Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease

Goodrich JA, Wang H, Jia Q, Stratakis N, Zhao Y, Maitre L, Bustamante M, Vafeiadi M, Aung M, Andrušaitytė S, Basagana X, Farzan SF, Heude B, Keun H, McConnell R, Yang TC, Siskos AP, Urquiza J, Valvi D, Varo N, Småstuen Haug L, Oftedal BM, Gražulevičienė R, Philippat C, Wright J, Vrijheid M, Chatzi L, Conti DV. Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease. Environ Int. 2024 Aug;190:108930. PMID: 39128376

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Wang S, Casey E, Sordillo J, Aguilar-Lacasaña S, Morales Berstein F, Biedrzycki RJ, Brescianini S, Chen S, Hough A, Isaevska E, Kim WJ, Lecorguillé M, Li SS, Page CM, Park J, Röder S, Salontaji K, Santorelli G, Sun Y, Won S, Zillich E, Zillich L, Annesi-Maesano I, Arshad SH, Bustamante M, Cecil CAM, Elliott HR, Ewart S, Felix JF, Gagliardi L, Håberg SE, Herberth G, Heude B, Holloway JW, Huels A, Karmaus W, Koppelman GH, London SJ, Mumford SL, Nisticò L, Popovic M, Rusconi F, Schisterman EF, Stein DJ, Send T, Tiemeier H, Vonk JM, Vrijheid M, Wiemels JL, Witt SH, Wright J, Yeung EH, Zar HJ, Zenclussen AC, Zhang H, Chavarro JE, Hivert MF. Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium. Sci Adv. 2024 Nov 29;10(48):eadr2084. PMID: 39602535

Machine learning-based health environmental-clinical risk scores in European children

Guimbaud JB, Siskos AP, Sakhi AK, Heude B, Sabidó E, Borràs E, Keun H, Wright J, Julvez J, Urquiza J, Gützkow KB, Chatzi L, Casas M, Bustamante M, Nieuwenhuijsen M, Vrijheid M, López-Vicente M, de Castro Pascual M, Stratakis N, Robinson O, Grazuleviciene R, Slama R, Alemany S, Basagaña X, Plantevit M, Cazabet R, Maitre L. Machine learning-based health environmental-clinical risk scores in European children. Commun Med (Lond). 2024 May 23;4(1):98. PMID: 38783062

Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis

Derakhshan A, Männistö T, Chen L, Osinga JAJ, Ashoor G, Lu X, Bliddal S, Tao FB, Brown SJ, Vaidya B, Hattersley AT, Itoh S, Popova PV, Aminorroaya A, Kishi R, Kianpour M, Vasukova EA, López-Bermejo A, Oken E, Chatzi L, Vafeiadi M, Bramer WM, Bassols J, Lertxundi A, Fernández-Somoano A, Carrasco P, Auvinen J, Huang K, Feldt-Rasmussen U, Grineva EN, Alexander EK, Pearce EN, Chaker L, Walsh JP, Peeters RP, Guxens M, Suvanto E, Nicolaides KH, Korevaar TIM. Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis. J Clin Endocrinol Metab. 2024 Feb 20;109(3):e1290-e1298. PMID: 37878891

Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA)

Oncina-Cánovas A, Vioque J, Riutort-Mayol G, Soler-Blasco R, Irizar A, Barroeta Z, Fernández-Somoano A, Tardón A, Vrijheid M, Guxens M, Carey M, Meharg C, Ralphs K, McCreanor C, Meharg A, Signes-Pastor AJ. Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA). Int J Hyg Environ Health. 2024 Apr;257:114344. PMID: 38430670

Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis

Osinga JAJ, Liu Y, Männistö T, Vafeiadi M, Tao FB, Vaidya B, Vrijkotte TGM, Mosso L, Bassols J, López-Bermejo A, Boucai L, Aminorroaya A, Feldt-Rasmussen U, Hisada A, Yoshinaga J, Broeren MAC, Itoh S, Kishi R, Ashoor G, Chen L, Veltri F, Lu X, Taylor PN, Brown SJ, Chatzi L, Popova PV, Grineva EN, Ghafoor F, Pirzada A, Kianpour M, Oken E, Suvanto E, Hattersley A, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Delgado-Saborit JM, Fernández-Somoano A, Santa-Marina L, Boelaert K, Brenta G, Dhillon-Smith R, Dosiou C, Eaton JL, Guan H, Lee SY, Maraka S, Morris-Wiseman LF, Nguyen CT, Shan Z, Guxens M, Pop VJM, Walsh JP, Nicolaides KH, D’Alton ME, Visser WE, Carty DM, Delles C, Nelson SM, Alexander EK, Chaker L, Palomaki GE, Peeters RP, Bliddal S, Huang K, Poppe KG, Pearce EN, Derakhshan A, Korevaar TIM. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis. Thyroid. 2024 May;34(5):646-658. PMID: 38546971

Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood

Crooijmans KLHA, Iñiguez C, Withworth KW, Estarlich M, Lertxundi A, Fernández-Somoano A, Tardón A, Ibarluzea J, Sunyer J, Guxens M, Binter AC. Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood. Environ Int. 2024 Apr;186:108604. PMID: 38564945

Evaluating the association between placenta DNA methylation and cognitive functions in the offspring

Diez-Ahijado L, Cilleros-Portet A, Fernández-Jimenez N, Fernández MF, Guxens M, Julvez J, Llop S, Lopez-Espinosa MJ, Subiza-Pérez M, Lozano M, Ibarluzea J, Sunyer J, Bustamante M, Cosin-Tomas M. Evaluating the association between placenta DNA methylation and cognitive functions in the offspring. Transl Psychiatry. 2024 Sep 20;14(1):383. PMID: 39304652

Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium

Yeung E, Biedrzycki RJ, Gómez Herrera LC, Issarapu P, Dou J, Marques IF, Mansuri SR, Page CM, Harbs J, Khodasevich D, Poisel E, Niu Z, Allard C, Casey E, Berstein FM, Mancano G, Elliott HR, Richmond R, He Y, Ronkainen J, Sebert S, Bell EM, Sharp G, Mumford SL, Schisterman EF, Chandak GR, Fall CHD, Sahariah SA, Silver MJ, Prentice AM, Bouchard L, Domellof M, West C, Holland N, Cardenas A, Eskenazi B, Zillich L, Witt SH, Send T, Breton C, Bakulski KM, Fallin MD, Schmidt RJ, Stein DJ, Zar HJ, Jaddoe VWV, Wright J, Grazuleviciene R, Gutzkow KB, Sunyer J, Huels A, Vrijheid M, Harlid S, London S, Hivert MF, Felix J, Bustamante M, Guan W. Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium. Aging Cell. 2024 Aug;23(8):e14194. PMID: 38808605

Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

Cilleros-Portet A, Lesseur C, Marí S, Cosin-Tomas M, Lozano M, Irizar A, Burt A, García-Santisteban I, Garrido-Martín D, Escaramís G, Hernangomez-Laderas A, Soler-Blasco R, Breeze CE, Gonzalez-Garcia BP, Santa-Marina L, Chen J, Llop S, Fernández MF, Vrijheid M, Ibarluzea J, Guxens M, Marsit C, Bustamante M, Bilbao JR, Fernandez-Jimenez N. Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. Nat Commun. 2025 Mar 14;16(1):2431. PMID: 40087310

Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, Thijs C. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. PMID: 39147399

Common genetic variants associated with urinary phthalate levels in children: A genome-wide study

Bustamante M, Balagué-Dobón L, Buko Z, Sakhi AK, Casas M, Maitre L, Andrusaityte S, Grazuleviciene R, Gützkow KB, Brantsæter AL, Heude B, Philippat C, Chatzi L, Vafeiadi M, Yang TC, Wright J, Hough A, Ruiz-Arenas C, Nurtdinov RN, Escaramís G, González JR, Thomsen C, Vrijheid M. Common genetic variants associated with urinary phthalate levels in children: A genome-wide study. Environ Int. 2024 Aug;190:108845. PMID: 38945087