Fernández-Somoano A, Tardón A, Ibarluzea J, Balluerka N, Murcia M, González-Safont L, Romaguera D, Julvez J, Vioque J; INMA Project. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study. Am J Clin Nutr. 2017 Sep;106(3):878-887. PMID: 28724645
Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption
Llop S, Ballester F, Murcia M, Forns J, Tardon A, Andiarena A, Vioque J, Ibarluzea J, Fernández-Somoano A, Sunyer J, Julvez J, Rebagliato M, Lopez-Espinosa MJ. Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption. Int J Epidemiol. 2017 Jun 1;46(3):827-838. PMID: 27864405
Are Early Physical Activity and Sedentary Behaviors Related to Working Memory at 7 and 14 Years of Age?
López-Vicente M, Garcia-Aymerich J, Torrent-Pallicer J, Forns J, Ibarluzea J, Lertxundi N, González L, Valera-Gran D, Torrent M, Dadvand P, Vrijheid M, Sunyer J. Are Early Physical Activity and Sedentary Behaviors Related to Working Memory at 7 and 14 Years of Age?. J Pediatr. 2017 Sep;188:35-41. PMID: 28688631
Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study
Casas M, Forns J, Martínez D, Guxens M, Fernandez-Somoano A, Ibarluzea J, Lertxundi N, Murcia M, Rebagliato M, Tardon A, Sunyer J, Vrijheid M. Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study. Pediatr Res. 2017 Oct;82(4):596-606. PMID: 28493861
Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts
Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, Cordier S, de Groot R, den Dekker HT, Duijts L, Eggesbø M, Pia Fantini M, Forastiere F, Gehring U, Gielen M, Gori D, Govarts E, Inskip HM, Iszatt N, Jansen M, Kelleher C, Mehegan J, Moltó-Puigmartí C, Mommers M, Oliveira A, Olsen SF, Pelé F, Pizzi C, Porta D, Richiardi L, Rifas-Shiman SL, Robinson SM, Schoeters G, Strøm M, Sunyer J, Thijs C, Vrijheid M, Vrijkotte TG, Wijga AH, Kogevinas M, Zeegers MP, Chatzi L. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol. 2017 Oct 1;46(5):1465-1477. PMID: 28338907
Urinary Arsenic Speciation in Children and Pregnant Women from Spain
Signes-Pastor AJ, Carey M, Vioque J, Navarrete-Muñoz EM, Rodríguez-Dehli C, Tardón A, Begoña-Zubero M, Santa-Marina L, Vrijheid M, Casas M, Llop S, Gonzalez-Palacios S, Meharg AA. Urinary Arsenic Speciation in Children and Pregnant Women from Spain. Expo Health. 2017;9(2):105-111. PMID: 28553665
Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts
Birks L, Guxens M, Papadopoulou E, Alexander J, Ballester F, Estarlich M, Gallastegi M, Ha M, Haugen M, Huss A, Kheifets L, Lim H, Olsen J, Santa-Marina L, Sudan M, Vermeulen R, Vrijkotte T, Cardis E, Vrijheid M. Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts. Environ Int. 2017 Jul;104:122-131. PMID: 28392066
Mother’s education and offspring asthma risk in 10 European cohort studies
Lewis KM, Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Zvinchuk O, Saurel-Cubizolles MJ, Lioret S, Annesi-Maesano I, Vrijheid M, Torrent M, Iniguez C, Larranaga I, Harskamp-van Ginkel MW, Vrijkotte TGM, Klanova J, Svancara J, Barross H, Correia S, Jarvelin MR, Taanila A, Ludvigsson J, Faresjo T, Marmot M, Pikhart H. Mother’s education and offspring asthma risk in 10 European cohort studies. Eur J Epidemiol. 2017 Sep;32(9):797-805. PMID: 28929268
Prenatal and postnatal exposure to NO(2) and child attentional function at 4-5years of age
Sentís A, Sunyer J, Dalmau-Bueno A, Andiarena A, Ballester F, Cirach M, Estarlich M, Fernández-Somoano A, Ibarluzea J, Íñiguez C, Lertxundi A, Tardón A, Nieuwenhuijsen M, Vrijheid M, Guxens M; INMA Project. Prenatal and postnatal exposure to NO(2) and child attentional function at 4-5years of age. Environ Int. 2017 Sep;106:170-177. PMID: 28689118
19 / 33