Gipuzkoa

In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.

The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.

Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.

  • Funders of INMA-Gipuzkoa cohort:

This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).

  • Collaborating Entities:

Buscador

269 Results

Metals -
Neurodevelopment -


Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children

Ibarluzea J, Gallastegi M, Santa-Marina L, Jiménez Zabala A, Arranz E, Molinuevo A, Lopez-Espinosa MJ, Ballester F, Villanueva CM, Riano I, Sunyer J, Tardon A, Lertxundi A. Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children. Environ Res. 2022 May 1;207:112181. PMID: 34627799


Electromagnetics field -
Sleep problems -


Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents

Cabré-Riera A, van Wel L, Liorni I, Koopman-Verhoeff ME, Imaz L, Ibarluzea J, Huss A, Wiart J, Vermeulen R, Joseph W, Capstick M, Vrijheid M, Cardis E, Röösli M, Eeftens M, Thielens A, Tiemeier H, Guxens M. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents. Environ Res. 2022 Mar;204(Pt C):112291. PMID: 34757029


Metals -
Nutrition -
Tobacco -


Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

Lozano M, Murcia M, Soler-Blasco R, Casas M, Zubero B, Riutort-Mayol G, Gil F, Olmedo P, Grimalt JO, Amorós R, Lertxundi A, Vrijheid M, Ballester F, Llop S. Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors. Chemosphere. 2022 Jan;286(Pt 2):131809. PMID: 34388877


Exposome -
Neurodevelopment -


Urban environment and cognitive and motor function in children from four European birth cohorts

Binter AC, Bernard JY, Mon-Williams M, Andiarena A, González-Safont L, Vafeiadi M, Lepeule J, Soler-Blasco R, Alonso L, Kampouri M, Mceachan R, Santa- Marina L, Wright J, Chatzi L, Sunyer J, Philippat C, Nieuwenhuijsen M, Vrijheid M, Guxens M. Urban environment and cognitive and motor function in children from four European birth cohorts. Environ Int. 2022 Jan;158:106933. PMID: 34662798


Breastfeeding -
No persistent organic compounds -


Concentrations of bisphenols, parabens, and benzophenones in human breast milk: A systematic review and meta-analysis

Iribarne-Durán LM, Peinado FM, Freire C, Castillero-Rosales I, Artacho-Cordón F, Olea N. Concentrations of bisphenols, parabens, and benzophenones in human breast milk: A systematic review and meta-analysis. Sci Total. 2022 Feb 1;806(Pt 1):150437. PMID: 34583069


Respiratory health and atopy -


Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

Wang G, Hallberg J, Charalampopoulos D, Sanahuja MC, Breyer-Kohansal R, Langhammer A, Granell R, Vonk JM, Mian A, Olvera N, Laustsen LM, Rönmark E, Abellan A, Agusti A, Arshad SH, Bergström A, Boezen HM, Breyer MK, Burghuber O, Bolund AC, Custovic A, Devereux G, Donaldson GC, Duijts L, Esplugues A, Faner R, Ballester F, Garcia-Aymerich J, Gehring U, Haider S, Hartl S, Backman H, Holloway JW, Koppelman GH, Lertxundi A, Holmen TL, Lowe L, Mensink-Bout SM, Murray CS, Roberts G, Hedman L, Schlünssen V, Sigsgaard T, Simpson A, Sunyer J, Torrent M, Turner S, Van den Berge M, Vermeulen RCH, Vikjord SAA, Wedzicha JA, Maitland van der Zee AH, Melén E. Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study. ERJ Open Res. 2021 Dec 6;7(4):00457-2021. PMID: 34881328


Postnatal growth and Obesity -


Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Maria LC Iurilli, James E Bennett, Rodrigo M Carrillo-Larco, ……, Ibarluzea J, Santa- Marina. LNCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife. 2021 Mar 9;10:e60060. PMID: 33685583


Air pollution -
Entorno urbano y Verdor -
Metabolomics -


Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort

Rammah A, Whitworth KW, Amos CI, Estarlich M, Guxens M, Ibarluzea J, Iñiguez C, Subiza-Pérez M, Vrijheid M, Symanski E. Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort. Int J Environ Res Public Health. 2021 Sep 4;18(17):9354.PMID: 34501944


Epigenetics -
Reproductive health -
Tobacco -


Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Everson TM, Vives-Usano M, Seyve E, Cardenas A, Lacasaña M, Craig JM, Lesseur C, Baker ER, Fernandez-Jimenez N, Heude B, Perron P, Gónzalez-Alzaga B, Halliday J, Deyssenroth MA, Karagas MR, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke YJ, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández MF, Tost J, Gómez-Martín A, London SJ, Sunyer J, Marsit CJ, Lepeule J, Hivert MF, Bustamante M. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. Nat Commun. 2021 Aug 24;12(1):5095. PMID: 34429407


No persistent organic compounds -
Postnatal growth and Obesity -
Sexual development -


Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence

Castiello F, Freire C. Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence. Eur J Endocrinol. 2021 May 4;184(6):733-749. PMID: 33769962


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