Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

299 Results

Neurodevelopment -
Stress -


Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying

Babarro I, Ibarluzea J, Theodorsson E, Fano E, Lebeña A, Guxens M, Sunyer J, Andiarena A. Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying. Child Neuropsychol. 2023 Jul;29(5):742-759. PMID: 36036166


Metals -
Nutrition -


Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain

Notario-Barandiaran L, Irizar A, Begoña-Zubero M, Soler-Blasco R, Riutort-Mayol G, Fernández-Somoano A, Tardón A, Casas M, Vrijheid M, Meharg A, Carey M, Meharg C, Ralphs K, McCreanor C, Grimalt JO, Vioque J, Signes-Pastor AJ. Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain. Environ Res. 2023 Sep 15;233:116508. PMID: 37392824


Hormonal disturbances -
Reproductive health -


Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women

Dineva M, Rayman MP, Levie D, Hunziker S, Guxens M, Peeters RP, Murcia M, Rebagliato M, Irizar A, Jimeno-Romero A, Sunyer J, Korevaar TIM, Bath SC. Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women. Eur J Nutr. 2023 Aug;62(5):2139-2154. PMID: 36973522


Genetics -
Neurodevelopment -


Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

Cilleros-Portet A, Lesseur C, Marí S, Cosin-Tomas M, Lozano M, Irizar A, Burt A, García-Santisteban I, Martín DG, Escaramís G, Hernangomez-Laderas A, Soler-Blasco R, Breeze CE, Gonzalez-Garcia BP, Santa-Marina L, Chen J, Llop S, Fernández MF, Vrijhed M, Ibarluzea J, Guxens M, Marsit C, Bustamante M, Bilbao JR, Fernandez-Jimenez N. Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. medRxiv [Preprint]. 2023 Mar 8:2023.03.07.23286905. PMID: 36945560


Epigenetics -
Sleep problems -


Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain

Petermann-Rocha F, Valera-Gran D, Fernández-Pires P, Martens DS, Júlvez J, Rodríguez-Dehli C, Andiarena A, Lozano M, Fernández-Somoano A, Lertxundi A, Llop S, Guxens M, Nawrot TS, Navarrete-Muñoz EM. Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain. Pediatr Res. 2023 Apr;93(5):1419-1424. PMID: 35974160


No persistent organic compounds -
Sexual development -


Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort

Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C. Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort. Environ Pollut. 2023 Jan 1;316(Pt 2):120571. PMID: 36356884


Built environment and Greeness -
Intrauterine growth -


Associations of residential greenspace exposure and fetal growth across four areas in Spain

Torres Toda M, Estarlich M, Ballester F, De Castro M, Fernández-Somoano A, Ibarluzea J, Iñiguez C, Lertxundi A, Subiza-Perez M, Sunyer J, Tardón A, Foraster M, Dadvand P. Associations of residential greenspace exposure and fetal growth across four areas in Spain. Health Place. 2022 Nov;78:102912. PMID: 36182749


Metals -
Neurodevelopment -


Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study

Díaz-López A, Canals-Sans J, Julvez J, Fernandez-Barrés S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V. Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study. Sci Rep. 2022 Dec 1;12(1):20762. PMID: 36456588


Metals -
Nutrition -
Respiratory health and atopy -


Arsenic exposure and respiratory outcomes during childhood in the INMA study

Signes-Pastor AJ, Díaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, García-Villarino M, Fernández-Somoano A, Julvez J, Carrasco P, Lertxundi A, Santa Marina L, Casas M, Meharg AA, Karagas MR, Vioque-Lopez J. Arsenic exposure and respiratory outcomes during childhood in the INMA study. PLoS One. 2022 Sep 9;17(9):e0274215. PMID: 36083997


Neurodevelopment -
Nutrition -


Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7-9 Years of Age in the INMA Cohort Study

Compañ-Gabucio LM, Torres-Collado L, Garcia-de la Hera M, Fernández-Somoano A, Tardón A, Julvez J, Sunyer J, Rebagliato M, Murcia M, Ibarluzea J, Santa-Marina L, Vioque J. Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7-9 Years of Age in the INMA Cohort Study. Int J Environ Res Public Health. 2022 Sep 25;19(19):12123. PMID: 36231425


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