Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Comparison of urinary iodine levels in women of childbearing age during and after pregnancy
Castilla AM, Murcia M, Arrizabalaga JJ, Espada M, Julvez J, Basterrechea M, Alvarez-Pedrerol M, Estarlich M, Moreno E, Guxens M, Vioque J, Rebagliato M. Comparison of urinary iodine levels in women of childbearing age during and after pregnancy. Eur J Nutr. 2018 Aug;57(5):1807-1816. PMID: 28456846
Fluoride intake through consumption of water from municipal network in the INMA-Gipuzkoa cohort
Jiménez-Zabala A, Santa-Marina L, Otazua M, Ayerdi M, Galarza A, Gallastegi M, Ulibarrena E, Molinuevo A, Anabitarte A, Ibarluzea J. [Fluoride intake through consumption of water from municipal network in the INMA-Gipuzkoa cohort]. Gac Sanit. 2018 Sep – Oct;32(5):418-424. PMID: 28545738
Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe
Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, Gong T, Gehring U, Sørensen M, Standl M, Sugiri D, Almqvist C, Andiarena A, Badaloní C, Beelen R, Berdel D, Cesaroni G, Charles MA, Eriksen KT, Estarlich M, Fernandez MF, Forhan A, Jaddoe VWV, Korek M, Lichtenstein P, Lertxundi A, Lopez-Espinosa MJ, Markevych I, de Nazelle A, Raaschou-Nielsen O, Nieuwenhuijsen M, Pérez-Lobato R, Philippat C, Slama R, Tiesler CM, Verhulst FC, von Berg A, Vrijkotte T, Nybo Andersen AM, Heude B, Krämer U, Heinrich J, Tiemeier H, Forastiere F, Pershagen G, Brunekreef B, Guxens M. Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe. Epidemiology. 2018 Sep;29(5):618-626. PMID: 29923866
Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: a Meta-analysis of Individual-participant Data
Levie D, Korevaar TIM, Bath SC, Dalmau-Bueno A, Murcia M, Espada M, Dineva M, Ibarluzea JM, Sunyer J, Tiemeier H, Rebagliato M, Rayman MP, Peeters RP, Guxens M. Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: a Meta-analysis of Individual-participant Data. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2967-2979. PMID: 29757392
Prenatal and postnatal exposure to persistent organic pollutants (POPs) and attention-deficit and hyperactivity disorder (ADHD): a pooled analysis of seven European birth cohort studies
Forns J, Stigum H, Høyer BB, Sioen I, Sovcikova E, Nowack N, Lopez-Espinosa MJ, Guxens M, Ibarluzea J, Torrent M, Wittsiepe J, Govarts E, Trnovec T, Chevrier C, Toft G, Vrijheid M, Iszatt N, Eggesbø M. Prenatal and postnatal exposure to persistent organic pollutants (POPs) and attention-deficit and hyperactivity disorder (ADHD): a pooled analysis of seven European birth cohort studies. Int J Epidemiol. 2018 Aug 1;47(4):1082-1097. PMID: 29912347
Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis
Patro Golab B, Santos S, Voerman E, Lawlor DA, Jaddoe VWV, Gaillard R; MOCO Study Group Authors. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. Lancet Child Adolesc Health. 2018 Nov;2(11):812-821. PMID: 30201470
Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach
Maitre L, Robinson O, Martinez D, Toledano MB, Ibarluzea J, Marina LS, Sunyer J, Villanueva CM, Keun HC, Vrijheid M, Coen M. Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach. Environ Sci Technol. 2018 Nov 20;52(22):13469-13480. PMID: 30285427
Maternal cell phone use during pregnancy and child cognition at age 5 years in 3 birth cohorts
Sudan M, Birks LE, Aurrekoetxea JJ, Ferrero A, Gallastegi M, Guxens M, Ha M, Lim H, Olsen J, González-Safont L, Vrijheid M, Kheifets L. Maternal cell phone use during pregnancy and child cognition at age 5 years in 3 birth cohorts. Environ Int. 2018 Nov;120:155-162. PMID: 30096609
Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?
Eeftens M, Struchen B, Birks LE, Cardis E, Estarlich M, Fernandez MF, Gajšek P, Gallastegi M, Huss A, Kheifets L, Meder IK, Olsen J, Torrent M, Trček T, Valič B, Vermeulen R, Vrijheid M, van Wel L, Guxens M, Röösli M. Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?. Environ Int. 2018 Dec;121(Pt 1):216-226. PMID: 30216774
The INMA-INfancia y Medio Ambiente-(Environment and Childhood) project: More than 10 years contributing to environmental and neuropsychological research
Gascon M, Guxens M, Vrijheid M, Torrent M, Ibarluzea J, Fano E, Llop S, Ballester F, Fernández MF, Tardón A, Fernández-Somoano A, Sunyer J. The INMA-INfancia y Medio Ambiente-(Environment and Childhood) project: More than 10 years contributing to environmental and neuropsychological research. Int J Hyg Environ Health. 2017 Jun;220(4):647-658. PMID: 28291591
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