Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

330 Results

Postnatal growth and Obesity -
Postnatal growth and Obesity -
Reproductive health -
Reproductive health -


Associations of Maternal Educational Level, Proximity to Greenspace During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

Cadman T, Elhakeem A, Vinther JL, Avraam D, Carrasco P, Calas L, Cardo M, Charles MA, Corpeleijn E, Crozier S, de Castro M, Estarlich M, Fernandes A, Fossatti S, Gruszfeld D, Gurlich K, Grote V, Haakma S, Harris JR, Heude B, Huang RC, Ibarluzea J, Inskip H, Jaddoe V, Koletzko B, Luque V, Manios Y, Moirano G, Moschonis G, Nader J, Nieuwenhuijsen M, Andersen AN, McEachen R, de Moira AP, Popovic M, Roumeliotaki T, Salika T, Marina LS, Santos S, Serbert S, Tzorovili E, Vafeiadi M, Verduci E, Vrijheid M, Vrijkotte TGM, Welten M, Wright J, Yang TC, Zugna D, Lawlor D. Associations of Maternal Educational Level, Proximity to Greenspace During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts. Am J Epidemiol. 2024 May 7;193(5):753-763. PMID: 37856700


Metals -
Metals -
Neurodevelopment -
Neurodevelopment -


Association of maternal prenatal urinary fluoride levels with ADHD symptoms in childhood

Ibarluzea J, Subiza-Pérez M, Arregi A, Molinuevo A, Arranz-Freijo E, Sánchez-de Miguel M, Jiménez A, Andiarena A, Santa-Marina L, Lertxundi A. Association of maternal prenatal urinary fluoride levels with ADHD symptoms in childhood. Environ Res. 2023 Oct 15;235:116705. PMID: 37479215


Exposome -
Exposome -
Vitamin D -
Vitamin D -


Sociodemographic, lifestyle, and environmental determinants of vitamin D levels in pregnant women in Spain

Llopis M, Ventura PS, Brachowicz N, Sangüesa J, Murcia M, Lopez-Espinosa MJ, García-Baquero G, Lertxundi A, Vrijheid M, Casas M, Petrone P. Sociodemographic, lifestyle, and environmental determinants of vitamin D levels in pregnant women in Spain. Environ Int. 2023 Dec;182:108293. PMID: 37984291


Neurodevelopment -
Neurodevelopment -
Sleep problems -
Sleep problems -


Sleep problems at ages 8-9 and ADHD symptoms at ages 10-11: evidence in three cohorts from INMA study

González-Safont L, Rebagliato M, Arregi A, Carrasco P, Guxens M, Vegas O, Julvez J, Estarlich M. Sleep problems at ages 8-9 and ADHD symptoms at ages 10-11: evidence in three cohorts from INMA study. Eur J Pediatr. 2023 Nov;182(11):5211-5222. PMID: 37721582


No persistent organic compounds -
Persistent organic compounds -
Postnatal growth and Obesity -
No persistent organic compounds -
Persistent organic compounds -
Postnatal growth and Obesity -


Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study

Montazeri P, Güil-Oumrait N, Marquez S, Cirugeda L, Beneito A, Guxens M, Lertxundi A, Lopez-Espinosa MJ, Santa-Marina L, Sunyer J, Casas M, Vrijheid M. Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study. Environ Health Perspect. 2023 Oct;131(10):107006. PMID: 37850789


Epigenetics -
Epigenetics -
Nutrition -
Nutrition -


Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study

Petermann-Rocha F, Valera-Gran D, Prieto-Botella D, Martens DS, Gonzalez-Palacios S, Riaño-Galán I, Murcia M, Irizar A, Julvez J, Santa-Marina L, Tardón A, Sunyer J, Vioque J, Nawrot T, Navarrete-Muñoz EM. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study. Nutrients. 2023 Oct 9;15(19):4303. PMID: 37836587


Postnatal growth and Obesity -
Postnatal growth and Obesity -


Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index

Descarpentrie A, Calas L, Cornet M, Heude B, Charles MA, Avraam D, Brescianini S, Cadman T, Elhakeem A, Fernández-Barrés S, Harris JR, Inskip H, Julvez J, Llop S, Margetaki K, Maritano S, Nader JLT, Roumeliotaki T, Salika T, Subiza-Pérez M, Vafeiadi M, Vrijheid M, Wright J, Yang T, Dargent-Molina P, Lioret S. Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index. Pediatr Obes. 2023 Dec;18(12):e13079. PMID: 37795656


Genetics -
Genetics -
Metals -
Metals -
Neurodevelopment -
Neurodevelopment -


Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children

Soler-Blasco R, Llop S, Riutort-Mayol G, Lozano M, Vallejo-Ortega J, Murcia M, Ballester F, Irizar A, Andiarena A, Fernandez-Jimenez N, Braeuer S, Harari F. Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children. Environ Sci Technol. 2023 Oct 17;57(41):15366-15378. PMID: 37787746


Exposome -
Exposome -
Respiratory health and atopy -
Respiratory health and atopy -


A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles

Kiewiet MBG, Lupinek C, Vrtala S, Wieser S, Baar A, Kiss R, Kull I, Melén E, Wickman M, Porta D, Gori D, Gehring U, Aalberse R, Sunyer J, Standl M, Heinrich J, Waiblinger D, Wright J, Antó JM, Bousquet J, van Hage M, Valenta R. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles. Allergy. 2023 Jul;78(7):2007-2018. PMID: 36815272


Respiratory health and atopy -
Respiratory health and atopy -


Creatine Kinase Is Decreased in Childhood Asthma

Guerra S, Ledford JG, Melén E, Lavi I, Carsin AE, Stern DA, Zhai J, Vidal M, Bustamante M, Addison KJ, Vallecillo RG, Billheimer D, Koppelman GH, Garcia-Aymerich J, Lemonnier N, Fitó M, Dobaño C, Kebede Merid S, Kull I, McEachan RRC, Wright J, Chatzi L, Kogevinas M, Porta D, Narduzzi S, Ballester F, Esplugues A, Zabaleta C, Irizar A, Sunyer J, Halonen M, Bousquet J, Martinez FD, Anto JM. Creatine Kinase Is Decreased in Childhood Asthma. Am J Respir Crit Care Med. 2023 Mar 1;207(5):544-552. PMID: 35876143


3 / 33