Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

316 Results

Epigenetics -
Physical activity - sedentary lifestyle -


Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study

Prieto-Botella D, Martens DS, Valera-Gran D, Subiza-Pérez M, Tardón A, Lozano M, Casas M, Bustamante M, Jimeno-Romero A, Fernández-Somoano A, Llop S, Vrijheid M, Nawrot TS, Navarrete-Muñoz EM. Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study. Int J Environ Res Public Health. 2023 Mar 14;20(6):5134. PMID: 36982042


No persistent organic compounds -
Respiratory health and atopy -


Gestational phthalate exposure and lung function during childhood: A prospective population-based study

Bosch de Basea M, Carsin AE, Abellan A, Cobo I, Lertxundi A, Marin N, Soler-Blasco R, Ibarluzea J, Vrijheid M, Sunyer J, Casas M, Garcia-Aymerich J. Gestational phthalate exposure and lung function during childhood: A prospective population-based study. Environ Pollut. 2022 Nov 1;312:119833. PMID: 35931390


Postnatal growth and Obesity -
Vitamin D -


Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys

Sanguesa J, Marquez S, Bustamante M, Sunyer J, Iniguez C, Vioque J, Rodriguez LS, Jimeno-Romero A, Torrent M, Casas M, Vrijheid M. Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys. Nutrients. 2023 Apr 23;15(9):2033. PMID: 37432159


Postnatal growth and Obesity -
Reproductive health -


Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies

Vinther JL, Cadman T, Avraam D, Ekstrøm CT, Sørensen TIA, Elhakeem A, Santos AC, Pinot de Moira A, Heude B, Iñiguez C, Pizzi C, Simons E, Voerman E, Corpeleijn E, Zariouh F, Santorelli G, Inskip HM, Barros H, Carson J, Harris JR, Nader JL, Ronkainen J, Strandberg-Larsen K, Santa-Marina L, Calas L, Cederkvist L, Popovic M, Charles MA, Welten M, Vrijheid M, Azad M, Subbarao P, Burton P, Mandhane PJ, Huang RC, Wilson RC, Haakma S, Fernández-Barrés S, Turvey S, Santos S, Tough SC, Sebert S, Moraes TJ, Salika T, Jaddoe VWV, Lawlor DA, Nybo Andersen AM. Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies. PLoS Med. 2023 Jan 26;20(1):e1004036. PMID: 36701266
Correction: Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies. PLoS Med. 2023 Apr 18;20(4):e1004232. PMID: 37071835


Genetics -
Metals -
Neurodevelopment -


Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort

Soler-Blasco R, Harari F, Riutort-Mayol G, Murcia M, Lozano M, Irizar A, Marina LS, Zubero MB, Fernández-Jimenez N, Braeuer S, Ballester F, Llop S. Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort. Sci Total Environ. 2023 Nov 20:900:165740. PMID: 37495132


Respiratory health and atopy -
Vitamin D -


Prenatal and child vitamin D levels and allergy and asthma in childhood

Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, Garcia-Aymerich J, Guxens M, Irizar A, Júlvez J, Luque-García L, Rodríguez-Dehli AC, Tardón A, Torrent M, Vioque J, Vrijheid M, Casas M. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023 May;93(6):1745-1751. PMID: 36057646


Neurodevelopment -
Stress -


Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying

Babarro I, Ibarluzea J, Theodorsson E, Fano E, Lebeña A, Guxens M, Sunyer J, Andiarena A. Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying. Child Neuropsychol. 2023 Jul;29(5):742-759. PMID: 36036166


Metals -
Nutrition -


Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain

Notario-Barandiaran L, Irizar A, Begoña-Zubero M, Soler-Blasco R, Riutort-Mayol G, Fernández-Somoano A, Tardón A, Casas M, Vrijheid M, Meharg A, Carey M, Meharg C, Ralphs K, McCreanor C, Grimalt JO, Vioque J, Signes-Pastor AJ. Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain. Environ Res. 2023 Sep 15;233:116508. PMID: 37392824


Hormonal disturbances -
Reproductive health -


Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women

Dineva M, Rayman MP, Levie D, Hunziker S, Guxens M, Peeters RP, Murcia M, Rebagliato M, Irizar A, Jimeno-Romero A, Sunyer J, Korevaar TIM, Bath SC. Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women. Eur J Nutr. 2023 Aug;62(5):2139-2154. PMID: 36973522


Genetics -
Neurodevelopment -


Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

Cilleros-Portet A, Lesseur C, Marí S, Cosin-Tomas M, Lozano M, Irizar A, Burt A, García-Santisteban I, Martín DG, Escaramís G, Hernangomez-Laderas A, Soler-Blasco R, Breeze CE, Gonzalez-Garcia BP, Santa-Marina L, Chen J, Llop S, Fernández MF, Vrijhed M, Ibarluzea J, Guxens M, Marsit C, Bustamante M, Bilbao JR, Fernandez-Jimenez N. Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. medRxiv [Preprint]. 2023 Mar 8:2023.03.07.23286905. PMID: 36945560


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